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Volumn 16, Issue 10, 2014, Pages 518-525

Internal standard capillary electrophoresis as a high-throughput method for p K a determination in drug discovery and development

Author keywords

acidity constant; capillary electrophoresis; high throughput method; internal standard; IS CE; p K a determination

Indexed keywords

BUFFER;

EID: 84907892469     PISSN: 21568952     EISSN: None     Source Type: Journal    
DOI: 10.1021/co500059p     Document Type: Article
Times cited : (25)

References (32)
  • 3
    • 84862951503 scopus 로고    scopus 로고
    • High-Throughput Purification Platform in Support of Drug Discovery
    • Vachal, P.; Tata, J.; Athanasopoulos, J. High-Throughput Purification Platform in Support of Drug Discovery ACS Comb. Sci. 2012, 14, 51-59
    • (2012) ACS Comb. Sci. , vol.14 , pp. 51-59
    • Vachal, P.1    Tata, J.2    Athanasopoulos, J.3
  • 4
    • 33845242901 scopus 로고    scopus 로고
    • Enhanced Performance Test Mix for High-Throughput LC/MS Analysis of Pharmaceutical Compounds
    • Li, S.; Julien, L.; Tidswell, P.; Goetzinger, W. Enhanced Performance Test Mix for High-Throughput LC/MS Analysis of Pharmaceutical Compounds J. Comb. Chem. 2006, 8, 820-828
    • (2006) J. Comb. Chem. , vol.8 , pp. 820-828
    • Li, S.1    Julien, L.2    Tidswell, P.3    Goetzinger, W.4
  • 5
    • 33846204780 scopus 로고    scopus 로고
    • High-Throughput pKa Screening and Prediction Amenable for ADME Profiling
    • Wan, H.; Ulander, J. High-Throughput pKa Screening and Prediction Amenable for ADME Profiling Expert Opin. Drug Metab. Toxicol. 2006, 2, 139-155
    • (2006) Expert Opin. Drug Metab. Toxicol. , vol.2 , pp. 139-155
    • Wan, H.1    Ulander, J.2
  • 7
    • 0027496780 scopus 로고
    • Automated pKa Determination at Low Solute Concentrations by Capillary Electrophoresis
    • Cleveland, J. A., Jr.; Benko, M. H.; Gluck, S. J.; Walbroehl, Y. M. Automated pKa Determination at Low Solute Concentrations by Capillary Electrophoresis J. Chromatogr. A 1993, 652, 301-308
    • (1993) J. Chromatogr. A , vol.652 , pp. 301-308
    • Cleveland, J.A.1    Benko, M.H.2    Gluck, S.J.3    Walbroehl, Y.M.4
  • 8
    • 0030595278 scopus 로고    scopus 로고
    • Determination of Acidity Constants of Monoprotic and Diprotic Acids by Capillary Electrophoresis
    • Gluck, S. J.; Steele, K. P.; Benkö, M. H. Determination of Acidity Constants of Monoprotic and Diprotic Acids by Capillary Electrophoresis J. Chromatogr. A 1996, 745, 117-125
    • (1996) J. Chromatogr. A , vol.745 , pp. 117-125
    • Gluck, S.J.1    Steele, K.P.2    Benkö, M.H.3
  • 9
    • 0037194226 scopus 로고    scopus 로고
    • Determination of pKa Values of Quinolones from Mobility and Spectroscopic Data Obtained by Capillary Electrophoresis and a Diode Array Detector
    • Jiménez-Lozano, E.; Marqués, I.; Barrón, D.; Beltrán, J. L.; Barbosa, J. Determination of pKa Values of Quinolones from Mobility and Spectroscopic Data Obtained by Capillary Electrophoresis and a Diode Array Detector Anal. Chim. Acta 2002, 464, 37-45
    • (2002) Anal. Chim. Acta , vol.464 , pp. 37-45
    • Jiménez-Lozano, E.1    Marqués, I.2    Barrón, D.3    Beltrán, J.L.4    Barbosa, J.5
  • 10
    • 2342640927 scopus 로고    scopus 로고
    • Determination of Acid Dissociation Constants by Capillary Electrophoresis
