Mice lacking GD3 synthase display morphological abnormalities in the sciatic nerve and neuronal disturbances during peripheral nerve regeneration

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Ribeiro Resende, Victor Túlio ^a   Gomes, Tiago Araújo ^a   De Lima, Silmara ^a   Nascimento Lima, Maiara ^a   Bargas Rega, Michele ^a   Santiago, Marcelo Felipe ^a   De Melo Reis, Ricardo Augusto ^a   De Mello, Fernando Garcia ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GANGLIOSIDE GD3; MYELIN BASIC PROTEIN; TOLONIUM CHLORIDE; 9-O-ACETYL-GD3 GANGLIOSIDE; ALPHA-N-ACETYLNEURAMINATE ALPHA-2,8-SIALYLTRANSFERASE; BETA1 INTEGRIN; GANGLIOSIDE; SIALYLTRANSFERASE;

ADULT; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; MALE; MOUSE; MYELINATION; NERVE FIBER GROWTH; NERVE REGENERATION; NEUROLOGIC DISEASE; NONHUMAN; PERIPHERAL NERVE; PROTEIN EXPRESSION; SCHWANN CELL; SCIATIC NERVE; SIGNAL TRANSDUCTION; THICKNESS; WALLERIAN DEGENERATION; ANIMAL; CELL COUNT; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENE INACTIVATION; GENETICS; METABOLISM; MOTOR ACTIVITY; MYELIN SHEATH; NERVE CELL; NERVE FIBER; PHYSIOLOGY;

MUS;

ANIMALS; ANTIGENS, CD29; AXONS; CELL COUNT; FEMALE; GANGLIOSIDES; GENE KNOCKOUT TECHNIQUES; MALE; MICE; MOTOR ACTIVITY; MYELIN SHEATH; NERVE REGENERATION; NEURONS; SCIATIC NERVE; SIALYLTRANSFERASES;

EID: 84908032939     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108919     Document Type: Article

References (34)

