Iron deficiency in a multi-ethnic Asian population with and without heart failure: Prevalence, clinical correlates, functional significance and prognosis

European Journal of Heart Failure

Volumn 16, Issue 10, 2014, Pages 1125-1132

  Yeo, Tee Joo ^a   Yeo, Poh Shuan Daniel ^b   Ching Chiew Wong, Raymond ^a   Ong, Hean Yee ^c   Leong, Kui Toh Gerard ^d   Jaufeerally, Fazlur ^e,f   Sim, David ^a   Santhanakrishnan, Rajalakshmi ^g,h   Lim, Shir Lynn ^a   Chan, Michelle M Y ^f,g   Chai, Ping ^a   Low, Adrian F ^a,h   Ling, Lieng H ^a,g,h   Ng, Tze Pin ^h   Richards, A Mark ^a,g,h   Lam, Carolyn S P ^a,g,h  

^a DEPARTMENT OF CARDIOLOGY   (Singapore)

^b GLENEAGLES HOSPITAL   (Singapore)

^c KHOO TECK PUAT HOSPITAL   (Singapore)

^d CHANGI GENERAL HOSPITAL   (Singapore)

^e SINGAPORE GENERAL HOSPITAL   (Singapore)

^f DUKE NUS MEDICAL SCHOOL   (Singapore)

^g Cardiovascular Research Center   (Singapore)

^h NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Exercise capacity; Heart failure; Iron deficiency

Indexed keywords

FERRITIN; IRON; TRANSFERRIN;

ADULT; ANEMIA; ARTICLE; BODY MASS; CARDIOPULMONARY EXERCISE TEST; CHINESE; COMMUNITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ETHNICITY; EVENT FREE SURVIVAL; FEMALE; FUNCTIONAL STATUS; HEART FAILURE; HEMATOLOGICAL PARAMETERS; HUMAN; INDIAN; IRON DEFICIENCY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PROGNOSIS; SEX DIFFERENCE; SOUTHEAST ASIAN; TRANSFERRIN SATURATION; AGED; BLOOD; COMORBIDITY; DIAGNOSIS; DISEASE FREE SURVIVAL; ETHNOLOGY; EXERCISE TEST; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; IRON DEFICIENCY ANEMIA; PATHOPHYSIOLOGY; PREVALENCE; SOUTHEAST ASIA;

AGED; ANEMIA, IRON-DEFICIENCY; ASIA, SOUTHEASTERN; COMORBIDITY; DISEASE-FREE SURVIVAL; EXERCISE TEST; FEMALE; FERRITINS; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PREVALENCE; PROGNOSIS; STROKE VOLUME; TRANSFERRIN; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84908009638     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1002/ejhf.161     Document Type: Article

References (27)

1. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Kober L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Ronnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, McDonagh T, Sechtem U, Bonet LA, Avraamides P, Ben Lamin HA, Brignole M, Coca A, Cowburn P, Dargie H, Elliott P, Flachskampf FA, Guida GF, Hardman S, Iung B, Merkely B, Mueller C, Nanas JN, Nielsen OW, Orn S, Parissis JT, Ponikowski P,. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2012; 14: 803-869.
2. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL,. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013; 62: e147-e239.
3. Jankowska EA, von Haehling S, Anker SD, Macdougall IC, Ponikowski P,. Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Eur Heart J 2013; 34: 816-829.
4. Klip IT, Comin-Colet J, Voors AA, Ponikowski P, Enjuanes C, Banasiak W, Lok DJ, Rosentryt P, Torrens A, Polonski L, van Veldhuisen DJ, van der Meer P, Jankowska EA,. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J 2013; 165: 575 -582 e3.
5. Santhanakrishnan R, Ng TP, Cameron VA, Gamble GD, Ling LH, Sim D, Leong GK, Yeo PS, Ong HY, Jaufeerally F, Wong RC, Chai P, Low AF, Lund M, Devlin G, Troughton R, Richards AM, Doughty RN, Lam CS,. The Singapore Heart Failure Outcomes and Phenotypes (SHOP) study and Prospective Evaluation of Outcome in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction (PEOPLE) study: rationale and design. J Card Fail 2013; 19: 156-162.
6. Paulus WJ, Tschope C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbely A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL,. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J 2007; 28: 2539-2550.
7. McKee PA, Castelli WP, McNamara PM, Kannel WB,. The natural history of congestive heart failure: the Framingham study. N Engl J Med 1971; 285: 1441-1446.
8. Tan CS, Chan YH, Wong TY, Gazzard G, Niti M, Ng TP, Saw SM,. Prevalence and risk factors for refractive errors and ocular biometry parameters in an elderly Asian population: the Singapore Longitudinal Aging Study (SLAS). Eye (Lond) 2011; 25: 1294-1301.
9. Henry WL, DeMaria A, Gramiak R, King DL, Kisslo JA, Popp RL, Sahn DJ, Schiller NB, Tajik A, Teichholz LE, Weyman AE,. Report of the American Society of Echocardiography Committee on Nomenclature and Standards in Two-dimensional Echocardiography. Circulation 1980; 62: 212-217.
10. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ,. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18: 1440-1463.
11. Levey AS, Coresh J, Greene T, Marsh J, Stevens LA, Kusek JW, Van Lente F,. Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values. Clin Chem 2007; 53: 766-772.
12. World Health Organization. Iron Deficiency Anaemia: Assessment, Prevention and Control. A Guide for Programme Managers. Geneva: WHO; 2001.
13. Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, Luscher TF, Bart B, Banasiak W, Niegowska J, Kirwan BA, Mori C, von Eisenhart RB, Pocock SJ, Poole-Wilson PA, Ponikowski P,. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361: 2436-2448.
14. Jankowska EA, Rozentryt P, Witkowska A, Nowak J, Hartmann O, Ponikowska B, Borodulin-Nadzieja L, Banasiak W, Polonski L, Filippatos G, McMurray JJ, Anker SD, Ponikowski P,. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. Eur Heart J 2010; 31: 1872-1880.
15. Jankowska EA, Rozentryt P, Witkowska A, Nowak J, Hartmann O, Ponikowska B, Borodulin-Nadzieja L, von Haehling S, Doehner W, Banasiak W, Polonski L, Filippatos G, Anker SD, Ponikowski P,. Iron deficiency predicts impaired exercise capacity in patients with systolic chronic heart failure. J Card Fail 2011; 17: 899-906.
16. Wish JB,. Assessing iron status: beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephrol 2006; 1 (Suppl 1): S4-S8.
17. Parikh A, Natarajan S, Lipsitz SR, Katz SD,. Iron deficiency in community-dwelling US adults with self-reported heart failure in the National Health and Nutrition Examination Survey III: prevalence and associations with anemia and inflammation. Circ Heart Fail 2011; 4: 599-606.
18. Thankachan P, Walczyk T, Muthayya S, Kurpad AV, Hurrell RF,. Iron absorption in young Indian women: the interaction of iron status with the influence of tea and ascorbic acid. Am J Clin Nutr 2008; 87: 881-886.
19. Nelson M, Poulter J,. Impact of tea drinking on iron status in the UK: a review. J Hum Nutr Diet 2004; 17: 43-54.
20. McGregor J, McKie AT, Simpson RJ,. Of mice and men: genetic determinants of iron status. Proc Nutr Soc 2004; 63: 11-20.
21. Atherton JJ, Hayward CS, Wan Ahmad WA, Kwok B, Jorge J, Hernandez AF, Liang L, Kociol RD, Krum H,. Patient characteristics from a regional multicenter database of acute decompensated heart failure in Asia Pacific (ADHERE International-Asia Pacific). J Card Fail 2012; 18: 82-88.
22. Lam CS, Anand I, Zhang S, Shimizu W, Narasimhan C, Park SW, Yu CM, Ngarmukos T, Omar R, Reyes EB, Siswanto B, Ling LH, Richards AM,. Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry. Eur J Heart Fail 2013; 15: 928-936.
23. Ng TP, Niti M,. Trends and ethnic differences in hospital admissions and mortality for congestive heart failure in the elderly in Singapore, 1991-1998. Heart 2003; 89: 865-870.
24. Kasner M, Aleksandrov AS, Westermann D, Lassner D, Gross M, von Haehling S, Anker SD, Schultheiss H-P, Tschöpe C,. Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction. Int J Cardiol 2013; 168: 4652-4657.
25. Avni T, Leibovici L, Gafter-Gvili A,. Iron supplementation for the treatment of chronic heart failure and iron deficiency: systematic review and meta-analysis. Eur J Heart Fail 2012; 14: 423-429.
26. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Kober L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Ronnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A,. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 2012; 33: 1787-847.
27. Krum H, Jelinek MV, Stewart S, Sindone A, Atherton JJ,. 2011 update to National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand Guidelines for the prevention, detection and management of chronic heart failure in Australia, 2006. Med J Aust 2011; 194: 405-409.