Prevalence and clinicoradiological analyses of patients with alzheimer disease coexisting multiple microbleeds

Journal of Stroke and Cerebrovascular Diseases

Volumn 23, Issue 9, 2014, Pages 2444-2449

  Nagasawa, Junpei ^a   Kiyozaka, Tetsuhito ^b   Ikeda, Ken ^a  

^a TOHO UNIVERSITY OMORI MEDICAL CENTER   (Japan)

^b Mishuku Hospital   (Japan)

Author keywords

Alzheimer's disease; Atherosclerosis; Cerebral amyloid angiopathy; Cerebral microbleed; Microbleed topography; Neurological profile

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT;

AGE; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN HEMORRHAGE; CLINICAL FEATURE; DEMENTIA; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; DYSLIPIDEMIA; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NEUROPATHOLOGY; NEURORADIOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; RETROSPECTIVE STUDY; SEX DIFFERENCE; SEX RATIO; SMOKING; WHITE MATTER; ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN ANGIOGRAPHY; COMPLICATION; INTRACRANIAL HEMORRHAGES; JAPAN; MICROCIRCULATION; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PREVALENCE; RADIOGRAPHY; RISK FACTOR; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ASIAN CONTINENTAL ANCESTRY GROUP; CEREBRAL ANGIOGRAPHY; FEMALE; HUMANS; INTRACRANIAL HEMORRHAGES; JAPAN; MAGNETIC RESONANCE IMAGING; MALE; MICROCIRCULATION; NEUROPSYCHOLOGICAL TESTS; PREVALENCE; RISK FACTORS;

EID: 84907966504     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2014.05.036     Document Type: Article

References (37)

