Serotonin enhances megakaryopoiesis and proplatelet formation via p-Erk1/2 and F-actin reorganization

Stem Cells

Volumn 32, Issue 11, 2014, Pages 2973-2982

  Ye, Jie Yu ^a   Liang, En Yu ^a   Cheng, Yuan Shan ^b   Chan, Godfrey C F ^c   Ding, Yue ^c   Meng, Fanyi ^a   Ng, Margaret H L ^d   Chong, Beng H ^e   Lian, Qizhou ^c   Yang, Mo ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Megakaryopoiesis; melatonin; p Erk1 2; Proplatelet; Serotonin

Indexed keywords

ACTINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; SEROTONIN;

ANIMALS; BLOOD PLATELETS; CYTOLOGY; CYTOSKELETON; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MEGAKARYOCYTES; METABOLISM; MICE; PHYSIOLOGY;

ACTINS; ANIMALS; BLOOD PLATELETS; CYTOSKELETON; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MEGAKARYOCYTES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 3; SEROTONIN;

EID: 84907891286     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1777     Document Type: Article

References (39)

1. Janeway T, Richardson H, Park, E,. Experiments on the vasoconstrictor action of blood serum. Arch Intern Med 1918; 21: 7.
2. Folk GE Jr, Long JP,. Serotonin as a neurotransmitter: A review. Comp Biochem Physiol C 1988; 91: 251-257.
3. Nemecek GM, Coughlin SR, Handley DA, et al. Stimulation of aortic smooth muscle cell mitogenesis by serotonin. Proc Natl Acad Sci U S A 1986; 83: 674-678.
4. Seuwen K, Magnaldo I, Pouyssegur J,. Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein. Nature 1988; 335: 254-256.
5. Dooley AE, Pappas IS, Parnavelas JG,. Serotonin promotes the survival of cortical glutamatergic neurons in vitro. Exp Neurol 1997; 148: 205-214.
6. Rupprecht HD, Dann P, Sukhatme VP, Sterzel RB, Coleman DL,. Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: Correlation with mitogenicity. Am J Physiol 1992; 263: F623-F236.
7. Nebigil CG, Choi DS, Dierich A, et al. Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci U S A 2000; 97: 9508-9513.
8. Lesurtel M, Graf R, Aleil B, et al. Platelet-derived serotonin mediates liver regeneration. Science 2006; 312: 104-107.
9. Tanaka C, Kuruma I, Kuramoto A,. Histochemical demonstration of 5-hydroxytryptamine in platelets and megakaryocytes. Blood 1967; 30: 54-61.
10. Yang M, Li K, Ng PC, et al. Promoting effects of serotonin on hematopoiesis: Ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis. Stem Cells 2007; 25: 1800-1806.
11. Yang M, Srikiatkhachorn A, Anthony M, et al. Serotonin stimulates megakaryocytopoiesis via the 5-HT2 receptor. Blood Coagul Fibrinolysis 1996; 7: 127-133.
12. Battinelli E, Loscalzo J,. Nitric oxide induces apoptosis in megakaryocytic cell lines. Blood 2000; 95: 3451-3459.
13. Italiano JE Jr, Lecine P, Shivdasani RA, et al. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol 1999; 147: 1299-1312.
14. Patel SR, Hartwig JH, Italiano JE Jr,. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest 2005; 115: 3348-54.
15. Cramer EM, Norol F, Guichard J, et al. Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand. Blood 1997; 89: 2336-2346.
16. Baatout S,. The importance of cytoskeleton proteins in megakaryocyte spreading and platelet formation. Blood Rev 1996; 10: 17-19.
17. Rojnuckarin P, Kaushansky K,. Actin reorganization and proplatelet formation in murine megakaryocytes: The role of protein kinase calpha. Blood 2001; 97: 154-161.
18. Day RM, Agyeman AS, Segel MJ, et al. Serotonin induces pulmonary artery smooth muscle cell migration. Biochem Pharmacol 2006; 71: 386-397.
19. Matsusaka S, Wakabayashi I,. 5-Hydroxytryptamine as a potent migration enhancer of human aortic endothelial cells. FEBS Lett 2005; 579: 6721-6725.
20. Kushnir-Sukhov NM, Gilfillan AM, Coleman JW, et al. 5-hydroxytryptamine induces mast cell adhesion and migration. J Immunol 2006; 177: 6422-6432.
21. Liu Y, Suzuki YJ, Day RM, et al. Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circ Res 2004; 95: 579-586.
22. Buscemi N, Vandermeer B, Hooton N, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med 2005; 20: 1151-1158.
23. Buscemi N, Vandermeer B, Hooton N, et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction:meta-analysis. Bmj 2006; 332: 385-393.
24. Conti A, Conconi S, Hertens E,. Evidence for melatonin synthesis in mouse and human bone marrow cells. J Pineal Res 2000; 28: 193-202.
25. Lissoni P, Tancini G, Barni S, et al. The pineal hormone melatonin in hematology and its potential efficacy in the treatment of thrombocytopenia. Recenti Prog Med 1996; 87: 582-585.
26. Lissoni P, Barni S, Brivio F, et al. Treatment of cancer-related thrombocytopenia by low-dose subcutaneous interleukin-2 plus the pineal hormone melatonin: A biological phase II study. J Biol Regul Homeost Agents 1995; 9: 52-54.
27. Lissoni P, Tancini G, Barni S, et al. Treatment of cancer chemotherapy-induced toxicity with the pineal hormone melatonin. Support Care Cancer 1997; 5: 126-129.
28. Ye JY, Chan GC, Qiao L, et al. Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway. Haematologica 2010; 95: 1745-1753.
29. Yang M, Li K, Chui CM, et al. Expression of interleukin (IL) 1 type I and type II receptors in megakaryocytic cells and enhancing effects of IL-1beta on megakaryocytopoiesis and NF-E2 expression. Br J Haematol 2000; 111: 371-380.
30. Yang M, Chesterman CN, Chong BH,. Recombinant PDGF enhances megakaryocytopoiesis in vitro. Br J Haematol 1995; 91: 285-289.
31. Currao M, Balduini CL, Balduini A,. High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes. PLoS One 2013; 8: e54723.
32. Yang M, Chan GC, Deng R, et al. An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis. J Ethnopharmacol 2009; 124: 87-97.
33. Collet C, Schiltz C, Geoffroy V, et al. The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation. Faseb J 2008; 22: 418-427.
34. Tharayil VS, Wouters MM, Stanich JE, et al. Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. Neurogastroenterol Motil 2010; 22: 462-9, e109-e110.
35. Nebigil CG, Etienne N, Messaddeq N, et al. Serotonin is a novel survival factor of cardiomyocytes:mitochondria as a target of 5-HT2B receptor signaling. Faseb J 2003; 17: 1373-1375.
36. Nebigil CG, Launay JM, Hickel P, et al. 5-hydroxytryptamine 2B receptor regulates cell-cycle progression: Cross-talk with tyrosine kinase pathways. Proc Natl Acad Sci U S A 2000; 97: 2591-2596.
37. Todisco M,. Melatonin makes splenectomy unnecessary in two patients with idiopathic thrombocytopenic purpura refractory to corticosteroids. J Pineal Res 2007; 43: 214.
38. Todisco M, Casaccia P, Rossi N,. Severe bleeding symptoms in refractory idiopathic thrombocytopenic purpura: A case successfully treated with melatonin. Am J Ther 2003; 10: 135-136.
39. Todisco M, Rossi N,. Melatonin for refractory idiopathic thrombocytopenic purpura: A report of 3 cases. Am J Ther 2002; 9: 524-526.