메뉴 건너뛰기




Volumn 37, Issue 3, 2014, Pages 289-296

Metastatic Hormone refractory prostate cancer recent advances in standard treatment paradigm, and future directions

Author keywords

Metastatic hormone refractory prostate cancer; Recent advances; Standard treatments

Indexed keywords

ABIRATERONE; ANTIANDROGEN; ANTINEOPLASTIC AGENT; ATRASENTAN; BEVACIZUMAB; BISPHOSPHONIC ACID DERIVATIVE; CABAZITAXEL; CABOZANTINIB; CATHEPSIN K INHIBITOR; DASATINIB; DENOSUMAB; DOCETAXEL; LENALIDOMIDE; OSTEOCLAST DIFFERENTIATION FACTOR; RADIUM CHLORIDE RA 223; SARACATINIB; SIPULEUCEL T; TASQUINIMOD; ZIBOTENTAN; ANDROSTANE DERIVATIVE; ANGIOGENESIS INHIBITOR; CANCER VACCINE; CATHEPSIN K; ENDOTHELIN RECEPTOR; PROTEIN TYROSINE KINASE; RADIOPHARMACEUTICAL AGENT; TAXOID; TISSUE EXTRACT; VASCULOTROPIN RECEPTOR;

EID: 84908028642     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/COC.0b013e318248dc1e     Document Type: Review
Times cited : (6)

References (40)
  • 2
    • 34248169161 scopus 로고    scopus 로고
    • Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline
    • Loblaw DA, Virgo KS, Nam R, et al. Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline. J Clin Oncol. 2007;25: 1596-1605.
    • (2007) J Clin Oncol. , vol.25 , pp. 1596-1605
    • Loblaw, D.A.1    Virgo, K.S.2    Nam, R.3
  • 3
    • 0032497522 scopus 로고    scopus 로고
    • Bilateral orchiectomy with or without flutamide for metastatic prostate cancer
    • Eisenberger MA, Blumenstein BA, Crawford ED, et al. Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl J Med. 1998;339:1036-1042.
    • (1998) N Engl J Med. , vol.339 , pp. 1036-1042
    • Eisenberger, M.A.1    Blumenstein, B.A.2    Crawford, E.D.3
  • 4
    • 84856053991 scopus 로고    scopus 로고
    • Contemporary experience with ketoconazole in patients with metastatic castration resistant prostate cancer: Clinical factors associated with PSA response and disease progression
    • Keizman D, Huang P, Carducci MA, et al. Contemporary experience with ketoconazole in patients with metastatic castration resistant prostate cancer: clinical factors associated with PSA response and disease progression. Prostate. 2012;72:461-467.
    • (2012) Prostate , vol.72 , pp. 461-467
    • Keizman, D.1    Huang, P.2    Carducci, M.A.3
  • 5
    • 0042130389 scopus 로고    scopus 로고
    • Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663
    • Taplin ME, Rajeshkumar B, Halabi S, et al. Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. J Clin Oncol. 2003;21: 2673-2678.
    • (2003) J Clin Oncol. , vol.21 , pp. 2673-2678
    • Taplin, M.E.1    Rajeshkumar, B.2    Halabi, S.3
  • 6
    • 0037083472 scopus 로고    scopus 로고
    • Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy
    • July LV, Akbari M, Zellweger T, et al. Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy. Prostate. 2002;50:179-188.
    • (2002) Prostate , vol.50 , pp. 179-188
    • July, L.V.1    Akbari, M.2    Zellweger, T.3
  • 7
    • 0033022342 scopus 로고    scopus 로고
    • A mechanism for hormoneindependent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
    • Craft N, Shostak Y, Carey M, et al. A mechanism for hormoneindependent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat Med. 1999;5:280-285.
    • (1999) Nat Med. , vol.5 , pp. 280-285
    • Craft, N.1    Shostak, Y.2    Carey, M.3
  • 8
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411-422.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 9
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • Petrylak DP, Tangen CM, Hussain MH, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med. 2004;351: 1513-1520.
