Mutant hypoxia-inducible factor 1α modified bone marrow mesenchymal stem cells ameliorate cerebral ischemia

International Journal of Molecular Medicine

Volumn 34, Issue 6, 2014, Pages 1622-1628

  Yang, Chunyu ^a   Liu, Hua ^a   Liu, Danping ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Bone marrow mesenchymal stem cells; Cerebral ischemia; Mutant HIF1

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MUTANT PROTEIN; TRIPHENYLTETRAZOLIUM; VASCULOTROPIN; VASCULOTROPIN A;

ADULT; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CAPILLARY DENSITY; CELL HYPOXIA; CEREBRAL REVASCULARIZATION; CONTROLLED STUDY; GENE; HIF1ALPHA GENE; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR PERFORMANCE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; ANIMAL; ANOXIA; BONE MARROW CELL; BRAIN; CEREBRAL INFARCTION; CYTOLOGY; GENETICS; HEK293 CELL LINE; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; MICROVASCULATURE; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT; TIME; VASCULARIZATION;

ANIMALS; ANOXIA; BASE SEQUENCE; BLOTTING, WESTERN; BONE MARROW CELLS; BRAIN; BRAIN ISCHEMIA; CEREBRAL INFARCTION; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICROVESSELS; MUTATION, MISSENSE; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84908066312     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1953     Document Type: Article

References (29)

1. Giaccia A, Siim BG and Johnson RS: HIF-1 as a target for drug development. Nat Rev Drug Discov 2: 803-811, 2003.
2. Khan TA, Sellke FW and Laham RJ: Gene therapy progress and prospects: therapeutic angiogenesis for limb and myocardial ischemia. Gene Ther 10: 285-291, 2003.
3. Semenza GL: Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today 12: 853-859, 2007.
4. Wan C, Gilbert SR, Wang Y, et al: Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration. Proc Natl Acad Sci USA 105: 686-691, 2008.
5. Pugh CW and Ratcliffe PJ: Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9: 677-684, 2003.
6. Majmundar AJ, Wong WJ and Simon MC: Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 40: 294-309, 2010.
7. 2 tension. Proc Natl Acad Sci USA 92: 5510-5514, 1995
8. Fiorenzo P, Mongiardi MP, Dimitri D, et al: HIF1-positive and HIF1-negative glioblastoma cells compete in vitro but cooperate in tumor growth in vivo. Int J Oncol 36: 785-791, 2010.
9. Giatromanolaki A, Fiska A, Pitsiava D., Kartalis G, Kouourakis MI and Sivridis E: Erythropoietin receptors in endometrial carcinoma as related to HIF1α and VEGF expression. In vivo 23: 699-703, 2009
10. Rey S and Semenza GL: Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. Cardiovasc Res 86: 236-242, 2010.
11. Bruick RK and McKnight SL: A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337-1340, 2001.
12. Dang EV, Barbi J, Yang H.Y., et al: Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146: 772-784, 2011.
13. Evans CE, Humphries J, Mattock K., et al: Hypoxia and upregu-lation of hypoxia-inducible factor 1α stimulate venous thrombus recanalization. Arterioscler Thromb Vasc Biol 30: 2443-2451, 2010.
14. Kazi AA, Molitoris KH and Koos RD: Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus. Biol Reprod 81: 378-387, 2009
15. Lando D, Peet DJ, Whelan D.A., Gorman JJ and Whitelaw ML: Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295: 858-861, 2002.
16. Ralph GS, Parham S, Lee S.R., et al: Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1α and HIF-2α in a primary neuronal model of hypoxia. J Cereb Blood Flow Metab 24: 245-258, 2004
17. Longa EZ, Weinstein PR, Carlson S, Cummins R., et al: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91, 1989
18. Liu N, Zhang Y, Fan L., et al: Effects of transplantation with bone marrow-derived mesenchymal stem cells modified by Survivin on experimental stroke in rats. J Transl Med 9: 105, 2011.
19. + and CD34-cord blood cells. Ger Med Sci 3: Doc09, 2005
20. Neumann-Haefelin T., Kastrup A, de Crespigny A, Yenari MA, Ringer T, Sun GH and Moseley ME: Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke 31: 1965-1972, 2000.
21. Weidner N, Semple J P, Welch WR and Folkman J: Tumor angio-genesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324: 1-8, 1991.
22. Mustafa AK, Ahmad AS, Zeynalov E, et al: Serine racemase deletion protects against cerebral ischemia and excitotoxicity. J Neurosci 30: 1413-1416, 2010.
23. Ruiz-Crespo S., Trejo-Gabriel-Galán JM and Coma-del-Corral MJ: Localizing coordinates of cerebral ischemic tissue without the need of staining in a rat model of focal cerebral infarct. Metab Brain Dis 28: 21-24, 2013.
24. Yu J, Zhu H, Ko D and Kindy MS: Motoneuronotrophic factor analog GM6 reduces infarct volume and behavioral deficits following transient ischemia in the mouse. Brain Res 1238: 143-153, 2008.
25. Elson DA, Thurston G, Huang L.E., Ginzinger DG, McDonald DM, Johnson RS and Arbeit JM: Induction of hyper-vascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α. Genes Dev 15: 2520-2532, 2001.
26. Menge T, Zhao Y, Zhao J., et al: Mesenchymal stem cells regulate blood-brain barrier integrity through TIMP3 release after traumatic brain injury. Sci Transl Med 4: 161ra150, 2012.
27. Pati S, Khakoo AY, Zhao J, et al: Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling. Stem Cells Dev 20: 89-101, 2011.
28. Warach S and Latour LL: Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption. Stroke 35: 2659-2661, 2004.
29. Zacharek A, Chen J, Cui X., et al: Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. J Cereb Blood Flow Metab 27: 1684-1691, 2007.