Pharmacotherapy of generalized anxiety disorder

Modern Trends in Pharmacopsychiatry

Volumn 29, Issue , 2013, Pages 119-127

  Allgulander, Christer ^a,d   Baldwin, David S ^b,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE; PREGABALIN; QUETIAPINE; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; ANGIOGENESIS INHIBITOR;

ANXIETY; ANXIETY DISORDER; ARTICLE; COGNITIVE THERAPY; COST OF ILLNESS; EPILEPSY; EVIDENCE BASED MEDICINE; GENERALIZED ANXIETY DISORDER; HUMAN; INSOMNIA; PARKINSON DISEASE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; ANIMAL; DRUG THERAPY; METHODOLOGY; REVIEW;

ANGIOGENESIS INHIBITORS; ANIMALS; ANXIETY DISORDERS; DRUG THERAPY; HUMANS;

EID: 84908025902     PISSN: 16622685     EISSN: 16624505     Source Type: Book Series    
DOI: 10.1159/000351955     Document Type: Article

References (58)

1. Nitschke JB, Sarinopoulos I, Oathes DJ, Johnstone T, Whalen PJ, Davidson RJ, Kalin NH: Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am J Psychiatry 2009; 166: 302-310
2. Etkin A, Prater KE, Hoeft F, Menon V, Schatzberg AF: Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder. Am J Psychiatry 2010; 167: 545-554
3. Brambilla P, Como G, Isola M, Taboga F, Zuliani R, Goljevscek S, Ragogna M, et al: White-matter abnormalities in the right posterior hemisphere in generalized anxiety disorder: A diffusion imaging study. Psychol Med 2011, DOI:10.1017/S0033291711001255
4. Roth WT, Doberenz S, Dietel A, Conrad A, Mueller A, Wollburg E, Meuret AE, Taylor CB, Kim S: Sympathetic activation in broadly defined generalized anxiety disorder. J Psychiatry Res 2008; 42: 205-212
5. Seddon K, Morris K, Bailey J, Potokar J, Rich A, Wilson S, Bettica P, Nutt DJ: Effects of 7.5% CO 2 challenge in generalized anxiety disorder. J Psychopharmacol 2011; 25: 43-51
6. Bailey JE, Dawson GR, Dourish CT, Nutt DJ: Validating the inhalation of 7.5% CO 2 in healthy volunteers as a human experimental medicine: A model of generalized anxiety disorder (GAD). J Psychopharmacol 2011; 25: 1192-1198
7. Borkovec TD, Roemer L: Perceived functions of worry among generalized anxiety disorder subjects: distraction from more emotionally distressing topics? J Behav Ther Exp Psychiatry 1995; 26: 25-30
8. Ladouceur R, Gosselin P, Dugas MJ: Experimental manipulation of intolerance of uncertainty: A study of a theoretical model of worry. Behav Res Ther 2000; 38: 933-941
9. MacLeod C, Rutherford E: Information-processing approaches. Assessing the selective, functioning of attention, interpretation, and retrieval; in Heimberg RG, Turk CL, Mennin DS (eds): Generalized Anxiety Disorder. Advances in Research and Practice. New York, Guilford Press, 2004, pp 109-142
10. Heimberg RG, Turk CL, Mennin DS (eds): Generalized Anxiety Disorder. Advances in Research and Practice. New York, Guilford Press, 2004
11. Hale WW, Klimstra TA, Meeus WHJ: Is the generalized anxiety disorder symptom of worry just another form of neuroticism? A 5-year longitudinal study of adolescents from the general population J Clin Psychiatry 2010; 71: 942-948
12. Mackintosh MA, Gatz M, Wetherell JL, Pedersen NL: A twin study of lifetime generalized anxiety disorder (GAD) in older adults: genetic and environmental influences shared by neuroticism and GAD. Twin Res Hum Genet 2006; 9: 30-37
13. Bebbington PE, Brugha TS, Meltzer H, Jenkins R, Ceresa C, Farrell M, Lewis G: Neurotic disorders and the receipt of psychiatric treatment. Psychol Med 2000; 30: 1369-1376
14. Ansseau M, Fischler B, Dierick M, Mignon A, Leyman S: Prevalence and impact of generalized anxiety disorder and major depression in primary care in Belgium and Luxemburg: the GADIS study. Eur Psychiatry 2005; 20: 229-235
15. Moffitt TE, Harrington H, Caspi A, Kim-Cohen J, Goldberg D, Gregory AM, Poulton R: Depression and generalized anxiety disorder: cumulative and sequential comorbidity in a birth cohort followed prospectively to age 32 years. Arch Gen Psychiatry 2007; 64: 651-660
