Changing antimicrobial resistance profiles among Neisseria gonorrhoeae isolates in Italy, 2003 to 2012

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 10, 2014, Pages 5871-5876

  Carannante, Anna ^a   Renna, Giovanna ^a   Dal Conte, Ivano ^b   Ghisetti, Valeria ^b   Matteelli, Alberto ^c   Prignano, Grazia ^d   Impara, Giampaolo ^d   Cusini, Marco ^e   D'Antuono, Antonietta ^f   Vocale, Caterina ^f   Antonetti, Raffaele ^g   Gaino, Marina ^f   Busetti, Marina ^h   Latino, Maria Agnese ⁱ   Mencacci, Antonella ^j   Bonanno, Carmen ^k   Cava, Maria Carmela ^k   Giraldi, Cristina ^l   Stefanelli, Paola ^a   Del Re, S ^b   Milano, R ^b   Di Carlo, A ^d   Cristaudo, A ^d   Palamara, G ^d   Scioccati, L ^m   Ramoni, S ^m   De Francesco, M A ^c   Sambri, V ^f   Landini, M P ^f   Cavrini, F ^f   Fiore, J ^g   Di Taranto, A ^g   De Nittis, R ^g   Predazzer, R ^f   Ober, P ^f   Urbani, F ⁿ   Petix, V ^h   Rossi, T ^h   Pauri, P ^o   Meucci, M ^j   Tagliaferro, L ^p   Colaci, C ^p   more..

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b AMEDEO DI SAVOIA HOSPITAL   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

^d SAN GALLICANO DERMATOLOGICAL INSTITUTE   (Italy)

^e FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g Azienda Ospedaliero Univ OORR   (Italy)

^h INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

ⁱ Ospedale Ostetrico Ginecologico S Anna   (Italy)

^j UNIVERSITY OF PERUGIA   (Italy)

^k SANDRO PERTINI HOSPITAL   (Italy)

^l Azienda Ospedaliera Annunziata di Cosenza   (Italy)

^m Fondazione Policlinico Mangiagalli Regina Elena   (Italy)

ⁿ SANTA CHIARA HOSPITAL   (Italy)

^o Ospedale di Jesi   (Italy)

^p Laboratorio Dr Pignatelli Srl   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CEFIXIME; CIPROFLOXACIN; PENICILLIN DERIVATIVE; PENICILLINASE; SPECTINOMYCIN; TETRACYCLINE; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; EPSILOMETER TEST; FEMALE; GONORRHEA; HETEROSEXUALITY; HUMAN; IC50; ITALY; MALE; MEN WHO HAVE SEX WITH MEN; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NEISSERIA GONORRHOEAE; NONHUMAN; SEXUALLY TRANSMITTED DISEASE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; RETROSPECTIVE STUDY;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CEFIXIME; CIPROFLOXACIN; HUMANS; ITALY; MALE; NEISSERIA GONORRHOEAE; PENICILLINASE; PENICILLINS; RETROSPECTIVE STUDIES; TETRACYCLINE;

EID: 84907908968     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00103-14     Document Type: Article

References (36)