1. Todeschini RA, Hakomori SI (2008) Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains. Biochim Biophys Acta 1780:421-33.
2. Mendez-Otero R, Friedman JE (1996) Role of acetylated gangliosides on neurite extension. Eur J Cell Biol 71:192-8.
3. Bovolenta P, Fernaud-Espinosa I, Mendez-Otero R, Nieto-Sampedro M (1997) Neurite outgrowth inhibitor of gliotic brain tissue. Mode of action and cellular localization, studied with specific monoclonal antibodies. Eur J Neurosci 9:977-89.
4. Mendez-Otero R, Cavalcante LA (2002) Functional role of gangliosides in neuronal motility. Prog Mol Subcell Biol 32:97-124.
5. Schlosshauer B, Blum AS, Mendez-Otero R, Barnstable CJ, Constantine-Paton M (1998) Developmental regulation of ganglioside antigens recognized by the JONES antibody. J Neurosci 8:580-92.
6. Chen HY, Challa AK, Varki A (2006) 9-O-acetylation of exogenously added ganglioside GD3. The GD3 molecule induces its own O-acetylation machinery. J Biol Chem 281:7825-33.
7. Satake H, Chen HY, Varki A (2003) Genes modulated by expression of GD3 synthase in Chinese hamster ovary cells. Evidence that the Tis21 gene is involved in the induction of GD3 9-O-acetylation. J Biol Chem 278:7942-8.
8. Santiago MF, Costa MR, Mendez-Otero R (2004) Immunoblockage of 9-Oacetyl GD3 ganglioside arrests the in vivo migration of cerebellar granule neurons. J Neurosci 24:474-8.
9. Santiago MF, Berredo-Pinho M, Costa MR, Gandra M, Cavalcante LA, et al. (2009) Expression and function of ganglioside 9-O-acetyl GD3 in postmitotic granule cell development. Mol Cell Neurosci 17:488-99.
10. Ribeiro-Resende VT, Oliveira-Silva A, Ouverney-Brandão S, Santiago MF, Hedin-Pereira C, et al. (2007) Ganglioside 9-O-acetyl GD3 expression is upregulated in the regenerating peripheral nerve. Neuroscience 147:97-105.
11. Miyakoshi LM, Todeschini AR, Mendez-Otero R, Hedin-Pereira C (2012) Role of the 9-O-acetyl GD3 in subventricular zone neuroblast migration. Mol Cell Neurosci 49:240-9.
12. Araújo H, Menezes M, Mendez-Otero R (1997) Blockage of 9-O-acetyl gangliosides induces microtubule depolymerization in growth cones and neurites. Eur J Cell Biol 72:202-13.
13. Okada M, Itoh Mi M, Haraguchi M, Okajima T, Inoue M, et al. (2001) b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. J Biol Chem 277:1633-6.
14. Wallquist W, Patarroyo M, Thams S, Carlstedt T, Stark B, et al. (2002) Laminin chains in rat and human peripheral nerve: distribution and regulation during development and after axonal injury. J Comp Neurol 454:284-93.
15. Negreiros EM, Leão AC, Santiago MF, Mendez-Otero R (2003) Localization of ganglioside 9-O-acetyl GD3 in point contacts of neuronal growth cones. J Neurobiol 57:31-7.
16. Ribeiro-Resende VT, Ribeiro-Guimarães ML, Lemes RM, Nascimento IC, Alves L, et al. (2010) Involvement of 9-O-Acetyl GD3 ganglioside in Mycobacterium leprae infection of Schwann cells. J Biol Chem 285:34086-96.
17. Tapinos N, Ohnishi M, Rambukkana A (2006) ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli. Nat Med 12:961-6.
18. De Melo Reis RA, Schitine CS, Köfalvi A, Grade S, Cortes L, et al. (2011) Functional identification of cell phenotypes differentiating from mice retinal neurospheres using single cell calcium imaging. Cell Mol Neurobiol 31:835-46.
19. Brosenitsch TA, Salgado-Commissariat D, Kunze DL, Katz DM (1998) A role for L-type calcium channels in developmental regulation of transmitter phenotype in primary sensory neurons. J Neurosci 18:1047-55.
20. Fields RD, Burnstock G (2006) Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci 7:423-36.
21. Paratcha G, Ibáñez CF (2002) Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme. Curr Opin Neurobiol 12:542-9.
22. Tillman TS, Cascio M (2003) Effects of membrane lipids on ion channel structure and function. Cell Biochem Biophys 38:161-90.
23. Gomez TM, Robles E, Poo M, Spitzer NC (2001) Filopodial calcium transients promote substrate-dependent growth cone turning. Science 291:1983-7.
24. Bixby JL, Grunwald GB, Bookman RJ (1994) Ca2+ influx and neurite growth in response to purified N-cadherin and laminin. J Cell Biol 127:1461-75.
25. Nave KA, Salzer JL (2006) Axonal regulation of myelination by neuregulin 1. Curr Opin Neurobiol 16:492-500.
26. Stassart RM, Fledrich R, Velanac V, Brinkmann BG, Schwab MH, et al. (2013) A role for Schwann cell-derived neuregulin-1 in remyelination. Nat Neurosci 16:48-54.
27. Michailov GV, Sereda MW, Brinkmann BG, Fischer TM, Haug B, et al. (2004) Axonal neuregulin-1 regulates myelin sheath thickness. Science 304:700-3.
28. Miyakoshi LM, Mendez-Otero R, Hedin-Pereira C (2001) The 9-O-acetyl GD3 gangliosides are expressed by migrating chains of subventricular zone neuronsin vitro. Braz J Med Biol Res 34:669-73.
29. Chen ZL, Yu WM, Strickland S (2007) Peripheral regeneration. Annu Rev Neurosci 30:209-33.
30. Blum AS, Barnstable CJ (1987) O-acetylation of a cell-surface carbohydrate creates discrete molecular patterns during neural development. Proc Natl Acad Sci U S A 84:8716-20.
31. Furukawa K, Aixinjueluo W, Kasama T, Ohkawa Y, Yoshihara M, et al. (2008) Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-Oacetyl GD3 irrespective of Tis21. J Neurochem 105:1057-66.
32. Suzuki Y, Yanagisawa M, Ariga T, Yu RK (2011) Histone acetylation-mediated glycosyltransferase gene regulation in mouse brain during development. J Neurochem 116:874-80.
33. Yu RK, Bieberich E, Xia T, Zeng G (2004) Regulation of ganglioside biosynthesis in the nervous system. J Lipid Res 45:783-93.
34. Hunskaar S, Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30:103-14.