The triglycerides-to-HDL-cholesterol ratio and cardiovascular disease risk in obese patients with type 2 diabetes: An observational study from the Swedish National Diabetes Register (NDR)

Diabetes Research and Clinical Practice

Volumn 106, Issue 1, 2014, Pages 136-144

  Eeg Olofsson, Katarina ^a   Gudbjörnsdottir, Soffia ^a   Eliasson, Björn ^a   Zethelius, Björn ^b   Cederholm, Jan ^c  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

BMI; Cardiovascular diseases; Diabetes; Insulin resistance; Obesity

Indexed keywords

HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; ORAL ANTIDIABETIC AGENT; TRIACYLGLYCEROL; BIOLOGICAL MARKER; HDL-TRIGLYCERIDE; HIGH DENSITY LIPOPROTEIN;

ADULT; AGE; ALBUMINURIA; ANAMNESIS; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR PARAMETERS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE DURATION; DISEASE REGISTRY; EXERCISE; FEMALE; GENDER; HAZARD RATIO; HEMOGLOBIN BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OBSERVATIONAL STUDY; PHYSICAL ACTIVITY; RISK ASSESSMENT; RISK FACTOR; SMOKING; SWEDEN; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; TRIGLYCERIDE TO HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO; AGED; BLOOD; BLOOD PRESSURE; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; INSULIN RESISTANCE; PHYSIOLOGY; PROGNOSIS;

ADULT; AGED; BIOLOGICAL MARKERS; BLOOD PRESSURE; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN RESISTANCE; LIPOPROTEINS, HDL; MALE; MIDDLE AGED; OBESITY; PROGNOSIS; RISK FACTORS; TRIGLYCERIDES;

EID: 84908029477     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2014.07.010     Document Type: Article

References (47)