    • Poole, S. K.; Patel, S.; Dehring, K.; Workman, H.; Poole, C. F. Determination of Acid Dissociation Constants by Capillary Electrophoresis J. Chromatogr. A 2004, 1037, 445-454
    • (2004) J. Chromatogr. A , vol.1037 , pp. 445-454
    • Poole, S.K.1    Patel, S.2    Dehring, K.3    Workman, H.4    Poole, C.F.5
  • 11
    • 20444406842 scopus 로고    scopus 로고
    • Determination of Dissociation Constants of Flavonoids by Capillary Electrophoresis
    • Herrero-Martinez, J. M.; Sanmartin, M.; Roses, M.; Bosch, E.; Rafols, C. Determination of Dissociation Constants of Flavonoids by Capillary Electrophoresis Electrophoresis 2005, 26, 1886-1895
    • (2005) Electrophoresis , vol.26 , pp. 1886-1895
    • Herrero-Martinez, J.M.1    Sanmartin, M.2    Roses, M.3    Bosch, E.4    Rafols, C.5
  • 12
    • 56149100060 scopus 로고    scopus 로고
    • Standard Systems for Measurement of pKs and Ionic Mobilities: 1.Univalen Weak Acids
    • Šlampová, A.; Křivánková, L.; Gebauer, P.; Boček, P. Standard Systems for Measurement of pKs and Ionic Mobilities: 1.Univalen Weak Acids J. Chromatogr. A 2008, 1213, 25-30
    • (2008) J. Chromatogr. A , vol.1213 , pp. 25-30
    • Šlampová, A.1    Křivánková, L.2    Gebauer, P.3    Boček, P.4
  • 14
    • 34547792223 scopus 로고    scopus 로고
    • A Comparative Study of Capillary Zone Electrophoresis and pH-Potentiometry for Determination of Dissociation Constants
    • Andrasi, M.; Buglyo, P.; Zekany, L.; Gaspar, A. A Comparative Study of Capillary Zone Electrophoresis and pH-Potentiometry for Determination of Dissociation Constants J. Pharm. Biomed. Anal. 2007, 44, 1040-1047
    • (2007) J. Pharm. Biomed. Anal. , vol.44 , pp. 1040-1047
    • Andrasi, M.1    Buglyo, P.2    Zekany, L.3    Gaspar, A.4
  • 15
    • 0035958306 scopus 로고    scopus 로고
    • Comparison between Capillary Electrophoresis, Liquid Chromatography, Potentiometric and Spectrophotometric Techniques for Evaluation of pKa Values of Zwitterionic Drugs in Acetonitrile-Water Mixtures
    • Barbosa, J.; Barrón, D.; Jiménez-Lozano, E.; Sanz-Nebot, V. Comparison between Capillary Electrophoresis, Liquid Chromatography, Potentiometric and Spectrophotometric Techniques for Evaluation of pKa Values of Zwitterionic Drugs in Acetonitrile-Water Mixtures Anal. Chim. Acta 2001, 437, 309-321
    • (2001) Anal. Chim. Acta , vol.437 , pp. 309-321
    • Barbosa, J.1    Barrón, D.2    Jiménez-Lozano, E.3    Sanz-Nebot, V.4
  • 16
    • 0037288040 scopus 로고    scopus 로고
    • The Preparation of Background Electrolytes in Capillary Zone Electrophoresis: Golden Rules and Pitfalls
    • Beckers, J. L.; Bocek, P. The Preparation of Background Electrolytes in Capillary Zone Electrophoresis: Golden Rules and Pitfalls Electrophoresis 2003, 24, 518-535
    • (2003) Electrophoresis , vol.24 , pp. 518-535
    • Beckers, J.L.1    Bocek, P.2
  • 17
    • 47549115080 scopus 로고    scopus 로고
    • Critical Evaluation of Buffering Solutions for pKa Determination by Capillary Electrophoresis
    • Fuguet, E.; Reta, M.; Gibert, C.; Rosés, M.; Bosch, E.; Ràfols, C. Critical Evaluation of Buffering Solutions for pKa Determination by Capillary Electrophoresis Electrophoresis 2008, 29, 2841-2851
    • (2008) Electrophoresis , vol.29 , pp. 2841-2851
    • Fuguet, E.1    Reta, M.2    Gibert, C.3    Rosés, M.4    Bosch, E.5    Ràfols, C.6
  • 18
    • 72449142659 scopus 로고    scopus 로고
    • A Fast Method for pKa Determination by Capillary Electrophoresis
