Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing müller glial proliferation to generate committed progenitor cells

Journal of Neuroscience

Volumn 34, Issue 43, 2014, Pages 14403-14419

  Conner, Clay ^a   Ackerman, Kristin M ^a   Lahne, Manuela ^a   Hobgood, Joshua S ^a   Hyde, David R ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Ascl1; M ller glia; Notch signaling; Quiescence; Retinal regeneration; Stat3

Indexed keywords

ACHAETE SCUTE COMPLEX LIKE 1A; GAMMA SECRETASE; JANUS KINASE 1; MORPHOLINO OLIGONUCLEOTIDE; NOTCH RECEPTOR; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RETRIEVAL; ARTICLE; BRDU ASSAY; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; IN SITU HYBRIDIZATION; INTRACELLULAR SIGNALING; MALE; MOLECULAR CLONING; MOUSE; MUELLER CELL; NEURAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINA NERVE CELL; RETINA REGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE REGENERATION; WESTERN BLOTTING; ZEBRA FISH; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GLIA; MACROGLIA; NERVE REGENERATION; NERVOUS SYSTEM DEVELOPMENT; PHYSIOLOGY; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL PROLIFERATION; EPENDYMOGLIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; MALE; NERVE REGENERATION; NEURAL STEM CELLS; NEUROGENESIS; NEUROGLIA; RECEPTORS, NOTCH; RETINAL NEURONS; TUMOR NECROSIS FACTOR-ALPHA; ZEBRAFISH;

EID: 84908079385     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0498-14.2014     Document Type: Article

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