메뉴 건너뛰기




Volumn 24, Issue 10, 2014, Pages 1659-1675

N-acetyl-aspartate (NAA) as a correlate of pharmacological treatment in psychiatric disorders: A systematic review

Author keywords

Affective disorder; Alzheimer dementia; N acetyl aspartate; Obsessive compulsive disorder; Proton MR spectroscopy; Schizophrenia

Indexed keywords

CHLORPROMAZINE; CITALOPRAM; CLOZAPINE; DONEPEZIL; DULOXETINE; ESCITALOPRAM; FLUOXETINE; GALANTAMINE; HALOPERIDOL; ICOSAPENTAENOIC ACID; LITHIUM; N ACETYLASPARTIC ACID; NEUROLEPTIC AGENT; NORTRIPTYLINE; OLANZAPINE; PAROXETINE; QUETIAPINE; RISPERIDONE; RIVASTIGMINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; VALPROIC ACID; VENLAFAXINE; ASPARTIC ACID; N-ACETYLASPARTATE;

EID: 84908053444     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2014.06.004     Document Type: Article
Times cited : (56)

References (50)
  • 2
    • 67349270567 scopus 로고    scopus 로고
    • Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells
    • Arun P., Moffett J.R., Namboodiri A.M. Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells. Neurochem. Int. 2009, 55:219-225.
    • (2009) Neurochem. Int. , vol.55 , pp. 219-225
    • Arun, P.1    Moffett, J.R.2    Namboodiri, A.M.3
  • 4
    • 78449291633 scopus 로고    scopus 로고
    • Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain[U+05F3]s "operating system": how NAA metabolism supports meaningful intercellular frequency-encoded communications
    • Baslow M.H. Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain[U+05F3]s "operating system": how NAA metabolism supports meaningful intercellular frequency-encoded communications. Amino Acids 2010, 39:1139-1145.
    • (2010) Amino Acids , vol.39 , pp. 1139-1145
    • Baslow, M.H.1
  • 5
    • 0037409849 scopus 로고    scopus 로고
    • N-acetylaspartate in the vertebrate brain: metabolism and function
    • Baslow M.H. N-acetylaspartate in the vertebrate brain: metabolism and function. Neurochem. Res. 2003, 28:941-953.
    • (2003) Neurochem. Res. , vol.28 , pp. 941-953
    • Baslow, M.H.1
  • 6
    • 0029767436 scopus 로고    scopus 로고
    • Inhibition of N-acetylaspartate production: implications for 1H-MRS studies in vivo
    • Bates T.E., Strangward M., Keelan J., Davey G.P., Munro P.M., Clark J.B. Inhibition of N-acetylaspartate production: implications for 1H-MRS studies in vivo. Neuroreport 1996, 7:1397-1400.
    • (1996) Neuroreport , vol.7 , pp. 1397-1400
    • Bates, T.E.1    Strangward, M.2    Keelan, J.3    Davey, G.P.4    Munro, P.M.5    Clark, J.B.6
  • 8
    • 66449108573 scopus 로고    scopus 로고
    • Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response
    • Block W., Träber F., von Widdern O., Metten M., Schild H., Maier W., Zobel A., Jessen F. Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response. Int. J. Neuropsychopharmacol. 2009, 12:415-422.
    • (2009) Int. J. Neuropsychopharmacol. , vol.12 , pp. 415-422
    • Block, W.1    Träber, F.2    von Widdern, O.3    Metten, M.4    Schild, H.5    Maier, W.6    Zobel, A.7    Jessen, F.8
  • 9
    • 0026922604 scopus 로고
    • Practical applications of chemical shift imaging
    • Brown T.R. Practical applications of chemical shift imaging. NMR Biomed. 1992, 5:238-243.
    • (1992) NMR Biomed. , vol.5 , pp. 238-243
    • Brown, T.R.1
  • 10
    • 0036888751 scopus 로고    scopus 로고
    • Longitudinal follow-up of neurochemical changes during the first year of antipsychotic treatment in schizophrenia patients with minimal previous medication exposure
    • Bustillo J.R., Lauriello J., Rowland L.M., Thomson L.M., Petropoulos H., Hammond R., Hart B., Brooks W.M. Longitudinal follow-up of neurochemical changes during the first year of antipsychotic treatment in schizophrenia patients with minimal previous medication exposure. Schizophr. Res. 2002, 58:313-321.
    • (2002) Schizophr. Res. , vol.58 , pp. 313-321
