Rejection of insulin therapy among patients with type 2 diabetes in China: Reasons and recommendations

Chinese Medical Journal

Volumn 127, Issue 20, 2014, Pages 3530-3536

  Xiong, Zhen Zhen ^a   Yuan, L ^a   Guo, Xiao Hui ^b   Lou, Qing Qing ^c   Zhao, Fang ^d   Shen, L ^c   Zhang, Ming Xia ^e   Sun, Zi Lin ^f  

^a SICHUAN UNIVERSITY   (China)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

^c Department of Health Education Jiangsu Province Integrated Chinese and Western Medicine Hospital ^*  (China)

^d CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^e PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^f AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Diabetes mellitus; Drug therapy; Insulin; Rejection; Type 2

Indexed keywords

GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C; INSULIN;

ADULT; ARTICLE; ATTITUDE; CHINA; CROSS-SECTIONAL STUDY; DATA ANALYSIS; DIABETES EDUCATION; DIABETIC FOOT; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DISEASE DURATION; FEMALE; FOLLOW UP; HEALTH SURVEY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFORMATION PROCESSING; INSULIN TREATMENT; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT COUNSELING; PHYSICIAN; POST HOC ANALYSIS; QUESTIONNAIRE; CLINICAL TRIAL; DIABETES MELLITUS, TYPE 2; MIDDLE AGED; PATIENT ATTITUDE; STATISTICS AND NUMERICAL DATA;

CHINA; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN; MALE; MIDDLE AGED; PATIENT ACCEPTANCE OF HEALTH CARE; QUESTIONNAIRES;

EID: 84907980365     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20141432     Document Type: Article

References (35)