1. Ridderstrale M., Gudbjornsdottir S., Eliasson B., Nilsson P.M., Cederholm J. Obesity and cardiovascular risk factors in type 2 diabetes: results from the Swedish National Diabetes Register. J Intern Med 2006, 259:314-322.
2. Saydah S.H., Fradkin J., Cowie C.C. Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA 2004, 291:335-342.
3. Adams K.F., Schatzkin A., Harris T.B., Kipnis V., Mouw T., Leitzmann M.F., et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006, 355:763-778.
4. Berrington de Gonzalez A., Hartge P., Cerhan J.R., Flint A.J., Hannan L., et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med 2010, 363:2211-2219.
5. Jonsson S., Hedblad B., Engstrom G., Nilsson P., Berglund G., Janzon L. Influence of obesity on cardiovascular risk Twenty-three-year follow-up of 22,025 men from an urban Swedish population. Int J Obes Relat Metab Disord 2002, 26:1046-1053.
6. Whitlock G., Lewington S., Sherliker P., Clarke R., Emberson J., Peto R., et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009, 373:1083-1096.
7. Flegal K.M., Kit B.K., Orpana H., Graubard B.I. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA 2013, 309:71-82.
8. Thomas F., Bean K., Pannier B., Oppert J.M., Guize L., Benetos A. Cardiovascular mortality in overweight subjects: the key role of associated risk factors. Hypertension 2005, 46:654-659.
9. Cho E., Manson J.E., Stampfer M.J., Solomon C.G., Colditz G.A., Hu F.B., et al. A prospective study of obesity and risk of coronary heart disease among diabetic women. Diabetes Care 2002, 25:1142-1148.
10. Eeg-Olofsson K., Cederholm J., Nilsson P.M., Zethelius B., Eliasson B., Gudbjörnsdottir S., et al. Risk of cardiovascular disease and mortality in overweight and obese patients with type 2 diabetes: an observational study in 13,087 patients. Diabetologia 2009, 52:65-73.
11. Mulnier H.E., Seaman H.E., Raleigh V.S., Soedamah-Muthu S.S., Colhoun H.M., De Vries C.S., et al. Risk of stroke in people with type 2 diabetes in the UK: a study using the General Practice Research Database. Diabetologia 2006, 49:2859-2865.
12. Zoppini G., Verlato G., Leuzinger C., Zamboni C., Brun E., Muggeo M., et al. Body mass index and the risk of mortality in type II diabetic patients from Verona. Int J Obes Relat Metab Disord 2003, 27:281-285.
13. Mulnier H.E., Seaman H.E., Raleigh V.S., Soedamah-Muthu S.S., Colhoun H.M., Lawrenson R.A. Mortality in people with type 2 diabetes in the UK. Diabet Med 2006, 23:516-521.
14. Logue J., Walker J.J., Leese G., Lindsay R., McKnight J., Sattar N., et al. The association between bmi measured within a year after diagnosis of type 2 diabetes and mortality. Diabetes Care 2013, 36:887-893.
15. Reaven G.M. Insulin resistance, compensatory hyperinsulinemia and coronary heart disease: syndrome X revisited. Handbook of physiology: section 7: the endocrine system. Volume II: the endocrine pancreas and regulation of metabolism 2001, 1169-1172. Oxford University Press. L.S. Jefferson, A.D. Chrington (Eds.).
16. Jeppsen J., Hein H.O., Suadicani P., Gyntelberg F. Relation of high TG-low HDL cholesterol and LDL cholesterol to the incidence of ischemic heart disease. Arterioscler Thromb Vasc Biol 1997, 17:1114-1120.
17. Gaziano J.M., Hennekens C.H., O.Donell C.J., Breslow J.L., Buring J.E. Fasting triglycerides, high-density lipoptotein, and risk of myocardial infarction. Circulation 1997, 96:2520-2525.
18. Scott R., Fulcher G., Pardy C., Taskinen M.-R., Enholm C., Keech A., et al. Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome. The FIELD study. Diabetes Care 2009, 32:493-498.
19. Eliasson B., Cederholm J., Eeg-Olofsson K., Svensson A.M., Zethelius B., Gudbjörnsdottir S. Clinical usefulness of different lipid measures for prediction of coronary heart disease in type 2 diabetes: a report from the Swedish National Diabetes Register. Diabetes Care 2011, 34:2095-2100.
20. Salazar M.R., Carbajal H.A., Espeche W.G., Aizpurua M., Leiva Sisnieguez C.E., Reaven G.M., et al. Identifying cardiovascular disease risk and outcome: use of the plasma triglyceride/high-density lipoprotein cholesterol concentration ratio versus metabolic syndrome criteria. J Intern Med 2013, 273:595-601.
21. Laws A., Reaven G.M. Evidence for an independent relationship between insulin resistance and fasting plasma HDL-cholesterol, triglyceride and insulin concentrations. J Intern Med 1992, 231:25-30.
22. McLaughlin T., Abbasi F., Cheal K., Chu J., Lamendola C., Reaven G.M., et al. Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med 2003, 139:802-809.
23. McLaughlin T., Reaven G., Abbasi F., Lamendola C., Saad M., Krauss R.M., et al. Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease. Am J Cardiol 2005, 96:399-404.
