Impact of fear of insulin or fear of injection on treatment outcomes of patients with diabetes

Current Medical Research and Opinion

Volumn 25, Issue 6, 2009, Pages 1413-1420

  Fu, Alex Z ^a   Qiu, Ying ^b   Radican, Larry ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Diabetes; Fear; Injection; Insulin; Psychological insulin resistance

Indexed keywords

HEMOGLOBIN A1C; INSULIN;

CARDIOVASCULAR DISEASE; COMORBIDITY; DIABETIC FOOT; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; FEAR; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT COMPLIANCE; POOR GENERAL CONDITION; QUALITY OF LIFE; REVIEW; SELF INJECTION; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

DIABETES MELLITUS; FEAR; HUMANS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; TREATMENT OUTCOME;

EID: 67649450091     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007990902905724     Document Type: Review

References (52)

1. American Diabetes Association: All about diabetes. Available at: http://www.diabetes.org/about-diabetes.jsp [Last accessed 5 August 2008]
2. American Diabetes Association. Economic costs of diabetes in the US in 2007. Diabetes Care 2008;31:596-615
3. Tabak AG, Tamas G, Zgibor J, et al. Targets and reality: a comparison of health care indicators in the U.S. (Pittsburgh Epidemiology of Diabetes Complications Study) and Hungary (DiabCare Hungary). Diabetes Care 2000;23:1284-1289
4. DeWitt DE, Hirsch IB. Outpatient insulin therapy in type 1 and type 2 diabetes mellitus: scientific review. JAMA 2003;289:2254-2264 (Pubitemid 37430194)
5. Nathan DM, Buse JB, Davidson MB, et al. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. Diabetes Care 2008;31:173-175
6. Petrak F, Stridde E, Leverkus F, et al. Development and validation of a new measure to evaluate psychological resistance to insulin treatment. Diabetes Care 2007;30:2199-2204 (Pubitemid 47359014)
7. Morris AD, Boyle DI, McMahon AD, et al., for the DARTS/MEMO Collaboration (Diabetes Audit and Research in Tayside Scotland; Medicines Monitoring Unit). Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus. Lancet 1997;350:1505-1510
8. Harris MI. Health care and health status and outcomes for patients with type 2 diabetes. Diabetes Care 2000;23:754-758 (Pubitemid 30414188)
9. de Sonnaville JJ, Snoek FJ, Colly LP, et al. Well-being and symptoms in relation to insulin therapy in type 2 diabetes. Diabetes Care 1998;21:919-924 (Pubitemid 28488782)
10. Alberti G. The DAWN (Diabetes Attitudes, Wishes and Needs) study. Pract Diabetes Int 2002;19:22-24
11. Peyrot M, Rubin RR, Lauritzen T, et al. Psychosocial problems and barriers to improved diabetes management: results of the cross-national Diabetes Attitudes, Wishes and Needs (DAWN) study. Diabet Med 2005;22:1379-1385
12. Hamilton JG. Needle phobia: a neglected diagnosis. J Fam Pract 1995;41:169-175
13. Leslie CA, Satin-Rapaport W, Matheson RN, et al. Psychological insulin resistance: a missed diagnosis? Diabetes Spectrum 1994;7:52-57
14. Peyrot M, Mathews DR, Snoek FJ, et al. An international study of psychological resistance to insulin use among persons with diabetes. Diabetologia 2003;46(Suppl. 2):A89
15. Nakar S, Yitzhaki G, Rosenberg R, et al. Transition to insulin in type 2 diabetes: family physicians' misconception of patients' fears contributes to existing barriers. Journal of Diabetes and its Complications 2007;21:220-226 (Pubitemid 47002315)
16. Polonsky WH, Jackson RA. What's so tough about taking insulin? Addressing the problem of psychological insulin resistance in type 2 diabetes. Clinical Diabetes 2004;22:147-150
17. Skovlund SE, van der Ven N, Pouwer F, et al. Appraisal of insulin treatment in type 2 diabetes patients with and without previous experience of insulin therapy (Abstract). Diabetes 2003;52:A419
18. Rubino A, McQuay LJ, Gough SC, et al. Delayed initiation of subcutaneous insulin therapy after failure of oral glucose-lowering agents in patients with type 2 diabetes: a population-based analysis in the UK. Diabet Med 2007;24:1412-1418 (Pubitemid 350179434)
19. Polonsky WH, Fisher L, Guzman S, et al. Psychological insulin resistance in patients with type 2 diabetes: the scope of the problem. Diabetes Care 2005;28:2543-2545 (Pubitemid 41384310)
20. Yki-Jarvinen H, Juurinen L, Alvarsson M, et al. INITIATE (INITiate Insulin by Aggressive Titration and Education). A randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups. Diabetes Care 2007;30:1364-1369
21. Bogatean MP, Hancu N. People with type 2 diabetes facing the reality of starting insulin therapy: factors involved in psychological insulin resistance. Practical Diabetes Int 2004;21:247-252 (Pubitemid 39307426)
22. Martinez L, Consoli SM, Monnier L, et al. Studying the hurdles of insulin prescription (SHIP): development, scoring and initial validation of a new self-administered questionnaire. Health Qual Life Outcome 2007;5:53 (Pubitemid 350020761)