1. Dal Conte I, Starnino S, Di Perri G, Stefanelli P.2006.Disseminated gonococcal infection in an immunocompetent patient caused by an im- ported Neisseria gonorrhoeae multidrug-resistant strain. J. Clin. Microbiol. 44:3833-3834. http://dx.doi.org/10.1128/JCM.01041-06.
2. Walker CK, Sweet RL. 2011. Gonorrhea infection in women: prevalence, effects, screening and management. Int. J. Womens Health 3:197-206. http://dx.doi.org/10.2147/IJWH.S13427.
3. Barbee LA. 2014. Preparing for an era of untreatable gonorrhea. Curr. Opin. Infect. Dis. 27:282-287. http://dx.doi.org/10.1097/QCO.0000000000000058.
4. Lewis DA. 2014. Global resistance of Neisseria gonorrhoeae: when theory becomes reality. Curr. Opin. Infect. Dis. 27:62-67. http://dx.doi.org/10.1097/QC0.0000000000000025.
5. Ohnishi M, Golparian D, Shimuta K, Saika T, H0oshina S, Iwasaku K, Nakayama S, Kitawaki J, Unemo M. 2011. Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob. Agents Chemother. 55:3538-3545. http://dx.doi.org/10.1128/AAC.00325-11.
6. Shimuta K, Unemo M,Nakayama S,Morita-Ishihara T,Dorin M,Kawahata T,Ohnishi M,Antibiotic-Resistant Gonorrhea Study Group.2013.Antimicrobial resistance and molecular typing of Neisseria gonorrhoeae isolates in Kyoto and Osaka, Japan, 2010 to 2012: intensified surveillance after identification of the first strain (H041) with high-level ceftriaxone resistance. Antimicrob. Agents Chemother. 57:5225-5232. http://dx.doi.org/10.1128/AAC.01295-13.
7. Unemo M, Golparian D,Nicholas R,Ohnishi M, Gallay A, Sednaoui P. 2012. High-level cefixime and ceftriaxone resistant N. gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob. Agents Chemother. 56:1273-1280. http://dx.doi.org/10.1128/AAC.05760-11.
8. Cámara J, Serra J, Ayats J, Bastida T, Carnicer-Pont D, Andreu A, Ardanuy C. 2012. Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolated detected in Catalonia, Spain. J. Antimicrob. Chemother. 67:1858-1860. http://dx.doi.org/10.1093/jac/dks162.
9. Unemo M, Nicholas RA. 2012. Emergence of mutidrug-resistant, extensively drug-resistant and untreatable gonorrhea. Future Microbiol. 7:1401-1422. http://dx.doi.org/10.2217/fmb.12.117.
10. Unemo M, Golparian D, Shafer WM. 2014. Challenges with gonorrhea in the era of multi-drug and extensively drug resistance-are we on the right track? Expert Rev. Anti Infect. Ther. 12:653-656. http://dx.doi.org/10.1586/14787210.2014.906902.
11. Tapsall JW, Ndowa F, Lewis DA, Unemo M. 2009. Meeting the public health challenge of multidrug and extensively drug-resistant Neisseria gonorrhoeae. Expert Rev. Anti Infect. Ther. 7:821-834. http://dx.doi.org/10.1586/eri.09.63.
12. Bignell C, Unemo M, European STI Guidelines Editorial Board. 2013. 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults. Int. J. STD AIDS 24:85-92. http://dx.doi.org/10.1177/0956462412472837.
13. Centers for Disease Control and Prevention. 2012. Update to CDC's sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infection. MMWR Morb. Mortal Wkly. Rep. 61:590-594.
14. Van de Laar M. 2012. ECDC public health response to the threat of resistant gonorrhea in Europe. Euro. Surveill. 17(24):pii=20196. http: //www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20196.
15. European Centre for Disease Prevention and Control. 2013. Gonococcal antimicrobial susceptibility surveillance in Europe 2011. European Centre for Disease Prevention and Control. Stockholm, Sweden, http://www.ecdc.europa.eu/en/publications/publications/gonococcal-antimicrobial-susceptibility-surveillance-27-mar-2013.pdf.
16. European Centre for Disease Prevention and Control. 2013. Sexually transmitted infections in Europe 2011. European Centre for Disease Prevention and Control, Stockholm, Sweden, http://www.ecdc.europa.eu/en/publications/publications/sexually-transmittied-infections-europe-2011.pdf.
17. Spiteri G, Cole M, Unemo M, Hoffman S, Ison C, van de Laar M. 2013. The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP)-a sentinel approach in the European Union (EU)ZEuropean Economic Area (EEA). Sex. Transm. Infect. 89(Suppl 4):16-18. http://dx.doi.org/10.1136/sextrans-2013-051117.
18. Cole MJ, Unemo M, Hoffmann S, Chisholm SA, Ison CA, van der Laar MJ. 2011. The European Gonococcal Antimicrobial Surveillance Programme, 2009. Euro Surveill. 14(42):pii=19995. http://www.eurosurveillance.Org/ViewArticle.aspx?Articleld=19995.
19. European Committee on Antimicrobial Susceptibility Testing. 2014. Breakpoints tables for interpretation of MICs and zone diameters, version 4.0. European Committee on Antimicrobial Susceptibility Testing, Växjö, Sweden. http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST-files/Breakpoint-tables/Breakpoint-table-v-4.0.pdf.