24. DeFronzo R.A. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links The Claude Bernard Lecture 2009. Diabetologia 2010, 53:1270-1287.
25. Razani B., Chakravarthy M.V., Semenkovich C.F. Insulin resistance and atherosclerosis. Endocrinol Metab Clin North Am 2008, 37:603-621.
26. Wassink A.M., van der Graaf Y., Olijhoek J.K., Visseren F.L. Metabolic syndrome and the risk of new vascular events and all-cause mortality in patients with coronary artery disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm. Eur Heart J 2008, 29:213-223.
27. Salazar M.R., Carbajal H.A., Espeche W.G., Leiva Sisnieguez C.E., Balbin E., Dulbecco C.A., et al. Relation among the plasma triglyceride/high-density lipoprotein cholesterol concentration ratio, insulin resistance, and associated cardio-metabolic risk factors in men and women. Am J Cardiol 2012, 109:1749-1753.
28. Salazar M.R., Carbajal H.A., Espeche W.G., Sisnieguez C.E.L., March C.E., Reaven G.M., et al. Comparison of the abilities of the plasma triglyceride/high-density lipoprotein cholesterol ratio and the metabolic syndrome to identify insulin resistance. Diab Vasc Dis Res 2013, 10:346-352.
29. Cederholm J., Gudbjornsdottir S., Eliasson B., Zethelius B., Eeg-Olofsson K., Nilsson P.N. Blood pressure and risk of cardiovascular diseases in type 2 diabetes: further findings from the Swedish National Diabetes Register (NDR-BP II). J Hypertens 2012, 30:2020-2030.
30. Gudbjornsdottir S., Eliasson B., Eeg-Olofsson K., Zethelius B., Cederholm J. Additive effects of glycaemia and dyslipidaemia on risk of cardiovascular diseases in type 2 diabetes: an observational study from the Swedish National Diabetes Register. Diabetologia 2011, 54:2544-2551.
31. Zethelius B., Eliasson B., Eeg-Olofsson K., Svensson A.M., Gudbjornsdottir S., Cederholm J. A new model for 5-year risk of cardiovascular disease in type 2 diabetes, from the Swedish National Diabetes Register (NDR). Diab Res Clin Pract 2011, 93:276-284.
32. Hoelzel W., Weykamp C., Jeppsson J.O., Miedema K., Barr J.R., Wiedmeyer H.M., et al. IFCC reference system for measurement of hemoglobin A1c in human blood and the national standardization schemes in the United States, Japan, and Sweden: a method-comparison study. Clin Chem 2004, 50:166-174.
33. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
34. Merlo J., Lindblad U., Pessah-Rasmussen H., Hedblad B., Rastam J., Isacsson S.O., et al. Comparison of different procedures to identify probable cases of myocardial infarction and stroke in two Swedish prospective cohort studies using local and national routine registers. Eur J Epidemiol 2000, 16:235-243.
35. Tunstall-Pedoe H., Kuulasmaa K., Amouyel P., Arveiler D., Rajakangas A.M., Pajak A. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation 1994, 90:583-612.
36. Ingelsson E., Arnlov J., Sundstrom J., Lind L. The validity of a diagnosis of heart failure in a hospital discharge register. Eur J Heart Fail 2005, 7:787-791.
37. Report of a WHO consultation Obesity: preventing and managing the global epidemic. World Health Organ Tech Rep Ser 2000, 894:1-253.
38. Standards of medical care in diabetes - 2014. Diabetes Care 2014, 37(Suppl. 1):S14-S80.
39. Unick J.L., Beavers D., Bond D.S., Clark J.M., Jakicic J.M., Knowler W.C., et al. The long-term effectiveness of a lifestyle intervention in severely obese individuals. Am J Med 2013, 126:236-242. e232.
40. Buchwald H., Estok R., Fahrbach K., Banel D., Jensen M.D., Sledge I., et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009, 122:248-256. e245.
41. Flum D.R., Belle S.H., King W.C., Wahed A.S., Berk P., Wolfe B., et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med 2009, 361:445-454.
42. Sjostrom L., Narbro K., Sjostrom C.D., Karason K., Larsson B., Wedel H., et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007, 357:741-752.
43. Romeo S., Maglio C., Burza M.A., Pirazzi C., Sjoholm K., Jacobson P., et al. Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetes. Diabetes Care 2012, 35:2613-2617.
44. Ortega F.B., Lee D.C., Katzmarzyk P.T., Ruiz J.R., Sui X., Church T.S., et al. The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness. Eur Heart J 2013, 34:389-397.
45. Turner R.C., Millns H., Neil H.A., Stratton I.M., Matthews D.R., Holman R.R., et al. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). BMJ 1998, 316:823-828.
46. Angeras O., Albertsson P., Karason K., Råmunddal T., Matejka G., Rosengren A., et al. Evidence for obesity paradox in patients with acute coronary syndromes: a report from the Swedish Coronary Angiography and Angioplasty Registry. Eur Heart J 2012, 34:345-353.
47. Fleischmann E., Teal N., Dudley J., May W., Bower J.D., Salahudeen A.K. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int 1999, 55:1560-1567.