Recombinant rabies virus expressing IFNα1 enhanced immune responses resulting in its attenuation and stronger immunogenicity

Virology

Volumn 468, Issue , 2014, Pages 621-630

  Wang, Yifei ^a   Tian, Qin ^a   Xu, Xiaojuan ^a,c   Yang, Xianfeng ^a,d   Luo, Jun ^a   Mo, Weiyu ^a   Peng, Jiaojiao ^a   Niu, Xuefeng ^b   Luo, Yongwen ^a   Guo, Xiaofeng ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c Bureau of Animal Husbandry and Food Administration of Cangxi   (China)

^d INSTITUTE OF TROPICAL BIOSCIENCE AND BIOTECHNOLOGY   (China)

Author keywords

Interferon; Rabies virus; Vaccine

Indexed keywords

ALPHA1 INTERFERON; NEUTRALIZING ANTIBODY; ALPHA INTERFERON; LIVE VACCINE; MESSENGER RNA; RABIES VACCINE; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE ACTIVATION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RESPONSE; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; INNATE IMMUNITY; KUNMING MOUSE; LYMPH NODE; MOUSE; NONHUMAN; RABIES VIRUS; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL RATE; VIRAL CLEARANCE; VIRUS ATTENUATION; VIRUS RECOMBINANT; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; B LYMPHOCYTE; DOG; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETICS; HAMSTER; IMMUNOLOGY; METABOLISM; PATHOGENICITY; RABIES; T LYMPHOCYTE; VIROLOGY; VIRUS CULTURE; VIRUS REPLICATION;

RABIES VIRUS;

ANIMALS; B-LYMPHOCYTES; CRICETINAE; DOGS; GENE EXPRESSION REGULATION, VIRAL; GENETIC ENGINEERING; IMMUNITY, INNATE; INTERFERON-ALPHA; MICE; RABIES; RABIES VACCINES; RABIES VIRUS; RNA, MESSENGER; RNA, VIRAL; T-LYMPHOCYTES; VACCINES, ATTENUATED; VIRUS CULTIVATION; VIRUS REPLICATION;

EID: 84908000953     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2014.09.010     Document Type: Article

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