    • Bustillo, J.R.1    Lauriello, J.2    Rowland, L.M.3    Thomson, L.M.4    Petropoulos, H.5    Hammond, R.6    Hart, B.7    Brooks, W.M.8
  • 14
    • 0031731910 scopus 로고    scopus 로고
    • N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction
    • Clark J.B. N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction. Dev. Neurosci. 1998, 20:271-276.
    • (1998) Dev. Neurosci. , vol.20 , pp. 271-276
    • Clark, J.B.1
  • 15
    • 0034068954 scopus 로고    scopus 로고
    • Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid
    • Dautry C., Vaufrey F., Brouillet E., Bizat N., Henry P.G., Condé F., Bloch G., Hantraye P. Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid. J. Cereb. Blood Flow Metab. 2000, 20:789-799.
    • (2000) J. Cereb. Blood Flow Metab. , vol.20 , pp. 789-799
    • Dautry, C.1    Vaufrey, F.2    Brouillet, E.3    Bizat, N.4    Henry, P.G.5    Condé, F.6    Bloch, G.7    Hantraye, P.8
  • 16
    • 33745643161 scopus 로고    scopus 로고
    • Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study
    • DelBello M.P., Cecil K.M., Adler C.M., Daniels J.P., Strakowski S.M. Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study. Neuropsychopharmacology 2006, 31:1264-1273.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1264-1273
    • DelBello, M.P.1    Cecil, K.M.2    Adler, C.M.3    Daniels, J.P.4    Strakowski, S.M.5
  • 18
    • 34447564983 scopus 로고    scopus 로고
    • Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder
    • Frangou S., Lewis M., Wollard J., Simmons A. Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder. J. Psychopharmacol. 2007, 21:435-439.
    • (2007) J. Psychopharmacol. , vol.21 , pp. 435-439
    • Frangou, S.1    Lewis, M.2    Wollard, J.3    Simmons, A.4
  • 21
    • 79952010905 scopus 로고    scopus 로고
    • Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder
    • (A)
    • Henigsberg N., Bajs M., Hrabac P., Kalember P., Rados M., Rados M., Radonić E. Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder. Coll. Antropol. 2011, 35(Suppl. 1):145-148. (A).
    • (2011) Coll. Antropol. , vol.35 , pp. 145-148
    • Henigsberg, N.1    Bajs, M.2    Hrabac, P.3    Kalember, P.4    Rados, M.5    Rados, M.6    Radonić, E.7
  • 22
    • 79952021640 scopus 로고    scopus 로고
    • 1-H MRS changes in dorsolateral prefrontal cortex after donepezil treatment in patients with mild to moderate Alzheimer[U+05F3]s disease
    • Henigsberg N., Kalember P., Hrabać P., Rados M., Bajs M., Rados M., Kovavić Z., Loncar M., Madzar T. 1-H MRS changes in dorsolateral prefrontal cortex after donepezil treatment in patients with mild to moderate Alzheimer[U+05F3]s disease. Coll. Antropol. 2011, 35(Suppl. 1):159-162.
    • (2011) Coll. Antropol. , vol.35 , pp. 159-162
    • Henigsberg, N.1    Kalember, P.2    Hrabać, P.3    Rados, M.4    Bajs, M.5    Rados, M.6    Kovavić, Z.7    Loncar, M.8    Madzar, T.9
  • 23
    • 77950044103 scopus 로고    scopus 로고
    • Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: a study using (1)H magnetic resonance spectroscopy
    • Huang Y., Chen W., Li Y., Wu X., Shi X., Geng D. Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: a study using (1)H magnetic resonance spectroscopy. Psychiatry Res. 2010, 182:48-52.
    • (2010) Psychiatry Res. , vol.182 , pp. 48-52
    • Huang, Y.1    Chen, W.2    Li, Y.3    Wu, X.4    Shi, X.5    Geng, D.6
  • 24
    • 33746902788 scopus 로고    scopus 로고
    • A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder
    • Jang J.H., Kwon J.S., Jang D.P., Moon W.J., Lee J.M., Ha T.H., Chung E.C., Kim I.Y., Kim S.I. A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder. Am. J. Psychiatry 2006, 163:1202-1207.
    • (2006) Am. J. Psychiatry , vol.163 , pp. 1202-1207
    • Jang, J.H.1    Kwon, J.S.2    Jang, D.P.3    Moon, W.J.4    Lee, J.M.5    Ha, T.H.6    Chung, E.C.7    Kim, I.Y.8    Kim, S.I.9
  • 25
    • 33747038088 scopus 로고    scopus 로고
