Thyroid hormone upregulates zinc-α2-glycoprotein production in the liver but not in adipose tissue

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Simó, Rafael ^a   Hernández, Cristina ^a   Sáez López, Cristina ^a   Soldevila, Berta ^b   Puig Domingo, Manel ^b   Selva, David M ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 GLYCOPROTEIN; CARBIMAZOLE; MESSENGER RNA; PROPYLTHIOURACIL; THYROID HORMONE; UNCLASSIFIED DRUG; ZINC ALPHA2 GLYCOPROTEIN;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; EUTHYROIDISM; FEMALE; GENE; GLYCOPROTEIN SYNTHESIS; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; HYPERTHYROIDISM; IN VITRO STUDY; IN VIVO STUDY; LIVER; LUCIFERASE ASSAY; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; UPREGULATION; ZAG GENE;

ADIPOSE TISSUE; ANIMALS; BASE SEQUENCE; BODY WEIGHT; FEMALE; HEP G2 CELLS; HUMANS; HYPERTHYROIDISM; LIPOLYSIS; LIVER; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; SEMINAL PLASMA PROTEINS; THYROID FUNCTION TESTS; TRIIODOTHYRONINE; UP-REGULATION;

EID: 84908082044     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085753     Document Type: Article

References (29)

1. Sanchez LM, Chirino AJ, Bjorkman P (1999) Crystal structure of human ZAG, a fat depleting factor related to MHC molecules. Science 283: 1914-1919.
2. 2-glycoprotein in obesity. Its relationship with adipokine and lipolytic gene markers in subcutaneous and visceral fat. J Clin Endocrinol Metab 94: 5062-5069.
3. Gong FY, Zhang SJ, Deng JY, Zhu HJ, Pan H, et al. (2009) Zinc-alpha2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue. Int J Obes (London) 33: 1023-30.
4. Rolli V, Radosavljevic M, Astier V, Macquin C, Castan-Laurell I, et al. (2007) Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice. FEBS Lett 581: 394-400. (Pubitemid 46157227)
5. 2-glycoprotein in the rat. Int J Obes (Lond) 35: 658-65.
6. Russell ST, Zimmerman TP, Domin BA, Tisdale MJ (2004) Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein. Biochim Biophys Acta 1636: 59-68. (Pubitemid 38231005)
7. Selva DM, Lecube A, Hernandez C, Baena JA, Fort JM, et al. (2009) Lower zinc-α2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance. J Clin Endocrinol Metab 94: 4499-4507.
8. Yeung DC, Lam KS, Wang Y, Tso AW, Xu AM (2009) Serum zinc-&alpha2- glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjects. J Clin Endocrinol Metab 94: 2531-2536.
9. Bing C, Bao Y, Jenkins J, Sanders P, Manieri M, et al. (2004) Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is upregulated in mice with cancer cachexia. Proc Natl Acad Sci 101: 2500-2505. (Pubitemid 38269340)
10. Hirai K, Hussey HJ, Barber MD, Price SA, Tisdale MJ (1998) Biological evaluation of a lipid-mobilizing factor isolated from the urine of cancer patients. Cancer Res 58: 2359-2365. (Pubitemid 28252695)
11. Todorov PT, McDevitt TM, Meyer DJ, Ueyama H, Ohkubo I, et al. (1998) Purification and characterization of a tumor lipid-mobilizing factor. Cancer Res 58: 2353-2358. (Pubitemid 28252694)
12. 2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SHBGS) adipocytes. FEBS Lett 579: 41-47.
13. Gao D, Trayhurn P, Bing C (2010) Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes. Mol Cell Endocrinol 325: 135-42.
14. Flik G (2009) ZigZAGging through fat stores. J Clin Endocrinol Metab 94: 4668-70.
15. Selva DM, Hogeveen KN, Innis S, Hammond GL (2007) Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest. 117(12):3979-87. (Pubitemid 350224107)
16. Chen CY, Chi LM, Chi HC, Tsai MM, Tsai CY, et al. (2012) Stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics study of a thyroid hormone-regulated secretome in human hepatoma cells. Mol Cell Proteomics. 11(4):M111.011270.
17. Bing C, Russell S, Becket E, Pope M, Tisdale MJ, et al. (2006) Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice. Br J Cancer 95: 1028-1037. (Pubitemid 44606829)
18. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91. (Pubitemid 23036092)
19. Russell ST, Tisdale MJ (2005) The role of glucocorticoids in the induction of zinc-α2-glycoprotein expression in adipose tissue in cancer cachexia. Br J Cancer 92: 876-881. (Pubitemid 40462633)
20. Mracek T, Gao D, Tzanavari T, Bao Y, Xiao X, et al. (2010) Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-alpha in adipocytes. J Endocrinol 204: 165-72.
21. Russell ST, Tisdale MJ (2005) Effect of eicosapentaenoic acid (EPA) on expression of a lipid mobilizing factor in adipose tissue in cancer cachexia. Prostaglandins Leukot Essent Fatty Acids 72: 409-14. (Pubitemid 40775722)
22. Moreno-Navarrete JM, Touskova V, Sabater M, Mraz M, Drapalova J, et al. (2013) Liver, but not adipose tissue PEDF gene expression is associated with insulin resistance. Int J Obes (Lond) doi: 10.1038/ijo.2012.223, 2013. [Epub ahead of print].
23. Viguerie N, Millet L, Avizou S, Vidal H, Larrouy D, et al. (2002) Regulation of human adipocyte gene expression by thyroid hormone. J Clin Endocrinol Metab 87: 630-4. (Pubitemid 34158229)
24. Brent GA (2012) Mechanisms of thyroid hormone action. J Clin Invest 122: 3035-43.
25. Bianco AC, Kim BW (2006) Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest 116: 2571-9. (Pubitemid 44511617)
26. Mracek T, Stephens NA, Gao D, Bao Y, Ross JA, et al. (2011) Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients. Br J Cancer 104: 441-7.
27. Philipp A, Kralisch S, Bachmann A, Lossner U, Kratzsch J, et al. (2011) Serum levels of the adipokine zinc-α2-glycoprotein are increased in chronic hemodialysis. Metabolism 60: 669-72.
28. Grasselli E, Voci A, Canesi L, De Matteis R, Goglia F, et al. (2011) Direct effects of iodothyronines on excess fat storage in rat hepatocytes. J Hepatol 54: 1230-6.
29. Ittermann T, Haring R, Wallaschofski H, Baumeister SE, Nauck M, et al. (2012) Inverse association between serum free thyroxine levels and hepatic steatosis: results from the Study of Health in Pomerania. Thyroid 22: 568-74.