    • (2004) N Engl J Med. , vol.351 , pp. 1513-1520
    • Petrylak, D.P.1    Tangen, C.M.2    Hussain, M.H.3
  • 10
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med. 2004;351:1502-1512.
    • (2004) N Engl J Med. , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    De Wit, R.2    Berry, W.R.3
  • 11
    • 79957443342 scopus 로고    scopus 로고
    • Abiraterone and increased survival in metastatic prostate cancer
    • de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 2011;364:1995-2005.
    • (2011) N Engl J Med. , vol.364 , pp. 1995-2005
    • De Wit, J.S.1    Logothetis, C.J.2    Molina, A.3
  • 12
    • 77957682309 scopus 로고    scopus 로고
    • Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomized open-label trial
    • de Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomized open-label trial. Lancet. 2010;376:1147-1154.
    • (2010) Lancet , vol.376 , pp. 1147-1154
    • De Bono, J.S.1    Oudard, S.2    Ozguroglu, M.3
  • 13
    • 0037009822 scopus 로고    scopus 로고
    • A randomized, placebocontrolled trial of zoledronic acid in patients with hormonerefractory metastatic prostate carcinoma
    • Saad F, Gleason DM, Murray R, et al. A randomized, placebocontrolled trial of zoledronic acid in patients with hormonerefractory metastatic prostate carcinoma. J Natl Cancer Inst. 2002;94:1458-1468.
    • (2002) J Natl Cancer Inst. , vol.94 , pp. 1458-1468
    • Saad, F.1    Gleason, D.M.2    Murray, R.3
  • 14
    • 69049105440 scopus 로고    scopus 로고
    • Denosumab in men receiving androgen-deprivation therapy for prostate cancer
    • Smith MR, Egerdie B, Hernández Toriz N, et al. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med. 2009;361:745-755.
    • (2009) N Engl J Med. , vol.361 , pp. 745-755
    • Smith, M.R.1    Egerdie, B.2    Hernández, T.N.3
  • 15
    • 79952360832 scopus 로고    scopus 로고
    • Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, doubleblind study
    • Fizazi K, Carducci M, Smith M, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, doubleblind study. Lancet. 2011;377:813-822.
    • (2011) Lancet , vol.377 , pp. 813-822
    • Fizazi, K.1    Carducci, M.2    Smith, M.3
  • 16
    • 77952105685 scopus 로고    scopus 로고
    • Antitumour activity of MDV3100 in castration-resistant prostate cancer: A phase 1-2 study
    • Scher HI, Beer TM, Higano CS, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: A phase 1-2 study. Lancet. 2010;375:1437-1446.
    • (2010) Lancet , vol.375 , pp. 1437-1446
    • Scher, H.I.1    Beer, T.M.2    Higano, C.S.3
  • 17
    • 78049477140 scopus 로고    scopus 로고
    • Lenalidomide in nonmetastatic biochemically relapsed prostate cancer: Results of a phase I/II double-blinded, randomized study
    • Keizman D, Zahurak M, Sinibaldi V, et al. Lenalidomide in nonmetastatic biochemically relapsed prostate cancer: results of a phase I/II double-blinded, randomized study. Clin Cancer Res. 2010;16:5269-5276.
    • (2010) Clin Cancer Res. , vol.16 , pp. 5269-5276
    • Keizman, D.1    Zahurak, M.2    Sinibaldi, V.3
  • 18
    • 77955714649 scopus 로고    scopus 로고
    • A randomized, doubleblind, placebo-controlled phase III trial comparing docetaxel, prednisone, and placebo with docetaxel, prednisone, and bevacizumab in men with metastatic castration-resistant prostate cancer (mCRPC): Survival results of CALGB 90401
    • LBA4511
    • Kelly WK, Halabi S, Carducci MA, et al. A randomized, doubleblind, placebo-controlled phase III trial comparing docetaxel, prednisone, and placebo with docetaxel, prednisone, and bevacizumab in men with metastatic castration-resistant prostate cancer (mCRPC): Survival results of CALGB 90401. J Clin Oncol. 2010;28:18s. (suppl; abstrLBA4511).
