BRCA1 and γH2AX as independent prognostic markers in oral squamous cell carcinoma

Oncoscience

Volumn 1, Issue 5, 2014, Pages 383-391

  Oliveira Costa, Joao Paulo ^a,b   Oliveira, Lucinei Roberto ^c   Zanetti, Juliana Silva ^a   da Silveira, Giorgia Gobbi ^a   Chavichiolli Buim, Marcilei Eliza ^b   Zucoloto, Sergio ^a   Ribeiro Silva, Alfredo ^a   Soares, Fernando Augusto ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b A C CAMARGO CANCER CENTER   (Brazil)

^c Universidade Vale do Rio Verde   (Brazil)

Author keywords

BRCA1; DNA damage; H2AX; Oral squamous cell carcinoma; Prognostic factor

Indexed keywords

EID: 84907962974     PISSN: None     EISSN: 23314737     Source Type: Journal    
DOI: 10.18632/oncoscience.47     Document Type: Article

References (30)

1. Massano J, Regateiro FS, Januario G, Ferreira A. Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endo 2006; 102: 67-76.
2. Sargeran K, Murtomaa H, Safavi SM, Vehkalahti MM, Teronen O. Survival after diagnosis of cancer of the oral cavity. Br J Oral Maxillofac Surg. 2008; 46: 187-91.
3. Oliveira LR, Oliveira-Costa JP, Araujo IM, Soave DF, Zanetti JS, Soares FA, Zucoloto S, Ribeiro-Silva A. Cancer stem cell immunophenotypes in oral squamous cell carcinoma. J Oral Pathol Med. 2011; 40: 135-42.
4. Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, Dalerba P, Weissman IL, Clarke MF, Ailles LE. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA. 2007; 104: 973-78.
5. Wooster R. & Weber B. L. Breast and ovarian cancer. N. Engl. J. Med. 2003; 348: 2339-47.
6. Tutt A. & Ashworth A. The relationship between the roles of BRCA genes in DNA repair and cancer predisposition. Trends Mol. Med. 2002; 8: 571-6.
7. Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 2002; 108: 171-82.
8. Deng CX, Brodie SG. Roles of BRCA1 and its interacting proteins. Bioessays. 2000; 22; 728-37.
9. van Attikun H, Gasser SM. Crosstalk between the roles of BRCA genes in DNA repair and cancer predisposition. Trends Mol. Med. 2002; 8; 571-6.
10. Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domais involved in DNA double-strand breaks in vivo. J. Cell Biol. 1999; 146; 905-16.
11. Chen Y, Chen CF, Riley DJ, Allred DC, Chen PL, Von HoffD, Osborne CK, Lee WH. Aberrant Subcellular Localization of BRCA1 in Breast Cancer. Science 1995: 270 [5237], 789-791.
12. Lesnock JL, Darcy KM, Tian C, Deloia JA, Thrall MM, Zahn C, Armstrong DK, Birrer MJ, Krivak TC. BRCA1 expression and improved survival in ovarian cancer patients treated with intraperitoneal cisplatin and paclitaxel: a Gynecologic Oncology Group Study. British Journal of Cancer. 2013; 108: 1231-7.
13. Carser JE, Quinn JE, Michie CO, O'Brien EJ, McCluggage WG, Maxwell P, Lamers E, Lioe TF, Williams AR, Kennedy RD, Gourley C, Harkin DP. BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer. Gynecol Oncol. 2011; 123: 492-8.
14. Chen W, Wang J, Li X, Li J, Zhou L, Qiu T, Zhang M, Liu P. Prognostic significance of BRCA1 expression in gastric cancer. Med Oncol. 2013; 30: 423. doi: 10.1007/s12032-012-0423-5
15. Matthaios D, Foukas PG, Kefala M, Hountis P, Trypsianis G, Panayiotides IG, Chatzaki E, Pantelidaki E, Bouros D, Karakitsos P, Kakolyris S. γ-H2AX expression detected by immunohistochemistry correlates with prognosis in early operable non-small cell lung cancer. Onco Targets Ther. 2012; 5: 309-14.