1. U.K. Prospective Diabetes Study Group. Overview of 6 years’ therapy of type 2 diabetes: a progressive disease. Diabetes 1995; 44: 1249-1258.
2. Rolla A. Pharmacokinetic and pharmacodynamic advantages of insulin analogues and premixed insulin analogues over human insulins: impact on efficacy and safety. Am J Med 2008; 121: S9-S19.
3. Bolen S, Feldman L, Vassy J, Wilson L, Yeh HC, Marinopoulos S, et al. Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann Intern Medi 2007; 147: 386-399.
4. Coster S, Gulliford MC, Seed PT, Powrie JK, Swaminathan R. Monitoring blood glucose control in diabetes mellitus: a systematic review. Health Technol Assess 2000; 4: 1-93.
5. American Diabetes Association. Standards of medical care for patients with diabetes mellitus. Diab Care 2003; 26: S33-S50.
6. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. Br Med J 2000; 321: 405-412.
7. Wright A, Burden AC, Paisey RB, Cull CA, Holman RR, U.K. Prospective Diabetes Study Group. Sulfonylurea inadequacy: efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.K. Diab Care 2002; 25: 330-336.
8. Xu W, Li YB, Deng WP, Hao YT, Weng JP. Remission of hyperglycemia following intensive insulin therapy in newly diagnosed type 2 diabetic patients: a long-term follow-up study. Chin Med J 2009; 122: 2554-2559.
9. Weng J, Li Y, Xu W, Shi L, Zhang Q, Zhu D, et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 2008; 371: 1753-1760.
10. Chinese Diabetes Society. China Guideline for Type 2 Diabetes (in Chinese). Beijing: Peking University; 2011: 15-17.
11. United Kingdom Prospective Diabetes Study. Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. Br Med J 1995; 310: 83-88.
12. Donnan PT, MacDonald TM, Morris AD. Adherence to prescribed oral hypoglycaemic medication in a population of patients with Type 2 diabetes: a retrospective cohort study. Diab Med 2002; 19: 279-284.
13. Rubino A, McQuay LJ, Gough SC, Kvasz M, Tennis P. Delayed initiation of subcutaneous insulin therapy after failure of oral glucose-lowering agents in patients with Type 2 diabetes: a population-based analysis in the UK. Diab Med 2007; 24: 1412-1418.
14. Leslie CA, Satin-Rapaport W, Matheson DR, Stoner, Enfield G. Psychological insulin resistance: a missed diagnosis? Diab Spectr 1994; 7: 52-57.
15. Peyrot M, Rubin RR, Lauritzen T, Skovlund SE, Snoek FJ, Matthews DR, et al. Resistance to insulin therapy among patients and providers: results of the cross-national diabetes attitudes, wishes, and needs (DAWN) study. Diab Care 2005; 28: 2673-2679.
16. Chen CC, Chang MP, Hsieh MH, Huang CY, Liao LN, Li TC. Evaluation of perception of insulin therapy among Chinese patients with type 2 diabetes mellitus. Diab Metab 2011; 37: 389-394.
17. Xu LL, Pi YP, Wang GB, Liu XL, Wu J, Liu DX. Investigation of cognition and anxious state of type 2 diabetes mellitus accepted insulin-treatment (in Chinese). J Chongqing Med Univ 2009; 9: 1257-1259.
18. Pan C, Yang W, Jia W, Weng J, Liu G, Luo B, et al. Psychological status of Chinese patients with Type 2 diabetes: data review of Diabcare-China studies. Diabet Med 2012; 29: 515-521.
19. Xu Y, Wang L, He J, Bi Y, Li M, Wang T, et al. Prevalence and control of diabetes in Chinese adults. JAMA 2013; 310: 948-959.
20. Xu Y, Toobert D, Savage C, Pan W, Whitmer K. Factors influencing diabetes self-management in Chinese people with type 2 diabetes. Res Nurs Health 2008; 31: 613-625.
21. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diab Med 1998; 15: 539-553.
22. Guo XH, Yuan L, Lou QQ, Shen L, Sun ZL, Zhao F, et al. A nationwide survey of diabetes education, self-management and glycemic control in patients with type 2 diabetes in China. Chin Med J 2012; 125: 4175-4180.
23. Yuan L, Guo X, Xiong Z, Lou Q, Shen L, Zhao F, et al. Self-monitoring of blood glucose in type 2 diabetic patients in China: current status and influential factors. Chin Med J 2014; 127: 201-207.
24. Wei H. China’s national regional policy adjustment and prospect. J Southwest Univ Nat 2008; 10: 56-64.
25. Polonsky WH, Fisher L, Guzman S, Villa-Caballero L, Edelman SV. Psychological insulin resistance in patients with type 2 diabetes: the scope of the problem. Diab Care 2005; 28: 2543-2545.
26. Polonsky WH, Fisher L, Earles J, Dudl RJ, Lees J, Mullan J, et al. Assessing psychosocial distress in diabetes: development of the diabetes distress scale. Diab Care 2005; 28: 626-631.
27. Brod M, Kongso JH, Lessard S, Christensen TL. Psychological insulin resistance: patient beliefs and implications for diabetes management. Qual Life Res 2009; 18: 23-32.
28. Hunt LM, Valenzuela MA, Pugh JA. NIDDM patients' fears and hopes about insulin therapy. The basis of patient reluctance. Diab Care 1997; 20: 292-298.
29. Bahrmann A, Abel A, Zeyfang A, Petrak F, Kubiak T, Hummel J, et al. Psychological insulin resistance in geriatric patients with diabetes mellitus. Patient Edu Counsel 2014; 94: 417-422.
30. Nakar S, Yitzhaki G, Rosenberg R, Vinker S. Transition to insulin in Type 2 diabetes: family physicians' misconception of patients' fears contributes to existing barriers. J Diab Complicat 2007; 21: 220-226.
31. Zhang XS, Chen HN, Yang GQ. The evolution and factor of resident income difference among eastern, central, and western China (in Chinese). Shandong Soc Sci 2008; 8: 156-161.
32. Wang CZ, Wu XD. The analysis of regional difference of public health service in China. Future Dev 2010; 8: 29-36.
33. Valensi P, Benroubi M, Borzi V, Gumprecht J, Kawamori R, Shaban J, et al. The IMPROVE study--a multinational, observational study in type 2 diabetes: baseline characteristics from eight national cohorts. Int J Clin Pract 2008; 62: 1809-1819.
34. Fu AZ, Qiu Y, Radican L. Impact of fear of insulin or fear of injection on treatment outcomes of patients with diabetes. Curr Med Res Opin 2009; 25: 1413-1420.
35. Machinani S, Bazargan-Hejazi S, Hsia SH. Psychological insulin resistance among low-income, U.S. racial minority patients with type 2 diabetes. Prim Care Diab 2013; 7: 51.