1. G. McKhann, D. Drachman, and M. Folstein Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 34 1984 939 944
2. J. Attems Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms Acta Neuropathol 110 2005 345 359
3. F. Fazekas, R. Kleinert, and G. Roob Histopathologic analysis of foci of signal loss on gradient-echo T2∗-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds AJNR Am J Neuroradiol 20 1999 637 642
4. A. Tanaka, Y. Ueno, and Y. Nakayama Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas Stroke 30 1999 1637 1642
5. V.I. Kwa, C.L. Franke, and B. Verbeeten Jr. Silent intracerebral microhemorrhages in patients with ischemic stroke. Amsterdam Vascular Medicine Group Ann Neurol 44 1998 372 377
6. H. Hanyu, Y. Tanaka, and S. Shimizu Cerebral microbleeds in Alzheimer's disease J Neurol 250 2003 1496 1497
7. C. Cordonnier, and W.M. van der Flier Brain microbleeds and Alzheimer's disease: innocent observation or key player? Brain 134 2011 335 344
8. J.D. Goos, M.I. Kester, and F. Barkhof Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition Stroke 40 2009 3455 3460
9. J.D. Goos, W.J. Henneman, and J.D. Sluimer Incidence of cerebral microbleeds: a longitudinal study in a memory clinic population Neurology 74 2010 1954 1960
10. S.S. Won, L.B. Hwa, and E.J. Kim Clinical significance of microbleeds in subcortical vascular dementia Stroke 38 2007 1949 1951
11. Y. Yakushiji, T. Noguchi, and M. Hara Distributional impact of brain microbleeds on global cognitive function in adults without neurological disorder Stroke 43 2012 1800 1805
12. J.A. Pettersen, G. Sathiyamoorthy, and F.Q. Gao Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study Arch Neurol 65 2008 790 795
13. M.W. Vernooij, L.A. van der, and M.A. Ikram Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study Neurology 70 2008 1208 1214
14. S.H. Lee, S.M. Kim, and N. Kim Cortico-subcortical distribution of microbleeds is different between hypertension and cerebral amyloid angiopathy J Neurol Sci 258 2007 111 114
15. Y. Nakata-Kudo, T. Mizuno, and K. Yamada Microbleeds in Alzheimer disease are more related to cerebral amyloid angiopathy than cerebrovascular disease Dement Geriatr Cogn Disord 22 2006 8 14
16. C. Cordonnier, W.M. van der Flier, and J.D. Sluimer Prevalence and severity of microbleeds in a memory clinic setting Neurology 66 2006 1356 1360
17. Y. Nakata, K. Shiga, and K. Yoshikawa Subclinical brain hemorrhages in Alzheimer's disease: evaluation by magnetic resonance T2∗-weighted images Ann N Y Acad Sci 977 2002 169 172
18. Y. Yakushiji, C. Yokota, and N. Yamada Clinical characteristics by topographical distribution of brain microbleeds, with a particular emphasis on diffuse microbleeds J Stroke Cerebrovasc Dis 20 2011 214 221
19. L.O. Wahlund, F. Barkhof, and F. Fazekas A new rating scale for age-related white matter changes applicable to MRI and CT Stroke 32 2001 1318 1322
20. C. Cordonnier, S.R. Al-Shahi, and J. Wardlaw Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting Brain 130 2007 1988 2003
21. S.M. Greenberg, J.A. Eng, and M. Ning Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage Stroke 35 2004 1415 1420
22. D.J. Werring, D.W. Frazer, and L.J. Coward Cognitive dysfunction in patients with cerebral microbleeds on T2∗-weighted gradient-echo MRI Brain 127 2004 2265 2275
23. Y. Yakushiji, M. Nishiyama, and S. Yakushiji Brain microbleeds and global cognitive function in adults without neurological disorder Stroke 39 2008 3323 3328
24. S. Sveinbjornsdottir, S. Sigurdsson, and T. Aspelund Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location J Neurol Neurosurg Psychiatry 79 2008 1002 1006
25. A. Atri, J.J. Locascio, and J.M. Lin Prevalence and effects of lobar microhemorrhages in early-stage dementia Neurodegener Dis 2 2005 305 312
26. S. Tatsumi, M. Shinohara, and T. Yamamoto Direct comparison of histology of microbleeds with postmortem MR images: a case report Cerebrovasc Dis 26 2008 142 146
27. A.C. van Es, J. van der Grond, and A.J. de Craen Risk factors for cerebral microbleeds in the elderly Cerebrovasc Dis 26 2008 397 403
28. S.M. Greenberg, M.W. Vernooij, and C. Cordonnier Cerebral microbleeds: a guide to detection and interpretation Lancet Neurol 8 2009 165 174
29. K.M. Cullen, Z. Kocsi, and J. Stone Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages Neurobiol Aging 27 2006 1786 1796
30. M. Schrag, G. McAuley, and J. Pomakian Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study Acta Neuropathologica 119 2010 291 302
31. D.N. Orken, E. Uysal, and E. Timer New cerebral microbleeds in ischemic stroke patients on warfarin treatment: two-year follow-up Clin Neurol Neurosurg 115 2013 1682 1685
32. M.W. Vernooij, M.D. Haag, and A. van der Lugt Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study Arch Neurol 66 2009 714 720
33. T. Imaizumi, S. Inamura, and I. Kohama Antithrombotic drug uses and deep intracerebral hemorrhages in stroke patients with deep cerebral microbleeds J Stroke Cerebrovasc Dis 22 2013 869 875
34. T. Nishikawa, T. Ueda, and M. Kajiwara Cerebral microbleeds in patients with intracerebral hemorrhage are associated with previous cerebrovascular diseases and white matter hyperintensity, but not with regular use of antiplatelet agents Neurol Med Chir (Tokyo) 49 2009 333 339
35. T. Imaizumi, S. Inamura, and I. Kohama Nascent deep microbleeds and stroke recurrences J Stroke Cerebrovasc Dis 23 2014 520 528
36. P. Bentham, R. Gray, and E. Sellwood Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial Lancet Neurol 7 2008 41 49
37. E. Richard, R. Kuiper, and M.G. Dijkgraaf Vascular care in patients with Alzheimer's disease with cerebrovascular lesions-A randomized clinical trial J Am Geriatr Soc 57 2009 797 805