    • Treatment monitoring and response prediction with proton MR spectroscopy in AD
    • Jessen F., Traeber F., Freymann K., Maier W., Schild H.H., Block W. Treatment monitoring and response prediction with proton MR spectroscopy in AD. Neurology 2006, 67:528-530.
    • (2006) Neurology , vol.67 , pp. 528-530
    • Jessen, F.1    Traeber, F.2    Freymann, K.3    Maier, W.4    Schild, H.H.5    Block, W.6
  • 26
    • 65649090233 scopus 로고    scopus 로고
    • Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naive female patients with first-episode major depression
    • Kaymak S.U., Demir B., Oguz K.K., Senturk S., Ulug B. Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naive female patients with first-episode major depression. Psychiatry Clin. Neurosci. 2009, 63:350-356.
    • (2009) Psychiatry Clin. Neurosci. , vol.63 , pp. 350-356
    • Kaymak, S.U.1    Demir, B.2    Oguz, K.K.3    Senturk, S.4    Ulug, B.5
  • 27
    • 1842830710 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer[U+05F3]s disease
    • Krishnan K.R., Charles H.C., Doraiswamy P.M., Mintzer J., Weisler R., Yu X., Perdomo C., Ieni J.R., Rogers S. Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer[U+05F3]s disease. Am. J. Psychiatry 2003, 160:2003-2011.
    • (2003) Am. J. Psychiatry , vol.160 , pp. 2003-2011
    • Krishnan, K.R.1    Charles, H.C.2    Doraiswamy, P.M.3    Mintzer, J.4    Weisler, R.5    Yu, X.6    Perdomo, C.7    Ieni, J.R.8    Rogers, S.9
  • 30
    • 0028361905 scopus 로고
    • Automated processing for proton spectroscopic imaging using water reference deconvolution
    • Maudsley A.A., Wu Z., Meyerhoff D.J., Weiner M.W. Automated processing for proton spectroscopic imaging using water reference deconvolution. Magn. Reson. Med. 1994, 31:589-595.
    • (1994) Magn. Reson. Med. , vol.31 , pp. 589-595
    • Maudsley, A.A.1    Wu, Z.2    Meyerhoff, D.J.3    Weiner, M.W.4
  • 31
    • 0038050597 scopus 로고    scopus 로고
    • Neurotrophic effects of electroconvulsive therapy: a proton magnetic resonance study of the left amygdalar region in patients with treatment-resistant depression
    • Michael N., Erfurth A., Ohrmann P., Arolt V., Heindel W., Pfleiderer B. Neurotrophic effects of electroconvulsive therapy: a proton magnetic resonance study of the left amygdalar region in patients with treatment-resistant depression. Neuropsychopharmacology 2003, 28:720-725.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 720-725
    • Michael, N.1    Erfurth, A.2    Ohrmann, P.3    Arolt, V.4    Heindel, W.5    Pfleiderer, B.6
  • 32
    • 33749245441 scopus 로고    scopus 로고
    • Changes in metabolite ratios after treatment with rivastigmine in Alzheimer[U+05F3]s disease: a nonrandomised controlled trial with magnetic resonance spectroscopy
    • Modrego P.J., Pina M.A., Fayed N., Diaz M. Changes in metabolite ratios after treatment with rivastigmine in Alzheimer[U+05F3]s disease: a nonrandomised controlled trial with magnetic resonance spectroscopy. CNS Drugs 2006, 20:867-877.
    • (2006) CNS Drugs , vol.20 , pp. 867-877
    • Modrego, P.J.1    Pina, M.A.2    Fayed, N.3    Diaz, M.4
  • 37
    • 11144221598 scopus 로고    scopus 로고
    • Interdependence of N-acetyl aspartate and high-energy phosphates in healthy human brain
    • Pan J.W., Takahashi K. Interdependence of N-acetyl aspartate and high-energy phosphates in healthy human brain. Ann. Neurol. 2005, 57:92-97.
    • (2005) Ann. Neurol. , vol.57 , pp. 92-97
    • Pan, J.W.1    Takahashi, K.2
  • 38
    • 70349633251 scopus 로고    scopus 로고
    • Neurometabolic correlations of donepezil and rivastigmine in dementia patients: a different neuroprotective effect
    • Parlayan E., Yulug B., Bakar M., Gumustas O. Neurometabolic correlations of donepezil and rivastigmine in dementia patients: a different neuroprotective effect. J. Neuropsychiatry Clin. Neurosci. 2009, 21:348-350.
