Multiple microRNAs regulate human FOXP2 gene expression by targeting sequences in its 3′ untranslated region

Molecular Brain

Volumn 7, Issue 1, 2014, Pages

  Fu, Lijuan ^a   Shi, Zhimin ^a   Luo, Guanzheng ^b   Tu, Weihong ^a   Wang, Xiujie ^b   Fang, Zhide ^c   Li, Xiaoching ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

3 UTR; Cerebellum; FOXP2; miRNAs; Post transcriptional regulation; Speech and language

Indexed keywords

MICRORNA; MICRORNA 129 5P; MICRORNA 9; MICRORNA LET 7A; TRANSCRIPTION FACTOR FOXP2; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; FORKHEAD TRANSCRIPTION FACTOR; FOXP2 PROTEIN, HUMAN; MESSENGER RNA;

3' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CEREBELLUM; CONTROLLED STUDY; FETUS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENE TARGETING; HUMAN; IN VITRO STUDY; RNA BINDING; SEQUENCE ANALYSIS; DOWN REGULATION; EMBRYOLOGY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; BINDING SITES; CEREBELLUM; DOWN-REGULATION; FETUS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICRORNAS; RNA, MESSENGER;

EID: 84908096053     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/s13041-014-0071-0     Document Type: Article

References (24)

