Alteration in humoral immunity is common among family members of patients with common variable immunodeficiency

Journal of Investigational Allergology and Clinical Immunology

Volumn 24, Issue 5, 2014, Pages 346-351

  Karakoc Aydiner, Elif ^a   Ozen, A O ^a   Baris, S ^a   Ercan, H ^b   Ozdemir, C ^a   Barlan, I B ^a  

^a MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b Medica Imaging Centre   (Turkey)

Author keywords

Allergy; Common variable immunodeficiency (CVID); Consanguinity; Family screening; Hypogammaglobulinemia; Immunoglobulin A (IgA) deficiency

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CHILD; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONSANGUINITY; CONTROLLED STUDY; ECZEMA; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMORAL IMMUNITY; LUNG FUNCTION; LYMPHOCYTE; MALE; NEUTROPHIL; PRICK TEST; QUESTIONNAIRE; RHINITIS; FAMILY; GENETICS; IMMUNOGLOBULIN A DEFICIENCY; IMMUNOLOGY; MIDDLE AGED;

ADOLESCENT; ADULT; COMMON VARIABLE IMMUNODEFICIENCY; FAMILY; FEMALE; HUMANS; IGA DEFICIENCY; IMMUNITY, HUMORAL; MALE; MIDDLE AGED;