    • (2010) J Clin Oncol. , vol.28 , pp. 18s
    • Kelly, W.K.1    Halabi, S.2    Carducci, M.A.3
  • 19
    • 77955710046 scopus 로고    scopus 로고
    • A randomized, multicenter, international phase II study of tasquinimod in chemotherapy naive patients with metastatic castrate resistant prostate cancer (CRPC)
    • 4510
    • Pili R, Haggman M, Stadler WM, et al. A randomized, multicenter, international phase II study of tasquinimod in chemotherapy naive patients with metastatic castrate resistant prostate cancer (CRPC) (abstract #4510). J Clin Oncol. 2010;28:344s.
    • (2010) J Clin Oncol. , vol.28 , pp. 344s
    • Pili, R.1    Haggman, M.2    Stadler, W.M.3
  • 20
    • 33750728404 scopus 로고    scopus 로고
    • Targeting bone metastasis in prostate cancer with endothelin receptor antagonists
    • Review
    • Carducci MA, Jimeno A. Targeting bone metastasis in prostate cancer with endothelin receptor antagonists. Clin Cancer Res. 2006;12:6296s-6300s. Review.
    • (2006) Clin Cancer Res. , vol.12 , pp. 6296s-6300s
    • Carducci, M.A.1    Jimeno, A.2
  • 21
    • 35648968713 scopus 로고    scopus 로고
    • A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
    • Carducci MA, Saad F, Abrahamsson PA, et al. A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. Cancer. 2007;110:1959-1966.
    • (2007) Cancer , vol.110 , pp. 1959-1966
    • Carducci, M.A.1    Saad, F.2    Abrahamsson, P.A.3
  • 22
    • 55549112219 scopus 로고    scopus 로고
    • Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer
    • Nelson JB, Love W, Chin JL, et al. Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer. Cancer. 2008;113:2478-2487.
    • (2008) Cancer , vol.113 , pp. 2478-2487
    • Nelson, J.B.1    Love, W.2    Chin, J.L.3
  • 23
    • 77956634017 scopus 로고    scopus 로고
    • Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castrationresistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: A double-blind, placebocontrolled, randomized Phase II trial
    • James ND, Caty A, Payne H, et al. Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: A double-blind, placebocontrolled, randomized Phase II trial. BJU Int. 2010;106:966-973.
    • (2010) BJU Int. , vol.106 , pp. 966-973
    • James, N.D.1    Caty, A.2    Payne, H.3
  • 24
    • 79955835748 scopus 로고    scopus 로고
    • Phase III study of the efficacy and safety of zibotentan (ZD4054) in patients with bone metastatic castration-resistant prostate cancer (CRPC)
    • ASCO, Genitourinary cancer symposium, 2011 117
    • Nelson JB, Fizazi K, Miller K, et al. Phase III study of the efficacy and safety of zibotentan (ZD4054) in patients with bone metastatic castration-resistant prostate cancer (CRPC). J Clin Oncol. 2011; 29(suppl 7): Abstract117 (ASCO, Genitourinary cancer symposium, 2011).
    • (2011) J Clin Oncol , vol.29
    • Nelson, J.B.1    Fizazi, K.2    Miller, K.3
  • 25
    • 41949104346 scopus 로고    scopus 로고
    • Design and endpoints of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: Recommendations of the prostate cancer clinical trials working group
    • Scher HI, Halabi S, Tannock I, et al. Design and endpoints of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol. 2008;26:1148-1159.