1. A forkhead-domain gene is mutated in a severe speech and language disorder. CS Lai, SE Fisher, JA Hurst, F Vargha-Khadem, AP Monaco, Nature 2001 413 6855 519 523 10.1038/35097076 11586359
2. Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia. L Feuk, A Kalervo, M Lipsanen-Nyman, J Skaug, K Nakabayashi, B Finucane, D Hartung, M Innes, B Kerem, MJ Nowaczyk, J Rivlin, W Roberts, L Senman, A Summers, P Szatmari, V Wong, JB Vincent, S Zeesman, LR Osborne, JO Cardy, J Kere, SW Scherer, K Hannula-Jouppi, Am J Hum Genet 2006 79 5 965 972 10.1086/508902 17033973
3. Deletion of 7q31.1 supports involvement of FOXP2 in language impairment: clinical report and review. PA Lennon, ML Cooper, DA Peiffer, KL Gunderson, A Patel, S Peters, SW Cheung, CA Bacino CA, Am J Med Genet A 2007 143A 8 791 798 10.1002/ajmg.a.31632 17330859
4. Speech, prosody, and voice characteristics of a mother and daughter with a 7;13 translocation affecting FOXP2. LD Shriberg, KJ Ballard, JB Tomblin, JR Duffy, KH Odell, CA Williams, J Speech Lang Hear Res 2006 49 3 500 525 10.1044/1092-4388(2006/038) 16787893
5. Speech and language impairment and oromotor dyspraxia due to deletion of 7q31 that involves FOXP2. S Zeesman, MJ Nowaczyk, I Teshima, W Roberts, JO Cardy, J Brian, L Senman, L Feuk, LR Osborne, SW Scherer, Am J Med Genet A 2006 140 5 509 514 10.1002/ajmg.a.31110 16470794
6. Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. KD MacDermot, E Bonora, N Sykes, AM Coupe, CS Lai, SC Vernes, F Vargha-Khadem, F McKenzie, RL Smith, AP Monaco, SE Fisher, Am J Hum Genet 2005 76 6 1074 1080 10.1086/430841 15877281
7. Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. W Shu, H Yang, L Zhang, MM Lu, EE Morrisey, J Biol Chem 2001 276 29 27488 27497 10.1074/jbc.M100636200 11358962
8. Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. E Spiteri, G Konopka, G Coppola, J Bomar, M Oldham, J Ou, SC Vernes, SE Fisher, B Ren, DH Geschwind, Am J Hum Genet 2007 81 6 1144 1157 10.1086/522237 17999357
9. Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. SC Vernes, PL Oliver, E Spiteri, HE Lockstone, R Puliyadi, JM Taylor, J Ho, C Mombereau, A Brewer, E Lowy, J Nicod, M Groszer, D Baban, N Sahgal, JB Cazier, J Ragoussis, KE Davies, DH Geschwind, SE Fisher, PLoS Genet 2011 7 7 1002145 10.1371/journal.pgen.1002145 21765815
10. High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders. SC Vernes, E Spiteri, J Nicod, M Groszer, JM Taylor, KE Davies, DH Geschwind, SE Fisher, Am J Hum Genet 2007 81 6 1232 1250 10.1086/522238 17999362
11. Human-specific transcriptional regulation of CNS development genes by FOXP2. G Konopka, JM Bomar, K Winden, G Coppola, ZO Jonsson, F Gao, S Peng, TM Preuss, JA Wohlschlegel, DH Geschwind, Nature 2009 462 7270 213 217 10.1038/nature08549 19907493
12. FOXP2 as a molecular window into speech and language. SE Fisher, C Scharff, Trends Genet 2009 25 4 166 177 10.1016/j.tig.2009.03.002 19304338
13. Decoding the genetics of speech and language. SA Graham, SE Fisher, Curr Opin Neurobiol 2013 23 1 43 51 10.1016/j.conb.2012.11.006 23228431
14. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. RC Lee, RL Feinbaum, V Ambros, Cell 1993 75 5 843 854 10.1016/0092-8674(93)90529-Y 8252621
15. MicroRNAs: target recognition and regulatory functions. DP Bartel, Cell 2009 136 2 215 233 10.1016/j.cell.2009.01.002 19167326
16. Most mammalian mRNAs are conserved targets of microRNAs. RC Friedman, KK Farh, CB Burge, DP Bartel, Genome Res 2009 19 1 92 105 10.1101/gr.082701.108 18955434
17. A mammalian microRNA expression atlas based on small RNA library sequencing. P Landgraf, M Rusu, R Sheridan, A Sewer, N Iovino, A Aravin, S Pfeffer, A Rice, AO Kamphorst, M Landthaler, C Lin, ND Socci, L Hermida, V Fulci, S Chiaretti, R Foa, J Schliwka, U Fuchs, A Novosel, RU Muller, B Schermer, U Bissels, J Inman, Q Phan, M Chien, DB Weir, R Choksi, G De Vita, D Frezzetti, HI Trompeter, et al. Cell 2007 129 7 1401 1414 10.1016/j.cell.2007.04.040 17604727
18. miRNA in situ hybridization in formaldehyde and EDC-fixed tissues. JT Pena, C Sohn-Lee, SH Rouhanifard, J Ludwig, M Hafner, A Mihailovic, C Lim, D Holoch, P Berninger, M Zavolan, T Tuschl, Nat Methods 2009 6 2 139 141 10.1038/nmeth.1294 19137005
19. FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. CS Lai, D Gerrelli, AP Monaco, SE Fisher, AJ Copp, Brain 2003 126 Pt 11 2455 2462 10.1093/brain/awg247 12876151
20. Functional genetic analysis of mutations implicated in a human speech and language disorder. SC Vernes, J Nicod, FM Elahi, JA Coventry, N Kenny, AM Coupe, LE Bird, KE Davies, SE Fisher, Hum Mol Genet 2006 15 21 3154 3167 10.1093/hmg/ddl392 16984964
21. Convergent repression of Foxp2 3′UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons. YM Clovis, W Enard, F Marinaro, WB Huttner, D De Pietri Tonelli, Development 2012 139 18 3332 3342 10.1242/dev.078063 22874921
22. miR-9 and miR-140-5p target FoxP2 and are regulated as a function of the social context of singing behavior in zebra finches. Z Shi, G Luo, L Fu, Z Fang, X Wang, X Li, J Neurosci 2013 33 42 16510 16521 10.1523/JNEUROSCI.0838-13.2013 24133256
23. MRI analysis of an inherited speech and language disorder: structural brain abnormalities. KE Watkins, F Vargha-Khadem, J Ashburner, RE Passingham, A Connelly, KJ Friston, RS Frackowiak, M Mishkin, DG Gadian, Brain 2002 125 Pt 3 465 478 10.1093/brain/awf057 11872605
24. Heterogeneous dysregulation of microRNAs across the autism spectrum. K Abu-Elneel, T Liu, FS Gazzaniga, Y Nishimura, DP Wall, DH Geschwind, K Lao, KS Kosik, Neurogenetics 2008 9 3 153 161 10.1007/s10048-008-0133-5 18563458