    • Fuguet, E.; Ràfols, C.; Bosch, E.; Rosés, M. A Fast Method for pKa Determination by Capillary Electrophoresis Chem. Biodiversity 2009, 6, 1822-1827
    • (2009) Chem. Biodiversity , vol.6 , pp. 1822-1827
    • Fuguet, E.1    Ràfols, C.2    Bosch, E.3    Rosés, M.4
  • 19
    • 63249107555 scopus 로고    scopus 로고
    • Fast High-Throughput Method for the Determination of Acidity Constants by Capillary Electrophoresis: I. Monoprotic Weak Acids and Bases
    • Fuguet, E.; Ràfols, C.; Bosch, E.; Rosés, M. Fast High-Throughput Method for the Determination of Acidity Constants by Capillary Electrophoresis: I. Monoprotic Weak Acids and Bases J. Chromatogr. A 2009, 1216, 3646-3651
    • (2009) J. Chromatogr. A , vol.1216 , pp. 3646-3651
    • Fuguet, E.1    Ràfols, C.2    Bosch, E.3    Rosés, M.4
  • 20
    • 78649860322 scopus 로고    scopus 로고
    • Fast High-Throughput Method for the Determination of Acidity Constants by Capillary Electrophoresis. II. Acidic Internal Standards
    • Cabot, J. M.; Fuguet, E.; Ràfols, C.; Rosés, M. Fast High-Throughput Method for the Determination of Acidity Constants by Capillary Electrophoresis. II. Acidic Internal Standards J. Chromatogr. A 2010, 1217, 8340-8345
    • (2010) J. Chromatogr. A , vol.1217 , pp. 8340-8345
    • Cabot, J.M.1    Fuguet, E.2    Ràfols, C.3    Rosés, M.4
  • 21
    • 79957722621 scopus 로고    scopus 로고
    • A Fast High Throughput Method for the Determination of Acidity Constants by Capillary Electrophoresis. 3. Basic Internal Standards
    • Fuguet, E.; Ràfols, C.; Rosés, M. A Fast High Throughput Method for the Determination of Acidity Constants by Capillary Electrophoresis. 3. Basic Internal Standards J. Chromatogr. A 2011, 1218, 3928-3934
    • (2011) J. Chromatogr. A , vol.1218 , pp. 3928-3934
    • Fuguet, E.1    Ràfols, C.2    Rosés, M.3
  • 22
    • 84873322153 scopus 로고    scopus 로고
    • Determination of Acidity Constants by the Capillary Electrophoresis Internal Standard Method. IV. Polyprotic Compounds
    • Cabot, J. M.; Fuguet, E.; Ràfols, C.; Rosés, M. Determination of Acidity Constants by the Capillary Electrophoresis Internal Standard Method. IV. Polyprotic Compounds J. Chromatogr. A 2013, 1279, 108-116
    • (2013) J. Chromatogr. A , vol.1279 , pp. 108-116
    • Cabot, J.M.1    Fuguet, E.2    Ràfols, C.3    Rosés, M.4
  • 23
    • 84876331074 scopus 로고    scopus 로고
    • Temperature Variation Effects on the Determination of Acidity Constants through the Internal Standard-Capillary Electrophoresis Method
    • Gravador, R. S.; Fuguet, E.; Ràfols, C.; Rosés, M. Temperature Variation Effects on the Determination of Acidity Constants through the Internal Standard-Capillary Electrophoresis Method Electrophoresis 2013, 34, 1203-1211
    • (2013) Electrophoresis , vol.34 , pp. 1203-1211
    • Gravador, R.S.1    Fuguet, E.2    Ràfols, C.3    Rosés, M.4
  • 24
    • 0035468033 scopus 로고    scopus 로고
    • Physicochemical Profiling (Solubility, Permeability and Charge State)
    • Avdeef, A. Physicochemical Profiling (Solubility, Permeability and Charge State) Curr. Trends Med. Chem. 2001, 1, 277-351
    • (2001) Curr. Trends Med. Chem. , vol.1 , pp. 277-351
    • Avdeef, A.1
  • 25
    • 30344440543 scopus 로고    scopus 로고
    • Solubility in Water and DMSO: Issues and Potential Solutions
    • Lipinski, C. A. Solubility in Water and DMSO: Issues and Potential Solutions Biotechnol.: Pharm. Aspects 2004, 1, 93-125