    • (2008) J Clin Oncol , vol.26 , pp. 1148-1159
    • Scher, H.I.1    Halabi, S.2    Tannock, I.3
  • 26
    • 77951474381 scopus 로고    scopus 로고
    • Src kinase inhibitors: An emerging therapeutic treatment option for prostate cancer
    • Edwards J. Src kinase inhibitors: An emerging therapeutic treatment option for prostate cancer. Expert Opin Investig Drugs. 2010;19:605-614.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 605-614
    • Edwards, J.1
  • 27
    • 36248973171 scopus 로고    scopus 로고
    • The role of Src in prostate cancer
    • Fizazi K. The role of Src in prostate cancer. Ann Oncol. 2007; 18:1765-1773.
    • (2007) Ann Oncol , vol.18 , pp. 1765-1773
    • Fizazi, K.1
  • 28
    • 73149115110 scopus 로고    scopus 로고
    • Phase II study of dasatinib in patients with metastatic castration-resistant prostate cancer
    • Yu EY, Wilding G, Posadas E, et al. Phase II study of dasatinib in patients with metastatic castration-resistant prostate cancer. Clin Cancer Res. 2009;15:7421-7428.
    • (2009) Clin Cancer Res. , vol.15 , pp. 7421-7428
    • Yu, E.Y.1    Wilding, G.2    Posadas, E.3
  • 29
    • 79955610443 scopus 로고    scopus 로고
    • Once daily dasatinib: Expansion of a phase 2 study evaluating the safety and efficacy of dastanib in patients with metastatic castration resistant prostate cancer
    • Yu EY, Massard C, Gross ME, et al. Once daily dasatinib: expansion of a phase 2 study evaluating the safety and efficacy of dastanib in patients with metastatic castration resistant prostate cancer. Urology. 2011;77:1166-1171.
    • (2011) Urology , vol.77 , pp. 1166-1171
    • Yu, E.Y.1    Massard, C.2    Gross, M.E.3
  • 30
    • 70249151654 scopus 로고    scopus 로고
    • Dasatinib and docetaxel combination treatment for patients with castration resistant progressive prostate cancer: A phase 1/2 study (CA180-086)
    • Araujo J, Gallick G, Trudel G, et al. Dasatinib and docetaxel combination treatment for patients with castration resistant progressive prostate cancer: A phase 1/2 study (CA180-086). J Clin Oncol. 2009;27:15s. (abstract5061).
    • (2009) J Clin Oncol. , vol.27 , pp. 15s
    • Araujo, J.1    Gallick, G.2    Trudel, G.3
  • 31
    • 61749096864 scopus 로고    scopus 로고
    • A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: A California Cancer Consortium study
    • Lara PN Jr, Longmate J, Evans CP, et al. A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: A California Cancer Consortium study. Anticancer Drugs. 2009;20:179-184.
    • (2009) Anticancer Drugs , vol.20 , pp. 179-184
    • Lara, P.N.1    Longmate, J.2    Evans, C.P.3
  • 32
    • 80053571555 scopus 로고    scopus 로고
    • Cabozantinib (XL184) in metastatic castration-resistant prostate cancer: Results from a phase II randomized discontinuation trial
    • 4516
    • Hussain M, Smith MR, Sweeney C, et al. Cabozantinib (XL184) in metastatic castration-resistant prostate cancer: Results from a phase II randomized discontinuation trial (abstract #4516). J Clin Oncol. 2011;29:293s.
    • (2011) J Clin Oncol. , vol.29 , pp. 293s
    • Hussain, M.1    Smith, M.R.2    Sweeney, C.3
  • 33
    • 0027252452 scopus 로고
    • Results of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer
    • Porter AT, McEwan AJ, Powe JE, et al. Results of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer. Int J Radiat Oncol Biol Phys. 1993;25:805-813.
    • (1993) Int J Radiat Oncol Biol Phys. , vol.25 , pp. 805-813
    • Porter, A.T.1    McEwan, A.J.2    Powe, J.E.3
  • 34
    • 2342509633 scopus 로고    scopus 로고
    • Samarium-153-lexidronam complex for treatment of painful bone metastases in hormone-refractory prostate cancer
    • Sartor O, Reid RH, Hoskin PJ, et al. Samarium-153-Lexidronam complex for treatment of painful bone metastases in hormone-refractory prostate cancer. Urology. 2004;63: 940-945.