    • (2009) J. Neuropsychiatry Clin. Neurosci. , vol.21 , pp. 348-350
    • Parlayan, E.1    Yulug, B.2    Bakar, M.3    Gumustas, O.4
  • 40
    • 77956068844 scopus 로고    scopus 로고
    • N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: a study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects
    • Premkumar P., Parbhakar V.A., Fannon D., Lythgoe D., Williams S.C., Kuipers E., Kumari V. N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: a study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects. Psychiatry Res. 2010, 182:251-260.
    • (2010) Psychiatry Res. , vol.182 , pp. 251-260
    • Premkumar, P.1    Parbhakar, V.A.2    Fannon, D.3    Lythgoe, D.4    Williams, S.C.5    Kuipers, E.6    Kumari, V.7
  • 42
    • 0034055660 scopus 로고    scopus 로고
    • On the reliability of quantitative clinical magnetic resonance spectroscopy of the human brain
    • Schirmer T., Auer D.P. On the reliability of quantitative clinical magnetic resonance spectroscopy of the human brain. NMR Biomed. 2000, 13:28-36.
    • (2000) NMR Biomed. , vol.13 , pp. 28-36
    • Schirmer, T.1    Auer, D.P.2
  • 43
    • 0032819613 scopus 로고    scopus 로고
    • Compounds containing cytosolic choline in the basal ganglia: a potential biological marker of true drug response to fluoxetine
    • Sonawalla S.B., Renshaw P.F., Moore C.M., Alpert J.E., Nierenberg A.A., Rosenbaum J.F., Fava M. Compounds containing cytosolic choline in the basal ganglia: a potential biological marker of true drug response to fluoxetine. Am. J. Psychiatry 1999, 156(10):1638-1640.
    • (1999) Am. J. Psychiatry , vol.156 , Issue.10 , pp. 1638-1640
    • Sonawalla, S.B.1    Renshaw, P.F.2    Moore, C.M.3    Alpert, J.E.4    Nierenberg, A.A.5    Rosenbaum, J.F.6    Fava, M.7
  • 44
    • 26244458916 scopus 로고    scopus 로고
    • The effect of risperidone on metabolite measures in the frontal lobe, temporal lobe, and thalamus in schizophrenic patients. A proton magnetic resonance spectroscopy (1H-MRS)
    • Szulc A., Galinska B., Tarasow E., Dzienis W., Kubas B., Konarzewska B., Walecki J., Alathiaki A.S., Czernikiewicz A. The effect of risperidone on metabolite measures in the frontal lobe, temporal lobe, and thalamus in schizophrenic patients. A proton magnetic resonance spectroscopy (1H-MRS). Pharmacopsychiatry 2005, 38:214-219.
    • (2005) Pharmacopsychiatry , vol.38 , pp. 214-219
    • Szulc, A.1    Galinska, B.2    Tarasow, E.3    Dzienis, W.4    Kubas, B.5    Konarzewska, B.6    Walecki, J.7    Alathiaki, A.S.8    Czernikiewicz, A.9
  • 46
    • 84867242369 scopus 로고    scopus 로고
    • Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1H-magnetic resonance spectroscopy of N-acetyl-aspartate
    • Taylor M.J., Godlewska B.R., Norbury R., Selvaraj S., Cowen J. Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1H-magnetic resonance spectroscopy of N-acetyl-aspartate. Int. J. Neuropsychopharmacol. 2012, 15:1541-1546.
    • (2012) Int. J. Neuropsychopharmacol. , vol.15 , pp. 1541-1546
    • Taylor, M.J.1    Godlewska, B.R.2    Norbury, R.3    Selvaraj, S.4    Cowen, J.5
  • 48
    • 0026633564 scopus 로고
    • Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro
    • Urenjak J., Williams S.R., Gadian D.G., Noble M. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J. Neurochem. 1992, 59:55-61.
    • (1992) J. Neurochem. , vol.59 , pp. 55-61
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 49
    • 84867501682 scopus 로고    scopus 로고
    • Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: effects of treatment
    • Wang Y., Jia Y., Chen X., Ling X., Liu S., Xu G., Huang L. Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: effects of treatment. J. Psychopharmacol. 2012, 26:1463-1470.
    • (2012) J. Psychopharmacol. , vol.26 , pp. 1463-1470
    • Wang, Y.1    Jia, Y.2    Chen, X.3    Ling, X.4    Liu, S.5    Xu, G.6    Huang, L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.