20. Unemo M, Fasth O, Fredlund H, Limnios A, Tapsall J. 2009. Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes. J. Antimicrob. Chemother. 63:1142-1151. http://dx.doi.org/10.1093/jac/dkp098.
21. Martin IM, Ison CA, Aanensen DM, Fenton KA, Spratt BG. 2004. Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area. J. Infect. Dis. 189:1497-1505. http://dx.doi.org/10.1086/383047.
22. Chisholm SA, Unemo M, Quaye N, Johansson E, Cole MJ, Ison CA, Van de Laar M JW. 2013. Molecular epidemiological typing within the European Gonococcal Antimicrobial Resistance Surveillance Programme reveals predominance of a multidrug-resistant clone. Euro Surveill. 18(3): pii=20358. http://www.eurosurveilIance.org/ViewArtide.aspx?Artideld-20358.
23. Jeverica S, Golparian D, Maticic M, Potocnik M, Mlakar B, Unemo M. 2014. Phenotypic and molecular characterization of Neisseria gonorrhoeae isolates from Slovenia, 2006-12: rise and fall of the multi-drug-resistant NG-MAST genogroup 1407 clone? J. Antimicrob. Chemother. 69: 1517-1525. http://dx.doi.org/10.1093/jac/dku026.
24. European Centre for Disease Prevention and Control. 2012. Molecular typing of Neisseria gonorrhoeae. Results from a pilot study 2010-2011. European Centre for Disease Prevention and Control, Stockholm, Sweden. http://www.ecdc.europa.eu/en/publications/Publications/201211109-Molecular-typing-gonorrhea.pdf.
25. Starnino S, Neri A, Stefanelli P, Neisseria gonorrhoeae Italian Study Group. 2008. Molecular analysis of tetracycline-resistant gonococci: rapid detection of resistant genotypes using a real-time PCR assay. FEMS Microbiol. Lett. 286:16-23. http://dx.doi.Org/10.1111/j.1574-6968.2008.01244.x.
26. Starnino S, Suligoi B, Regine V, Bilek N, Stefanelli P, Neisseria gonorrhoeae Italian Study Group, Dal Conte I, Flanchino B, Delmonte S, Robbiano F, D'Antuono A, Mirone E, Matteelli A, De Francesco MA, Cu sini M, Scioccati L, Di Carlo A, Prignano G, Salfa MC. 2008. Phenotypic and genotypic characterization of Neisseria gonorrhoeae in parts of Italy: detection of a multiresistant cluster circulating in a heterosexual network. Clin. Microbiol. Infect. 14:949-954. http://dx.doi.org/10.1111/j.1469-0691.2008.02071,x.
27. Unemo M, Ison CA, Cole M, Spiteri G, van de Laar M, Khotenashvili L. 2013. Gonorrhoea and gonococcal antimicrobial resistance surveillance networks in the WHO European Region, including the independent countries of the former Soviet Union. Sex. Transm. Infect. 89(Suppl 4): iv42-iv46. http://dx.doi.org/10.1136/sextrans2012-050909.
28. Lahra MM, Lo YR, Whiley DM. 2013. Gonococcal antimicrobial resistance in the Western Pacific Region. Sex. Transm. Infect. 89(Suppl 4): ivl9-iv23. http://dx.doi.org/10.1136/sextrans-2012-050906.
29. Ndowa FJ, Francis JM, Machiha A, Faye-Kette H, Fonkoua MC. 2013. Gonococcal antimicrobial resistance: perspectives from African region. Sex. Transm. Infect. 89(Suppl 4):iv11-iv15. http://dx.doi.org/10.1136/sextrans-2012-050907.
30. Cole MJ, Chisholm SA, Hoffmann S, Stary A, Lowndes CM, Ison CA, the European Surveillance of Sexually Transmitted Infections Network. 2010. European surveillance of antimicrobial resistance in Neisseria gonorrhoeae. Sex. Transm. Infect. 86:427-432. http://dx.doi.org/10.1136/sti.2010.044164.
31. Tanaka M. 2012. Emergence of multidrug-resistant Neisseria gonorrhoeae strains circulating worldwide. Int. J. Urol. 19:98-99. http://dx.doi.org/10.1111/j.1442-2042.2011.02891.x.
32. World Health Organization. 2012. Global action plan to control the spread and impact of anti-microbial resistance in Neisseria gonorrhoeae. World Health Organization, Geneva, Switzerland, http://whqlibdoc.who.int/publications/2012/9789241503501-eng.pdf.
33. Unemo M, Golparian D, Syversen G, Vestrheim DF, Moi H. 2010. Two cases of verified clinical failures using internationally recommended firstline cefixime for gonorrhoea treatment, Norway. Euro Surveill. 15(47):pii=19721. http://www.eurosurveillance.org/ViewArticle.aspxi?ArticleId=19721.
34. Unemo M, Golparian D, Stary A, Eigentier A. 2011. First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011. Euro Surveill. 16(43):pii= 19998. http: //www.eurosurveillance.org/ViewArticle.aspx?ArticleId= 19998.
35. Carannante A, Prignano G, Cusini M, Matteelli A, Dal Conte I, Ghisetti V, D'Antuono A, Cavrini F, Antonetti R, Stefanelli P. 2012. Cefixime and ceftriaxone susceptibility of Neisseria gonorrhoeae in Italy from 2006 to 2010. Clin. Microbiol. Infect. 18:558-564. http://dx.doi.org/10.1111/i.1469-0691.2011.03619.x.
36. Carannante A, Latini A, Cusini M, Matteelli A, Dal Conte I, Ghisetti V, D'Antuono A, Cavrini F, Antonetti R, Stefanelli P. 2012. Update on antimicrobial susceptibility and genotype of Neisseria gonorrhoeae isolated in Italy. Diagn. Microbiol. Infect. Dis. 72:288-290. http://dx.doi.org/10.1016/j.diagmicrobio.2011.08.014.