16. Weiller E, Bisserbe JC, Maier W, Lecrubier Y: Prevalence and recognition of anxiety syndromes in five European primary care settings. A report from the WHO study on Psychological Problems in General Health Care. Br J Psychiatry Suppl 1998; 34: 18-23
17. Fernández A, Rubio-Valera M, Bellón JA, et al: Recognition of anxiety disorders by the general practitioner: results from the DASMAP Study. Gen Hosp Psychiatry 2012; 34: 227-233
18. Munk-Jörgensen P, Allgulander C, Dahl AA, Foldager L, Holm M, Rasmussen I, Virta A, Huuhtanen M-J, Wittchen H-U: Prevalence of generalized anxiety disorder in general practice in Denmark, Finland, Norway, and Sweden. Psychiatr Serv 2006; 57: 1738-1744
19. Hinton DE, Park L, Hsia C, Hofmann S, Pollack MH: Anxiety disorder presentations in Asian populations: A review. CNS Neurosci Ther 2009; 15: 295-303
20. Marques L, Robinaugh DJ, LeBlanc NJ, Hinton D: Cross-cultural variations in the prevalence and presentation of anxiety disorders. Expert Rev Neurother 2011; 11: 313-322
21. Chen P-Y, Wang S-C, Poland RE, Lin K-M: Biological variations in depression and anxiety between East and West. CNS Neurosci Therap 2009; 15: 283-294
22. Perlis RH, Fijal B, Dharia S, Houston JP: Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder. Pharmacogenomics J 2013; 13: 280-285
23. Allgulander C: Morbid anxiety as a risk factor in patients with somatic diseases: A review of recent findings. J Psychiatry 2010; 1: 11-19
24. Shiba M, Bower JH, Maraganore DM, McDonnell SK, Peterson BJ, Ahlskog JE, Schaid DJ, Rocca WA: Anxiety disorders and depressive disorders preceding Parkinson's disease: A case-control study. Mov Disord 2000; 15: 669-677
25. Johnson EK, Jones JE, Sidenberg M, Hermann BP: The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life, in epilepsy. Epilepsia 2004; 45: 544-550
26. Engum A: The role of depression and anxiety in onset of diabetes in a large population-based study. J Psychosom Res 2007; 62: 31-38
27. Martens EJ, de Jonge P, Na B, Cohen BE, Lett H, Whooley MA: Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease. Arch Gen Psychiatry 2010; 67: 750-758
28. Huang KL, Su TP, Chen TJ, Chou YH, Bai YM: Comorbidity of cardiovascular diseases with mood and anxiety disorder: A population based 4-year study. Psychiatry Clin Neurosci 2009; 63: 401-409
29. Chen Y-H, Tsai S-Y, Lee H-C, Lin H-C: Increased risk of acute myocardial infarction for patients with panic disorder: A nationwide population study. Psychosom Med 2009; 71: 798-804
30. Elman I, Zubieta J-K, Borsook D: The missing P in psychiatric training. Arch Gen Psychiatry 2011; 68: 12-20
31. Beesdo K, Hoyer J, Jacobi F, Low NC, Höfler M, Wittche HU: Association between generalized anxiety levels and pain in a community sample: evidence for diagnostic specificity. J Anxiety Disord 2009; 23: 684-693
32. Romera I, Férnandez-Pérez S, Montego AL, Caballero F, Caballero L, Arbesú JA, Delgado-Cohen H, et al: Generalized anxiety disorder, with or without comorbid major depressive disorder, in primary care: prevalence of painful somatic symptoms, functioning and health status. J Affect Disord 2010; 127: 160-168
33. Raphale KG, Janal MN, Nayak S, Schwartz JE, Gallagher M: Psychiatric comorbidities in a community sample of women with fibromyalgia. Pain 2006; 124: 117-125
34. Benjamin S, Herr NR, McDuffie J, Nagi A, Williams JW: Performance characteristics of self-report instruments for diagnosing generalized anxiety and panic disorders in primary care: A systematic review. VA Evidence-Based Synthesis Program Reports. Washington, Department of Veterans Affairs, August 2011
35. Monti JM, Monti D: Sleep disturbance in generalized anxiety disorder and its treatment. Sleep Med Rev 2000; 4: 263-276
36. Sandelin R, Kowalski J, Ahnemark E, Allgulander C: Generalized anxiety disorder treatments in a cohort of all 3,701 cases in psychiatric care in 2006, Sweden. Eur Psychiatry 2012;28:125-133
37. Marcks BA, Weisberg RB, Edelen MO, Keller MB: The relationship between sleep disturbance and the course of anxiety disorders in primary care patients. Psychiatry Res 2010; 178: 487-492