    • (2004) Biotechnol.: Pharm. Aspects , vol.1 , pp. 93-125
    • Lipinski, C.A.1
  • 26
    • 79952783519 scopus 로고    scopus 로고
    • Drug Solubility in Water and Dimethylsulfoxide
    • Lipinski, C. Drug Solubility in Water and Dimethylsulfoxide Methods Princ. Med. Chem. 2008, 37, 257-282
    • (2008) Methods Princ. Med. Chem. , vol.37 , pp. 257-282
    • Lipinski, C.1
  • 27
    • 0037032612 scopus 로고    scopus 로고
    • Rapid Screening of pKa Values of Pharmaceuticals by Pressure-Assisted Capillary Electrophoresis Combined with Short-End Injection
    • Wan, H.; Holmén, A.; Nagard, M.; Lindberg, W. Rapid Screening of pKa Values of Pharmaceuticals by Pressure-Assisted Capillary Electrophoresis Combined with Short-End Injection J. Chromatogr. A 2002, 979, 369-377
    • (2002) J. Chromatogr. A , vol.979 , pp. 369-377
    • Wan, H.1    Holmén, A.2    Nagard, M.3    Lindberg, W.4
  • 28
    • 77955917770 scopus 로고    scopus 로고
    • Determination of pKa Values of Benzimidazole Derivatives from Mobility Obtained by Capillary Electrophoresis
    • Lipka, E.; Folly-Klan, M.; Charton, J.; Vaccher, M.-P.; Bonte, J.-P.; Vaccher, C. Determination of pKa Values of Benzimidazole Derivatives from Mobility Obtained by Capillary Electrophoresis J. Pharm. Biomed. Anal. 2010, 53, 1267-1271
    • (2010) J. Pharm. Biomed. Anal. , vol.53 , pp. 1267-1271
    • Lipka, E.1    Folly-Klan, M.2    Charton, J.3    Vaccher, M.-P.4    Bonte, J.-P.5    Vaccher, C.6
  • 29
    • 34249329593 scopus 로고    scopus 로고
    • a Values of Benzoxa-, Benzothia-, and Benzoselena-Zolinone Derivatives by Capillary Electrophoresis. Comparison with Potentiometric Titration and Spectrometric Data
    • a Values of Benzoxa-, Benzothia-, and Benzoselena-Zolinone Derivatives by Capillary Electrophoresis. Comparison with Potentiometric Titration and Spectrometric Data Eur. J. Pharm. Sci. 2007, 31, 165-171
    • (2007) Eur. J. Pharm. Sci. , vol.31 , pp. 165-171
    • Foulon, C.1    Duhal, N.2    Lacroix-Callens, B.3    Vaccher, C.4    Bonte, J.P.5    Goossens, J.F.6
  • 30
    • 84988072580 scopus 로고
    • Variation of the pH of the Background Electrolyte as a Result of Electrolysis in Capillary Electrophoresis
    • Zhu, T.; Sun, Y.; Zhang, C.; Ling, D.; Sun, Z. Variation of the pH of the Background Electrolyte as a Result of Electrolysis in Capillary Electrophoresis J. High Resolut. Chromatogr. 1994, 17, 563-564
    • (1994) J. High Resolut. Chromatogr. , vol.17 , pp. 563-564
    • Zhu, T.1    Sun, Y.2    Zhang, C.3    Ling, D.4    Sun, Z.5
  • 31
    • 0037442580 scopus 로고    scopus 로고
    • High-Throughput Measurement of P K a Values in a Mixed-Buffer Linear pH Gradient System
    • Box, K.; Bevan, C.; Comer, J.; Hill, A.; Allen, R.; Reynolds, D. High-Throughput Measurement of P K a Values in a Mixed-Buffer Linear pH Gradient System Anal. Chem. 2003, 75, 883-892
    • (2003) Anal. Chem. , vol.75 , pp. 883-892
    • Box, K.1    Bevan, C.2    Comer, J.3    Hill, A.4    Allen, R.5    Reynolds, D.6
  • 32
    • 60749105377 scopus 로고    scopus 로고
    • Using Measured pKa, LogP and Solubility to Investigate Supersaturation and Predict BCS Class
    • Box, K. J.; Comer, J. E. A. Using Measured pKa, LogP and Solubility to Investigate Supersaturation and Predict BCS Class Curr. Drug Metab. 2008, 9, 869-878
    • (2008) Curr. Drug Metab. , vol.9 , pp. 869
    • Box, K.J.1    Comer, J.E.A.2


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