23. Korytkowski M. When oral agents fail: practical barriers to starting insulin. Int J Obesity 2002;26(Suppl. 3):s18-s24 (Pubitemid 35034478)
24. Meece J. Dispelling myths and removing barriers about insulin in type 2 diabetes. Diabetes Educat 2006;32:S9-18 (Pubitemid 43206838)
25. Mollema ED, Snoek FJ, Heine RJ, et al. Phobia of self-injecting and self-testing in insulin-treated diabetes patients: opportunities for screening. Diabet Med 2001;18:671-674 (Pubitemid 32823067)
26. Goebel-Fabbri AE, Fikkan J, Franko DL, et al. Insulin restriction and associated morbidity and mortality in women with type 1 diabetes. Diabetes Care 2008;31:415-419
27. Bienvenu OJ, Eaton WW. The epidemiology of blood-injection-injury phobia. Psychol Med 1998;28:1129-1136 (Pubitemid 28458469)
28. Larkin ME, Capasso VA, Chen C, et al. Measuring psychological insulin resistance: barriers to insulin use. Diabetes Educat 2008;34:511-517
29. Zambanini A, Newson RB, Maisey M, et al. Injection related anxiety in insulin-treated diabetes. Diabetes Res Clin Pract 1999;46:239-246
30. Mollema ED, Snoek FJ, Heine RJ. Assessment of perceived barriers in self-care of insulin-requiring diabetic patients. Patient Educ Counsel 1996;29:277-281 (Pubitemid 27022591)
31. Mollema ED, Snoek FJ, Ader HJ, et al. Insulin-treated diabetes patients with fear of self-injecting or fear of self-testing: psychological comorbidity and general well-being. J Psychosom Res 2001;51:665-672 (Pubitemid 34007445)
32. Snoek FJ, Skovlund SE, Pouwer F. Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes. Health Qual Life Outcome 2007;5:69 (Pubitemid 351260313)
33. Metsch J, Tillil H, Kobberling J, et al. On the relation among psychological distress, diabetes-related health behavior, and level of glycosylated hemoglobin in type I diabetes. Int J Behav Med 1995;2:104-117
34. Berlin I, Bisserbe J, Eiber R, et al. Phobic symptoms, particularly the fear of blood and injury, are associated with poor glycemic control in type I diabetic adults. Diabetes Care 1997;20:176-178 (Pubitemid 27051557)
35. Bradley C, Gilbride CJB. Improving treatment satisfaction and other patient-reported outcomes in people with type 2 diabetes: the role of once-daily insulin glargine. Diabetes Obes Metabol 2008;10(Suppl. 2):50-65
36. Brod M, Christensen T, Bushnell D. Maximizing the value of validation findings to better understand treatment satisfaction issues for diabetes. Qual Life Res 2007;16:1053-1063 (Pubitemid 47174893)
37. The Diabetes Control and Complications Trial Research Group (DCCT). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-986
38. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-853
39. Koro CE, Bowlin SJ, Bourgeois N, et al. Glycemic control from 1988 to 2000 among U.S. adults diagnosed with type 2 diabetes. Diabetes Care 2004;27:17-20
40. Selvin E, Marinopoulos S, Berkenblit G, et al. Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 2004;141:421-431 (Pubitemid 39281878)
41. Diabetes Control and Complications Trial (DCCT) Research Group. Effect of intensive diabetes management on macrovascular events and risk factors in the diabetes control and complications trial. Am J Cardiol 1995;75:894-903
42. Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 1995;28:103-117
43. Lustman PJ. Anxiety disorders in adults with diabetes mellitus. Psychiatr Clin North Am 1988;11:419-432 (Pubitemid 18165933)
44. Mayou R, Peveler R, Davies B, et al. Psychiatric morbidity in young adults with insulin-dependent diabetes mellitus. Psychol Med 1991;1:639-645
45. Cappelleri JC, Cefalu WT, Rosenstock J, et al. Treatment satisfaction in type 2 diabetes: a comparison between an inhaled insulin regimen and a subcutaneous insulin regimen. Clin Ther 2002;24:552-564 (Pubitemid 34492877)
46. Testa MA, Simonson DC. Satisfaction and quality of life with premeal inhaled versus injected insulin in adolescents and adults with type 1 diabetes. Diabetes Care 2007;30:1399-1405 (Pubitemid 46871145)
47. Henry RR, Mudaliar SR, Howland III WC, et al. Inhaled insulin using the AERx insulin diabetes management system in healthy and asthmatic subjects. Diabetes Care 2003;26:764-769 (Pubitemid 36929341)
48. Harsch IA. Inhaled insulins: their potential in the treatment of diabetes mellitus. Treat Endocrinol 2005;4:131-138 (Pubitemid 41058380)
49. Stockl K, Ory C, Vanderlpas A, et al. An evaluation of patient preference for an alternative insulin delivery system compared to standard vial and syringe. Curr Med Res Opin 2007;23:133-146 (Pubitemid 46191679)
50. Hunt LM, Valenzuela MA, Pugh JA. NIDDM patients' fears and hopes about insulin therapy. Diabetes Care 1997;20:292-298
51. Snoek FJ, Mollema ED, Heine RJ, et al. Development and validation of the diabetes fear of injecting and self-testing questionnaires (D-FISQ): first findings. Diabet Med 1997;14:871-876 (Pubitemid 27448938)
52. Mollema ED, Snoek EJ, Pouwer F, et al. Diabetes fear of injecting and self-testing questionnaire. Diabetes Care 2000;23:765-769