Simultaneous determination of nine lignans from Schisandra chinensis extract using ultra-performance liquid chromatography with tandem mass spectrometry in rat plasma, urine, and gastrointestinal tract samples: Application to the pharmacokinetic study of Schisandra chinensis

Journal of Separation Science

Volumn 37, Issue 20, 2014, Pages 2851-2863

  Kim, You Jin ^a   Lee, Hee Ju ^b   Kim, Chul Young ^c   Han, Sun Young ^d   Chin, Young Won ^a   Choi, Young Hee ^a  

^a Dongguk University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Hanyang University   (South Korea)

^d Gyeongsang National University   (South Korea)

Author keywords

Lignans; Liquid chromatography with tandem mass spectrometry; Pharmacokinetics; Rats; Schisandra chinensis

Indexed keywords

DIETARY SUPPLEMENTS; HEXANE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; RATING; RATS;

LIGNANS; LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRIES; PHARMACOKINETIC PARAMETERS; SAMPLE PREPARATION METHODS; SCHISANDRA CHINENSIS; SIMULTANEOUS DETERMINATIONS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION METHODOLOGIES;

EXTRACTION;

ANGELOYLGOMISIN H; GOMISIN; GOMISIN A; LIGNAN DERIVATIVE; SCHISANDRA CHINENSIS EXTRACT; SCHISANDRIN A; SCHISANDRIN C; SCHISANDROL A; SCHIZANDRIN B; TIGLOYLGOMISIN H; UNCLASSIFIED DRUG; LIGNAN; PLANT EXTRACT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG STABILITY; GASTROINTESTINAL TRACT EXAMINATION; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; SCHISANDRA CHINENSIS; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; VOLUME OF DISTRIBUTION AT STEADY-STATE; ANIMAL; BLOOD; CHEMISTRY; GASTROINTESTINAL TRACT; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; METABOLISM; PROCEDURES; REPRODUCIBILITY; SCHISANDRA; SPRAGUE DAWLEY RAT; URINE;

ANIMALS; CHROMATOGRAPHY, LIQUID; GASTROINTESTINAL TRACT; LIGNANS; LIMIT OF DETECTION; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SCHISANDRA; TANDEM MASS SPECTROMETRY;

EID: 84907982921     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201400451     Document Type: Article

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