    • (2004) Urology , vol.63 , pp. 940-945
    • Sartor, O.1    Reid, R.H.2    Hoskin, P.J.3
  • 35
    • 20644447798 scopus 로고    scopus 로고
    • First clinical experience with A-emitting Radium-223 in the treatment of skeletal metastases
    • Nilsson S, Larsen RH, Fossa SD, et al. First clinical experience with A-emitting Radium-223 in the treatment of skeletal metastases. Clin Cancer Res. 2005;11:4451-4459.
    • (2005) Clin Cancer Res , vol.11 , pp. 4451-4459
    • Nilsson, S.1    Larsen, R.H.2    Fossa, S.D.3
  • 36
    • 33750701925 scopus 로고    scopus 로고
    • Bone-seeking radium-223 adjuvant to external beam radiotherapy demonstrates significant decline in bone-alkaline phosphatase and PSA in patients with hormone refractory prostate cancer
    • 215
    • Nilsson S, Franzen L, Tyrrell C, et al. Bone-seeking radium-223 adjuvant to external beam radiotherapy demonstrates significant decline in bone-alkaline phosphatase and PSA in patients with hormone refractory prostate cancer. ASCO Prostate Cancer Symposium. 2006. (abstract 215).
    • (2006) ASCO Prostate Cancer Symposium
    • Nilsson, S.1    Franzen, L.2    Tyrrell, C.3
  • 37
    • 80053571997 scopus 로고    scopus 로고
    • Alkaline phosphatase (ALP) normalization and overall survival in patients with bone metastasis from castration-resistant prostate cancer (CRPC) treated with radium-223
    • abstract
    • Parker C, O'Bryan-Tear CG, Bolstad B, et al. Alkaline phosphatase (ALP) normalization and overall survival in patients with bone metastasis from castration-resistant prostate cancer (CRPC) treated with radium-223. ASCO Genitourinary Cancer Symposium. 2011;29(suppl 15):4620(abstract).
    • (2011) ASCO Genitourinary Cancer Symposium , vol.29 , pp. 4620
    • Parker, C.1    O'Bryan-Tear, C.G.2    Bolstad, B.3
  • 38
    • 84856406453 scopus 로고    scopus 로고
    • Overall survival benefit of radium-223 chloride (Alpharadin) in the treatment of patients with symptomatic bone metastases in castration-resistant prostate cancer: A phase III randomized trial (ALSYMPCA)
    • 1LBA
    • Parker C, Heinrich D, O'Sullivan JM, et al. Overall survival benefit of radium-223 chloride (Alpharadin) in the treatment of patients with symptomatic bone metastases in castration-resistant prostate cancer: A phase III randomized trial (ALSYMPCA). Eur J Cancer. 2011;47(suppl 2):3, (Abstract1LBA).
    • (2011) Eur J Cancer , vol.47 , pp. 3
    • Parker, C.1    Heinrich, D.2    O'Sullivan, J.M.3
  • 39
    • 70349241644 scopus 로고    scopus 로고
    • Bone marrow derived cathepsin K cleaves SPARC in bone metastasis
    • Podgorski I, Linebaugh BE, Koblinski JE, et al. Bone marrow derived cathepsin K cleaves SPARC in bone metastasis. Am J Pathol. 2009;175:1255-1269.
    • (2009) Am J Pathol , vol.175 , pp. 1255-1269
    • Podgorski, I.1    Linebaugh, B.E.2    Koblinski, J.E.3
  • 40
    • 79952278967 scopus 로고    scopus 로고
    • The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: Results of a 4-week, double-blind, randomized, controlled trial
    • Jensen AB, Wynne C, Ramirez G, et al. The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: results of a 4-week, double-blind, randomized, controlled trial. Clin Breast Cancer. 2010;10:452-458.
    • (2010) Clin Breast Cancer , vol.10 , pp. 452-458
    • Jensen, A.B.1    Wynne, C.2    Ramirez, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.