38. Pollack M, Kinrys G, Krystal A, McCall WV, Roth T, Schaefer K, Rubens R, et al: Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder. Arch Gen Psychiatry 2008; 65: 551-562
39. Andlin-Sobocki P, Wittchen HU: Cost of anxiety disorders in Europe. Eur J Neurol 2005; 12: 39-44
40. Revicki DA, Travers K, Wyrwich KW, Svedsäter H, Locklear J, Mattera MS, Sheehan DV, Montgomery S: Humanistic and economic burden of generalized anxiety disorder in North America and Europe. J Affect Disord 2012; 140: 103-112
41. Bandelow B, Zohar J, Hollander E, Kasper S, Möller HJ, WFSBP Task Force on Treatment Guidelines for Anxiety Obsessive-Compulsive Post-Traumatic Stress Disorders: World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders-1st revision. World J Biol Psychiatry 2008; 9: 248-312
42. Hoyer J, Gloster AT: Psychotherapy for generalized anxiety disorder: don't worry, it works! Psychiatr Clin North Am 2009; 32: 629-640
43. Leichsenring F, Salzer S, Jaeger U, Kachele H, Kreische R, Leweke F, Rüger U, Winkelbach C, Leibing E: Short-term psychodynamic psychotherapy and cognitive-behavioral therapy in generalized anxiety disorder: A randomized, controlled trial. Am J Psychiatry 2009; 166: 875-881
44. Robinson E, Titov N, Andrews G, McIntyre K, Schwencke G, Solley K: Internet treatment for generalized anxiety disorder: A randomized controlled trial comparing clinician vs. technician assistance. PLoS One 2010; 5:e10942
45. Crits-Christoph P, Newman MG, Rickels K, Gallop R, Connolly Gibbons MB, Hamilton JL, Ring-Kurtz S, Pastva AM: Combined medication and cognitive therapy for generalized anxiety disorder. J Anxiety Disord 2011; 25: 1087-1094
46. van der Heiden C, Muris P, van der Molen HT: Randomized controlled trial on the effectiveness of metacognitive therapy and intolerance-of-uncertainty therapy for generalized anxiety disorder. Behav Res Ther 2012; 50: 100-109
47. Rickels K, Etemad B, Khalid-Khan S, Lohoff FW, Rynn MA, Gallop RJ: Time to relapse after 6 and
48. months' treatment of generalized anxiety disorder with venlafaxine extended release. Arch Gen Psychiatry 2010; 67: 1274-1281
49. Reinhold JA, Mandos LA, Rickels K, Lohoff FW: Pharmacological treatment of generalized anxiety disorder. Expert Opin Pharmacother 2011; 12: 2457-2467
50. Wu W, Wang G, Ball SG, Desaiah D, Ang Q: Duloxetine versus placebo in the treatment of patients with generalized anxiety disorder in China. Chin Med J 2011; 124: 3260-3268
51. Ross LE, McLean LM: Anxiety disorders during pregnancy and the postpartum period: A systematic review. J Clin Psychiatry 2006; 67: 1285-1298
52. Stein A, Craske MG, Lehtonen A, Harvey A, et al: Maternal cognitions and mother-infant interaction in postnatal depression and generalized anxiety disorder. J Abnorm Psychol 2012; 121: 795-809
53. Stein DJ, Bandelow B, Merideth C, Olausson B, Szamosi J, Eriksson H: Efficacy and tolerability of extended release quetiapine fumarate (quetiapine XR) monotherapy in patients with generalised anxiety disorder: An analysis of pooled data from three 8-week placebo-controlled studies. Hum Psychopharmacol 2011; 26: 616-628
54. Rickels K, Shiovitz TM, Ramey TS, Weaver JJ, Knapp LE, Miceli JJ: Adjunctive therapy with pregabalin in generalized anxiety disorder patients with partial response to SSRI or SNRI treatment. Int Clin Psychopharmacol 2012; 27: 142-150
55. Pollack MH: Refractory generalized anxiety disorder. J Clin Psychiatry 2009; 70(suppl 2):32-38
56. Baldwin DS, Allgulander C, Bandelow B, Ferre F, Pallanti S: An international survey of reported prescribing practice in the treatment of patients with generalised anxiety disorder. World J Biol Psychiatry November 2012; 13: 510-516
57. Porensky EK, Dew MA, Karp JF, Skidmore E, Rollman BL, Shear MK, Lenze EJ: The burden of late-life generalized anxiety disorder: effects on disability, health-related quality of life, and healthcare utilization. Am J Geriatr Psychiatry 2009; 17: 473-482
58. Smoller JW, Block SR, Young MM: Genetics of anxiety disorders: the complex road from DSM to DNA. Depress Anxiety 2009; 26: 965-975.