Does autoreactivity have a role in narcolepsy?

The Lancet Neurology

Volumn 13, Issue 11, 2014, Pages 1072-1073

  Partinen, Markku ^a,b   Kornum, Birgitte Rahbek ^c,d   Plazzi, Giuseppe ^e,f   Jennum, Poul ^d   Julkunen, Ilkka ^g,h   Vaarala, Outi ^b,i  

^a Vitalmed Research Centre   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e UNIVERSITY OF BOLOGNA   (Italy)

^f IRCCS ISTITUTO DELLE SCIENZE NEUROLOGICHE DI BOLOGNA   (Italy)

^g UNIVERSITY OF TURKU   (Finland)

^h NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

ⁱ ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; AUTOANTIBODY; CATHEPSIN H; EPITOPE; GLUTAMIC ACID; HLA ANTIGEN CLASS 2; HLA DQB1 ANTIGEN; IMMUNOGLOBULIN; INFLUENZA VACCINE; ISOLEUCINE; OREXIN; OX40 LIGAND; PURINERGIC P2Y11 RECEPTOR; T LYMPHOCYTE RECEPTOR;

AUTOIMMUNITY; AUTOREACTIVITY; DELAYED SLEEP PHASE; GENETIC ASSOCIATION; HUMAN; HYPERSOMNIA; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLUENZA A; INFLUENZA VIRUS A H1N1; LETTER; MOLECULAR MIMICRY; NARCOLEPSY; PARASOMNIA; PATHOGENESIS; PERIODIC LIMB MOVEMENT DISORDER; RESTLESS LEGS SYNDROME; SECONDARY IMMUNE RESPONSE; SLEEP DISORDER; SLEEP DISORDERED BREATHING; SLEEP PATTERN; STREPTOCOCCUS PYOGENES; UPPER RESPIRATORY TRACT INFECTION; IMMUNOLOGY; INFLUENZA; NEUROLOGIC DISEASE; VACCINATION; VIROLOGY;

AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; NARCOLEPSY; VACCINATION;

EID: 84907992684     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(14)70168-1     Document Type: Letter

References (4)

1. Partinen M, Kornum BR, Plazzi G, Jennum P, Julkunen I, Vaarala O Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination. Lancet Neurol 2014, 13:600-613.
2. De la Herrán-Arita AK, Kornum BR, Mahlios J, et al. Retraction of the Research Article: "CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy". Sci Transl Med 2014, 6:247rt1.
3. Bergman P, Adori C, Vas S, et al. Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. Proc Natl Acad Sci USA 2014, 111:E3735-E3744.
4. Katzav A, Arango MT, Kivity S, et al. Passive transfer of narcolepsy: anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice. J Autoimmun 2013, 45:24-30.