Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 42, 2014, Pages 15114-15119

  Leung, Yvonne ^a,b   Kandyba, Eve ^a,b   Chen, Yi Bu ^b   Ruffins, Seth ^a   Chuong, Cheng Ming ^b,c   Kobielak, Krzysztof ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

BMP signaling; Nail proximal fold stem cells; Nail stem cells; Skin stem cells

Indexed keywords

BONE MORPHOGENETIC PROTEIN; GREEN FLUORESCENT PROTEIN;

ANIMAL; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CYTOLOGY; ECTODERM; EPIDERMIS; GENETIC TRANSCRIPTION; HOMEOSTASIS; HOOF AND CLAW; KNOCKOUT MOUSE; METABOLISM; MOUSE; REGENERATION; SIGNAL TRANSDUCTION; STEM CELL; WOUND HEALING;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; ECTODERM; EPIDERMIS; GREEN FLUORESCENT PROTEINS; HOMEOSTASIS; HOOF AND CLAW; MICE; MICE, KNOCKOUT; REGENERATION; SIGNAL TRANSDUCTION; STEM CELLS; TRANSCRIPTION, GENETIC; WOUND HEALING;

EID: 84908032941     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318848111     Document Type: Article

References (30)

1. Chueh SC, et al. (2013) Therapeutic strategy for hair regeneration: Hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering. Expert Opin Biol Ther 13(3):377-391.
2. Leung Y, Kandyba E, Chen YB, Ruffins S, Kobielak K (2013) Label retaining cells (LRCs) with myoepithelial characteristic from the proximal acinar region define stem cells in the sweat gland. PLoS ONE 8(9):e74174.
3. Lu CP, et al. (2012) Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair. Cell 150(1):136-150.
4. Zaias N, Alvarez J (1968) The formation of the primate nail plate. An autoradiographic study in squirrel monkey. J Invest Dermatol 51(2):120-136.
5. Cotsarelis G, Sun TT, Lavker RM (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61(7):1329-1337.
6. Cotsarelis G, Cheng SZ, Dong G, Sun TT, Lavker RM (1989) Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: Implications on epithelial stem cells. Cell 57(2):201-209.
7. Nakamura M, Tokura Y (2009) The localization of label-retaining cells in eccrine glands. J Invest Dermatol 129(8):2077-2078.
8. Takeo M, et al. (2013) Wnt activation in nail epithelium couples nail growth to digit regeneration. Nature 499(7457):228-232.
9. Diamond I, Owolabi T, Marco M, Lam C, Glick A (2000) Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. J Invest Dermatol 115(5):788-794.
10. Tumbar T, et al. (2004) Defining the epithelial stem cell niche in skin. Science 303(5656):359-363.
11. Nakamura M, Ishikawa O (2008) The localization of label-retaining cells in mouse nails. J Invest Dermatol 128(3):728-730.
12. Morris RJ, et al. (2004) Capturing and profiling adult hair follicle stem cells. Nat Biotechnol 22(4):411-417.
13. Madisen L, et al. (2010) A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133-140.
14. Mao X, Fujiwara Y, Orkin SH (1999) Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci USA 96(9):5037-5042.
15. Sellheyer K, Nelson P (2012) The ventral proximal nail fold: Stem cell niche of the nail and equivalent to the follicular bulge - a study on developing human skin. J Cutan Pathol 39(9):835-843.
16. Kobielak K, Stokes N, de la Cruz J, Polak L, Fuchs E (2007) Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci USA 104(24):10063-10068.
17. Kobielak K, Pasolli HA, Alonso L, Polak L, Fuchs E (2003) Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol 163(3):609-623.
18. Kandyba E, et al. (2013) Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Proc Natl Acad Sci USA 110(4):1351-1356.
19. Kandyba E, Hazen VM, Kobielak A, Butler SJ, Kobielak K (2014) Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state. Stem Cells 32(2):534-547.
20. Andl T, et al. (2004) Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development 131(10):2257-2268.
21. Plikus MV, et al. (2008) Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451(7176):340-344.
22. Cai J, Ma L (2011) Msx2 and Foxn1 regulate nail homeostasis. Genesis 49(6):449-459.
23. Godwin AR, Capecchi MR (1998) Hoxc13 mutant mice lack external hair. Genes Dev 12(1):11-20.
24. Mecklenburg L, et al. (2004) FOXN1 is critical for onycholemmal terminal differentiation in nude (Foxn1) mice. J Invest Dermatol 123(6):1001-1011.
25. Hsu YC, Pasolli HA, Fuchs E (2011) Dynamics between stem cells, niche, and progeny in the hair follicle. Cell 144(1):92-105.
26. Chuong CM, Widelitz RB (2009) The river of stem cells. Cell Stem Cell 4(2):100-102.
27. Ito M, et al. (2005) Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med 11(12):1351-1354.
28. Wu P, et al. (2004) Evo-Devo of amniote integuments and appendages. Int J Dev Biol 48(2-3):249-270.
29. Mishina Y, Hanks MC, Miura S, Tallquist MD, Behringer RR (2002) Generation of Bmpr/Alk3 conditional knockout mice. Genesis 32(2):69-72.
30. Vasioukhin V, Degenstein L, Wise B, Fuchs E (1999) The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci USA 96(15):8551-8556.