EID: 84907963987     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Schaffer AA, Pfannstiel J, Webster AD, Plebani A, Hammarstrom L, Grimbacher B. Analysis of families with common variable immunodeficiency (CVID) and IgA deficiency suggests linkage of CVID to chromosome 16q. Hum Genet. 2006 Feb;118(6):725-9.
2. Espanol T, Catala M, Hernandez M, Caragol I, Bertran JM. Development of a common variable immunodeficiency in IgAdeficient patients. Clin Immunol Immunopathol 1996;80:333-5.
3. Vorechovsky I, Zetterquist H, Paganelli R, Koskinen S, Webster AD, Bjorkander J, Smith CI, Hammarstrom L. Family and linkage study of selective IgA deficiency and common variable immunodeficiency. Clin Immunol Immunopathol. 1995 Nov;77(2):185-92.
4. Aghamohammadi A, Sedighipour L, Saeed SE, Kouhkan A, Heydarzadeh M, Pourpak Z. Alterations in humoral immunity in relatives of patients with common variable immunodeficiency. J Investig Allergol Clin Immunol. 2008;18(4):266-71.
5. Burrows PD, Cooper MD. IgA deficiency. Adv Immunol. 1997;65:245-76. Review.
6. Papadopoulou A, Mermiri D, Taousani S, Triga M, Nicolaidou P, Priftis KN. Bronchial hyper-responsiveness in selective IgA deficiency. Pediatr Allergy Immunol. 2005 Sep;16(6):495-500.
7. Agondi RC, Barros MT, Rizzo LV, Kalil J, Giavina-Bianchi P. Allergic asthma in patients with common variable immunodeficiency. Allergy. 2010 Apr;65(4):510-5.
8. Bottcher MF, Haggstrom P, Bjorksten B, Jenmalm MC. Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age. Clin Exp Allergy. 2002 Sep;32(9):1293-8.
9. Ludviksson BR, Eiriksson TH, Ardal B, Sigfusson A, Valdimarsson H. Correlation between serum immunoglobulin A concentrations and allergic manifestations in infants. J Pediatr. 1992 Jul;121(1):23-7.
10. Ozen A, Baris S, Karakoc-Aydiner E, Ozdemir C, Bahceciler NN, Barlan IB. Outcome of hypogammaglobulinemia in children: immunoglobulin levels as predictors. Clin Immunol. 2010 Dec;137(3):374-83.
11. Bahceciler NN, Ozdemir C, Kucukosmanoglu E, Arikan C, Over U, Karavelioglu S, Akkoc T, Yazi D, Yesil O, Soysal A, Bakir M, Barlan IB. Association between previous enterobiasis and current wheezing: evaluation of 1018 children. Allergy Asthma Proc. 2007 Mar-Apr;28(2):174-82.
12. http://www.esid.org/clinical-diagnostic-criteria-for-pid-73-0#Q3
13. Polgar P, Promadhat V. Pulmonary testing in children. Philadelphia, PA, W.B. Saunders 1971.
14. Ozdemir C, Yazi D, Gocmen I, Yesil O, Aydogan M, Semic- Jusufagic A, Bahceciler NN, Barlan IB. Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacotherapy in house dust mite-allergic children with asthma. Pediatr Allergy Immunol. 2007;18:508-15.
15. Park JH, Resnick ES, Cunningham-Rundles C. Perspectives on common variable immune deficiency. Ann N Y Acad Sci. 2012;1246:41-9.
16. van de Ven AA, Compeer EB, van Montfrans JM, Boes M. B-cell defects in common variable immunodeficiency: BCR signaling, protein clustering and hardwired gene mutations. Crit Rev Immunol. 2011;31:85-98.
17. Schroder HW Jr, Zhu ZB, March RE, Campbell RD, Berney SM, Nedospasov SA, Turetskaya RL, Atkinson TP, Go RC, Cooper MD, Volanakis JE. Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, B8, A1 haplotype. Mol Med. 1998;4:72-86.
18. Martinez A, Vidal F, Vigil P, Conejero L, Garcia-Rodriguez MC, Fontan G: HLA class II homozygosity confers susceptibility to common variable immunodeficiency (CVID). Clin Exp Immunol 1999;116:516-20.
19. Vorechovsky I, Cullen M, Carrington M, Hammarström L, Webster AD. Fine mapping of IGAD1 in IgA deficiency and common variable immunodeficiency: identification and characterization of haplotypes shared by affected members of 101 multiple-case families. J Immunol. 2000;164:4408-16.
20. Kralovicova J, Hammarstrom L, Plebani A, Webster AD, Vorechovsky I. Fine-scale mapping at IGAD1 and genomewide genetic linkage analysis implicate HLA-DQ/DR as a major susceptibility locus in selective IgA deficiency and common variable immunodeficiency. J Immunol. 2003;170:2765-75.
21. Orange JS, Glessner JT, Resnick E, Sullivan KE, Lucas M, Ferry B, Kim CE, Hou C, Wang F, Chiavacci R, Kugathasan S, Sleasman JW, Baldassano R, Perez EE, Chapel H, Cunningham-Rundles C, Hakonarson H. Genome-wide association identifies diverse causes of common variable immunodeficiency. J. Allergy Clin. Immunol. 2011;127:1360-7.
22. Waldrep ML, Zhuang Y, Schroeder HW, Jr. Analysis of TACI mutations in CVID & RESPI patients who have inherited HLA B*44 or HLA*B8. BMC Med Genet. 2009;10:100.
23. Finck A, Van der Meer JW, Schaffer AA, Pfannstiel J, Fieschi C, Plebani A, Webster AD, Hammarström L, Grimbacher B. Linkage of autosomal-dominant common variable immunodeficiency to chromosome 4q. Eur. J Hum Genet. 2006;14:867-75.
24. Vorechovsky I, ADB Webster, A Plebani, and L Hammarström. 1999. Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences and the role of anti-IgA antibodies in disease predisposition. Am J Hum Genet. 1999;64:1096.
25. Gleeson M, Cripps AW, Clancy RL, Hensley MJ, Henry RJ, Wlodarczyk JH. The significance of transient mucosal IgA deficiency on the development of asthma and atopy in children. Adv Exp Med Biol. 1995;371B:861-4.
26. van Asperen PP, Gleeson M, Kemp AS, Cripps AW, Geraghty SB, Mellis CM, Clancy RL. The relationship between atopy and salivary IgA deficiency in infancy. Clin Exp Immunol. 1985 Dec;62(3):753-7.
27. Janzi M, Kull I, Sjöberg R, Wan J, Melén E, Bayat N, Ostblom E, Pan-Hammarström Q, Nilsson P, Hammarström L. Selective IgA deficiency in early life: association to infections and allergic diseases during childhood. Clin Immunol. 2009 Oct;133(1):78-85.
28. Franco A, Parrella R, Murru F, Ames PR, Martucci F, Rotiroti G, Manfroni PV, Cioffi D, Tommasino C, Esposito V. Lack of association between IgA deficiency and respiratory atopy in young male adults. In Vivo. 2011 Sep-Oct;25(5):829-32.
29. Aghamohammadi A, Cheraghi T, Gharagozlou M, Movahedi M, Rezaei N, Yeganeh M, Parvaneh N, Abolhassani H, Pourpak Z, Moin M. IgA deficiency: correlation between clinical and immunological phenotypes. J Clin Immunol. 2009 Jan;29(1):130-6.
30. Baris S, Karakoc-Aydiner E, Ozen A, Ozdemir C, Bahceciler NN, Barlan IB. Serum immunoglobulin levels as a predictive factor for a better outcome of non-atopic childhood asthma. Pediatr Allergy Immunol. 2011 May;22(3):298-304.
31. Kalyoncu AF, Demir AU, Ozcakar B, Bozkurt B, Artvinli M. Asthma and allergy in Turkish university students: Two crosssectional surveys 5 years apart. Allergol Immunopathol (Madr). 2001 Nov-Dec;29(6):264-71.