Role of N-acetylcysteine in protecting against 2,5-hexanedione neurotoxicity in a rat model: Changes in urinary pyrroles levels and motor activity performance

Environmental Toxicology and Pharmacology

Volumn 38, Issue 3, 2014, Pages 807-813

  Torres, M Edite ^a,b   dos Santos, A P Marreilha ^a   Gonçalves, Luísa L ^b   Andrade, Vanda ^a   Batoréu, M Camila ^a   Mateus, M Luísa ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b INSTITUTO SUPERIOR DE CIÊNCIAS DA SAÚDE EGAS MONIZ   (Portugal)

Author keywords

2,5 Hexanedione; Behavioral assays; LC MS MS; N acetylcysteine; Pyrrole compounds; Urinary biomarkers

Indexed keywords

ACETONYLACETONE; ACETYLCYSTEINE; PYRROLE DERIVATIVE; 2,5-HEXANEDIONE; ALKANONE; NEUROPROTECTIVE AGENT; NEUROTOXIN; NORLEUCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS LINKING; DETOXIFICATION; DOSE RESPONSE; DRUG MECHANISM; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; MOTOR ACTIVITY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OUTCOME ASSESSMENT; PREDICTIVE VALUE; RAT; TANDEM MASS SPECTROMETRY; TREATMENT DURATION; URINALYSIS; ANIMAL; DRUG EFFECTS; URINE; WISTAR RAT;

ACETYLCYSTEINE; ANIMALS; CHROMATOGRAPHY, LIQUID; HEXANONES; MALE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NORLEUCINE; PYRROLES; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

EID: 84907971187     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2014.09.008     Document Type: Article

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