Calcium supplementation increases blood creatinine concentration in a randomized controlled trial

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Barry, Elizabeth L ^a   Mott, Leila A ^a   Melamed, Michal L ^b   Rees, Judith R ^a   Ivanova, Anastasia ^c   Sandler, Robert S ^d   Ahnen, Dennis J ^e   Bresalier, Robert S ^f   Summers, Robert W ^g   Bostick, Roberd M ^h   Baron, John A ^a,d  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c University of North Carolina at Chapel Hill   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF COLORADO   (United States)

^f UNIVERSITY OF TEXAS   (United States)

^g UNIVERSITY OF IOWA   (United States)

^h EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CARBONATE; COLECALCIFEROL; PLACEBO; CALCIUM INTAKE; CREATININE;

ADULT; AGED; ARTICLE; CANCER PREVENTION; CANCER RECURRENCE; CLINICAL EFFECTIVENESS; COLORECTAL ADENOMA; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIET SUPPLEMENTATION; DRUG EFFECT; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MULTICENTER STUDY (TOPIC); OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; ADMINISTRATION AND DOSAGE; BLOOD; CALCIUM INTAKE; DIET THERAPY; KIDNEY FUNCTION TEST; MIDDLE AGED; OSTEOPOROSIS; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; CALCIUM, DIETARY; CHOLECALCIFEROL; CREATININE; DIETARY SUPPLEMENTS; FEMALE; HUMANS; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; OSTEOPOROSIS;

EID: 84908017852     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108094     Document Type: Article

References (54)