16. Nagelkerke A, van Kuijk SJ, Sweep FC, Nagtegaal ID, Hoogerbrugge N, Martens JW, Timmermans MA, van Laarhoven HW, Bussink J, Span PN. Constitutive expression of γH2AX has prognostic relevance in triple negative breast cancer. Radiother Oncol. 2011; 101: 39-45.
17. Brunner AH, Hinterholzer S, Riss P, Heinze G, Weiss K, Brustmann H. Expression of γH2AX in endometrial carcinomas: an immunohistochemical study with p53. Gynecol Oncol. 2011; 121: 206-11.
18. Cheung WL, Albadine R, Chan T, Sharma R, Netto GJ. Phosphorilated H2AX in noninvasive low grade urothelial carcinoma of the bladder: correlation with tumor recurrence. J Urol. 2009; 181: 1387-92.
19. Garcia-Villa A, Balasubramanian P, Miller BL, Lustberg MB, Ramaswamy B, Chalmers JJ. Assessment of γ-H2AX levels in circulating tumor cells from patients receiving chemotherapy. Front Oncol. 2012; 2: 128. doi: 10.3389/fonc.2012.00128
20. Goutham HV, Mumbrekar KD, Vadhiraja BM, Fernandes DJ, Sharan K, Kanive Parashiva G, Kapaettu S, Bola Sadashiva SR. DNA double-strand break analysis by γ-H2AX foci: a useful method for determining the overreactors to radiation-induced acute reactions among head-and-neck cancer patients. Int J Radiat Oncol Biol Phys. 2012; 84: e607-12.
21. Li P, Du CR, Xu WC, Shi ZL, Zhang Q, Li ZB, Fu S. Correlation of dynamic changes in γ-H2AX expression in peripheral blood lymphocytes from head and neck cancer patients with radiation-induced oral mucositis. Radiat Oncol. 2013; 8: 155. doi: 10.1186/1748-717X-8-155.
22. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 1997; 88: 265-75.
23. Huen MSY, Sy SMH, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol. 2010; 11: 138-48.
24. da Silveira GG, Oliveira-Costa JP, Soave DF, Zanetti JS, Soares FA, Ribeiro-Silva A. Relationship between B-cellspecific Moloney murine leukemia virus integration site 1 (BMI-1) and homologous recombination regulatory genes in invasive ductal breast carcinomas. Histol Histopathol. 2012; 27: 1353-9.
25. World Health Organisation International Classification of Dieases-10. International statistical classification of diseases and related health problems. 1997 10th revision. Geneva, Switzerland: World Health Organisation.
26. Oliveira LR, Ribeiro-Silva A, Costa JP, Simoes AL, Matteo MA, Zucoloto S. Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 106: 685-95.
27. Braakhuis BJ, Tabor MP, Leemans CR, van der Waal I, Snow GB, BrakenhoffRH. Second primary tumors and field cancerization in oral and oropharyngeal cancer: molecular techniques provide new insights and definitions. Head Neck. 2002; 24: 198-206.
28. Pindborg JJ, Reichart PA, Smith CJ, van der Waal I, editors. World Health Organisation. International histological classification of tumors: histological typing of cancer and precancer of the oral mucosa. 2nd ed. Berlin/Heidelberg, Germany: Springer; 1997.
29. Wasco MJ, Pu RT. Comparison of PAX-2, RCC antigen, and antiphosphorylated H2AX antubody (γ-H2AX) in diagnosing metastatic renal cell carcinoma by fine-needle aspiration. Diagn Cytopathol. 2008; 36: 568-73.
30. PfafflMW. A new mathematical model for relative quantification in real-time RT-PCR. Nucl Acids Res. 2001; 29: e45. doi: 10.1093/nar/29.9.e45