1. Dawson-Hughes B (2008) A Revised Clinician's Guide to the Prevention and Treatment of Osteoporosis. J Clin Endocrinol Metab. 93:2463-2465.
2. Bailey RL, Dodd KW, Goldman JA, Gahche JJ, Dwyer JT, et al. (2010) Estimation of Total Usual Calcium and Vitamin D Intakes in the United States. J Nutr. 140:817-822.
3. Mangano KM, Walsh SJ, Insogna KL, Kenny AM, Kerstetter JE (2011) Calcium Intake in the United States from Dietary and Supplemental Sources across Adult Age Groups: New Estimates from the National Health and Nutrition Examination Survey 2003-2006. J Am Diet Assoc. 111:687-695.
4. Gahche J, Bailey R, Burt V, Hughes J, Yetley E, et al. (2011) Dietary Supplement Use among U. S. Adults Has Increased since Nhanes Iii (1988-1994). NCHS Data Brief: 1-8.
5. Baron JA, Beach M, Mandel JS, van Stolk RU, Haile RW, et al. (1999) Calcium Supplements for the Prevention of Colorectal Adenomas. Calcium Polyp Prevention Study Group. N Engl J Med. 340:101-107.
6. Cho E, Smith-Warner SA, Spiegelman D, Beeson WL, van den Brandt PA, et al. (2004) Dairy Foods, Calcium, and Colorectal Cancer: A Pooled Analysis of 10 Cohort Studies. J Natl Cancer Inst. 96:1015-1022.
7. Shaukat A, Scouras N, Schunemann HJ (2005) Role of Supplemental Calcium in the Recurrence of Colorectal Adenomas: A Metaanalysis of Randomized Controlled Trials. Am J Gastroenterol. 100:390-394.
8. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, et al. (2011) The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know. J Clin Endocrinol Metab. 96:53-58.
9. Bolland MJ, Barber PA, Doughty RN, Mason B, Horne A, et al. (2008) Vascular Events in Healthy Older Women Receiving Calcium Supplementation: Randomised Controlled Trial. BMJ. 336:262-266.
10. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, et al. (2010) Effect of Calcium Supplements on Risk of Myocardial Infarction and Cardiovascular Events: Meta-Analysis. BMJ. 341:c3691.
11. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR (2011) Calcium Supplements with or without Vitamin D and Risk of Cardiovascular Events: Reanalysis of the Women's Health Initiative Limited Access Dataset and Meta-Analysis. BMJ. 342:d2040.
12. Xiao Q, Murphy RA, Houston DK, Harris TB, Chow WH, et al. (2013) Dietary and Supplemental Calcium Intake and Cardiovascular Disease Mortality: The National Institutes of Health-Aarp Diet and Health Study. JAMA Intern Med. 173:639-646.
13. Lewis JR, Calver J, Zhu K, Flicker L, Prince RL (2011) Calcium Supplementation and the Risks of Atherosclerotic Vascular Disease in Older Women: Results of a 5-Year Rct and a 4.5-Year Follow-Up. J Bone Miner Res. 26:35-41.
14. Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR, Jr. (2011) Dietary Supplements and Mortality Rate in Older Women: The Iowa Women's Health Study. Arch Intern Med. 171:1625-1633.
15. Rejnmark L, Avenell A, Masud T, Anderson F, Meyer HE, et al. (2012) Vitamin D with Calcium Reduces Mortality: Patient Level Pooled Analysis of 70, 528 Patients from Eight Major Vitamin D Trials. J Clin Endocrinol Metab. 97:2670-2681.
16. Wallace RB, Wactawski-Wende J, O'Sullivan MJ, Larson JC, Cochrane B, et al. (2011) Urinary Tract Stone Occurrence in the Women's Health Initiative (Whi) Randomized Clinical Trial of Calcium and Vitamin D Supplements. Am J Clin Nutr. 94:270-277.
17. Patel AM, Adeseun GA, Goldfarb S (2013) Calcium-Alkali Syndrome in the Modern Era. Nutrients. 5:4880-4893.
18. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, 3rd, et al. (2009) A New Equation to Estimate Glomerular Filtration Rate. Ann Intern Med. 150:604-612.
19. Smith EL, Gilligan C, Smith PE, Sempos CT (1989) Calcium Supplementation and Bone Loss in Middle-Aged Women. Am J Clin Nutr. 50:833-842.
20. Dawson-Hughes B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, et al. (1990) A Controlled Trial of the Effect of Calcium Supplementation on Bone Density in Postmenopausal Women. N Engl J Med. 323:878-883.
21. Reid IR, Ames RW, Evans MC, Gamble GD, Sharpe SJ (1993) Effect of Calcium Supplementation on Bone Loss in Postmenopausal Women. N Engl J Med. 328:460-464.
22. Recker RR, Hinders S, Davies KM, Heaney RP, Stegman MR, et al. (1996) Correcting Calcium Nutritional Deficiency Prevents Spine Fractures in Elderly Women. J Bone Miner Res. 11:1961-1966.
23. Riggs BL, O'Fallon WM, Muhs J, O'Connor MK, Kumar R, et al. (1998) Long-Term Effects of Calcium Supplementation on Serum Parathyroid Hormone Level, Bone Turnover, and Bone Loss in Elderly Women. J Bone Miner Res. 13:168-174.
24. Grant AM, Avenell A, Campbell MK, McDonald AM, MacLennan GS, et al. (2005) Oral Vitamin D3 and Calcium for Secondary Prevention of Low-Trauma Fractures in Elderly People (Randomised Evaluation of Calcium or Vitamin D, Record): A Randomised Placebo-Controlled Trial. Lancet. 365:1621-1628.
25. Prince RL, Devine A, Dhaliwal SS, Dick IM (2006) Effects of Calcium Supplementation on Clinical Fracture and Bone Structure: Results of a 5-Year, Double-Blind, Placebo-Controlled Trial in Elderly Women. Arch Intern Med. 166:869-875.
26. Reid IR, Mason B, Horne A, Ames R, Reid HE, et al. (2006) Randomized Controlled Trial of Calcium in Healthy Older Women. Am J Med. 119:777-785.
27. Bonnick S, Broy S, Kaiser F, Teutsch C, Rosenberg E, et al. (2007) Treatment with Alendronate Plus Calcium, Alendronate Alone, or Calcium Alone for Postmenopausal Low Bone Mineral Density. Curr Med Res Opin. 23:1341-1349.
28. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP (2007) Vitamin D and Calcium Supplementation Reduces Cancer Risk: Results of a Randomized Trial. Am J Clin Nutr. 85:1586-1591.
29. Reid IR, Bolland MJ, Grey A (2008) Effect of Calcium Supplementation on Hip Fractures. Osteoporos Int. 19:1119-1123.
30. Hofstad B, Vatn MH, Andersen SN, Owen RW, Larsen S, et al. (1998) The Relationship between Faecal Bile Acid Profile with or without Supplementation with Calcium and Antioxidants on Recurrence and Growth of Colorectal Polyps. Eur J Cancer Prev. 7:287-294.
31. Bonithon-Kopp C, Kronborg O, Giacosa A, Rath U, Faivre J (2000) Calcium and Fibre Supplementation in Prevention of Colorectal Adenoma Recurrence: A Randomised Intervention Trial. European Cancer Prevention Organisation Study Group. Lancet. 356:1300-1306.
32. Wactawski-Wende J, Kotchen JM, Anderson GL, Assaf AR, Brunner RL, et al. (2006) Calcium Plus Vitamin D Supplementation and the Risk of Colorectal Cancer. N Engl J Med. 354:684-696.
33. Peacock M, Liu G, Carey M, McClintock R, Ambrosius W, et al. (2000) Effect of Calcium or 25oh Vitamin D3 Dietary Supplementation on Bone Loss at the Hip in Men and Women over the Age of 60. J Clin Endocrinol Metab. 85:3011-3019.
34. Elders PJ, Netelenbos JC, Lips P, van Ginkel FC, Khoe E, et al. (1991) Calcium Supplementation Reduces Vertebral Bone Loss in Perimenopausal Women: A Controlled Trial in 248 Women between 46 and 55 Years of Age. J Clin Endocrinol Metab. 73:533-540.
35. Dazai Y, Iwata T, Hiwada K (1993) Augmentation of the Renal Tubular Dopaminergic Activity by Oral Calcium Supplementation in Patients with Essential Hypertension. Am J Hypertens. 6:933-937.
36. Muntner P, Coresh J, Smith JC, Eckfeldt J, Klag MJ (2000) Plasma Lipids and Risk of Developing Renal Dysfunction: The Atherosclerosis Risk in Communities Study. Kidney International. 58:293-301.
37. Agarwal R, Hynson JE, Hecht TJ, Light RP, Sinha AD (2011) Short-Term Vitamin D Receptor Activation Increases Serum Creatinine Due to Increased Production with No Effect on the Glomerular Filtration Rate. Kidney international. 80:1073-1079.
38. Shlipak MG, Katz R, Kestenbaum B, Siscovick D, Fried L, et al. (2009) Rapid Decline of Kidney Function Increases Cardiovascular Risk in the Elderly. J Am Soc Nephrol. 20:2625-2630.
39. Rifkin DE, Shlipak MG, Katz R, Fried LF, Siscovick D, et al. (2008) Rapid Kidney Function Decline and Mortality Risk in Older Adults. Arch Intern Med. 168:2212-2218.
40. Holtkamp FA, de Zeeuw D, Thomas MC, Cooper ME, de Graeff PA, et al. (2011) An Acute Fall in Estimated Glomerular Filtration Rate During Treatment with Losartan Predicts a Slower Decrease in Long-Term Renal Function. Kidney International. 80:282-287.
41. Woo JJ (2007) Adverse Event Monitoring and Multivitamin-Multimineral Dietary Supplements. Am J Clin Nutr. 85:323S-324S.
42. Mulholland CA, Benford DJ (2007) What Is Known About the Safety of Multivitamin-Multimineral Supplements for the Generally Healthy Population? Theoretical Basis for Harm. Am J Clin Nutr. 85:318S-322S.
43. Ross AC, Taylor CL, Yaktine AL, Del Valle HB (2011) Dietary Reference Intakes for Calcium and Vitamin D. Washington DC: National Academies.
44. Moyer VA, U. S. Preventive Services Task Force (2013) Vitamin D and Calcium Supplementation to Prevent Fractures in Adults: U. S. Preventive Services Task Force Recommendation Statement. Ann Intern Med. 158:691-696.
45. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, et al. (2006) Calcium Plus Vitamin D Supplementation and the Risk of Fractures. N Engl J Med. 354:669-683.
46. Prentice RL, Pettinger MB, Jackson RD, Wactawski-Wende J, Lacroix AZ, et al. (2013) Health Risks and Benefits from Calcium and Vitamin D Supplementation: Women's Health Initiative Clinical Trial and Cohort Study. Osteoporos Int. 24:567-580.
47. Green JH, Booth C, Bunning R (2003) Postprandial Metabolic Responses to Milk Enriched with Milk Calcium Are Different from Responses to Milk Enriched with Calcium Carbonate. Asia Pac J Clin Nutr. 12:109-119.
48. Curhan GC, Willett WC, Knight EL, Stampfer MJ (2004) Dietary Factors and the Risk of Incident Kidney Stones in Younger Women: Nurses' Health Study Ii. Arch Intern Med. 164:885-891.
49. Favus MJ (2011) The Risk of Kidney Stone Formation: The Form of Calcium Matters. Am J Clin Nutr. 94:5-6.
50. Li K, Kaaks R, Linseisen J, Rohrmann S (2012) Associations of Dietary Calcium Intake and Calcium Supplementation with Myocardial Infarction and Stroke Risk and Overall Cardiovascular Mortality in the Heidelberg Cohort of the European Prospective Investigation into Cancer and Nutrition Study (Epic-Heidelberg). Heart. 98:920-925.
51. Boudville N, Kemp A, Moody H, Fassett RG, Pedagogos E, et al. (2012) Factors Associated with Chronic Kidney Disease Progression in Australian Nephrology Practices. Nephron Clin Pract. 121:c36-41.
52. Block GA, Wheeler DC, Persky MS, Kestenbaum B, Ketteler M, et al. (2012) Effects of Phosphate Binders in Moderate Ckd. J Am Soc Nephrol. 23:1407-1415.
53. James MT, Hemmelgarn BR, Tonelli M (2010) Early Recognition and Prevention of Chronic Kidney Disease. Lancet. 375:1296-1309.
54. Levey AS, Coresh J (2012) Chronic Kidney Disease. Lancet. 379:165-180.