Minimally invasive convection-enhanced delivery of biologics into dorsal root ganglia: Validation in the pig model and prospective modeling in humans

Journal of Neurosurgery

Volumn 121, Issue 4, 2014, Pages 851-858

  Pleticha, Josef ^a   Maus, Timothy P ^a   Christner, Jodie A ^a   Marsh, Michael P ^a   Lee, Kendall H ^a   Hooten, W Michael ^a   Beutler, Andreas S ^a  

^a MAYO CLINIC   (United States)

Author keywords

Computed tomography; Convection enhanced delivery; Dorsal root ganglia; Gene therapy; Intraganglionic injection; Pain; Peripheral nerve

Indexed keywords

AGAROSE; PARVOVIRUS VECTOR; BIOLOGICAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CADAVER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CONVECTION ENHANCED DELIVERY; DRUG DELIVERY SYSTEM; DURA MATER; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; MEASUREMENT ACCURACY; MINIMALLY INVASIVE PROCEDURE; MYELOGRAPHY; NEEDLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PORCINE MODEL; PROSPECTIVE STUDY; PUNCTURE; SPINAL CORD NERVE CELL; SPINAL GANGLION; THERMODYNAMICS; TRANSGENE; VALIDATION STUDY; ANIMAL; ANIMAL MODEL; INJECTION; PROCEDURES; SWINE;

ANIMALS; BIOLOGICAL PRODUCTS; CONVECTION; GANGLIA, SPINAL; HUMANS; INJECTIONS; MODELS, ANIMAL; SUS SCROFA; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84907882512     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2014.6.JNS132364     Document Type: Article

References (21)

1. Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, et al: Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs. Toxicol Sci 91: 286-298, 2006
2. Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH: Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci U S A 91: 2076-2080, 1994
3. Bogduk N, International Spine Intervention Society (eds): Practice Guidelines for Spinal Diagnostic and Treatment Procedures. San Francisco: International Spine Intervention Society, 2004
4. Federici T, Taub JS, Baum GR, Gray SJ, Grieger JC, Matthews KA, et al: Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs. Gene Ther 19: 852-859, 2012
5. Fischer G, Kostic S, Nakai H, Park F, Sapunar D, Yu H, et al: Direct injection into the dorsal root ganglion: Technical, behavioral, and histological observations. J Neurosci Methods 199: 43-55, 2011
6. Geurts JW, van Wijk RM, Stolker RJ, Groen GJ: Efficacy of radiofrequency procedures for the treatment of spinal pain: A systematic review of randomized clinical trials. Reg Anesth Pain Med 26: 394-400, 2001
7. Gray SJ, Nagabhushan Kalburgi S, McCown TJ, Jude Samulski R: Global CNS gene delivery and evasion of anti-AAVneutralizing antibodies by intrathecal AAV administration in non-human primates. Gene Ther 20: 450-459, 2013
8. Jacques SJ, Ahmed Z, Forbes A, Douglas MR, Vigenswara V, Berry M, et al: AAV8(gfp) preferentially targets large diameter dorsal root ganglion neurones after both intra-dorsal root ganglion and intrathecal injection. Mol Cell Neurosci 49: 464-474, 2012
9. Karai L, Brown DC, Mannes AJ, Connelly ST, Brown J, Gandal M, et al: Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control. J Clin Invest 113: 1344-1352, 2004
10. Krauze MT, Saito R, Noble C, Tamas M, Bringas J, Park JW, et al: Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents. Technical note. J Neurosurg 103: 923-929, 2005
11. MacVicar J, King W, Landers MH, Bogduk N: The effectiveness of lumbar transforaminal injection of steroids: A comprehensive review with systematic analysis of the published data. Pain Med 14: 14-28, 2013
12. National Research Council: Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press, 1996
13. Pleticha J, Maus TP, Jeng-Singh C, Marsh MP, Al-Saiegh F, Christner JA, et al: Pig lumbar spine anatomy and imagingguided lateral lumbar puncture: A new large animal model for intrathecal drug delivery. J Neurosci Methods 216: 10-15, 2013
14. Puljak L, Kojundzic SL, Hogan QH, Sapunar D: Targeted delivery of pharmacological agents into rat dorsal root ganglion. J Neurosci Methods 177: 397-402, 2009
15. Ratliff JK, Oldfield EH: Convection-enhanced delivery in intact and lesioned peripheral nerve. J Neurosurg 95: 1001-1011, 2001
16. Rosenbluth KH, Luz M, Mohr E, Mittermeyer S, Bringas J, Bankiewicz KS: Design of an in-dwelling cannula for convection-enhanced delivery. J Neurosci Methods 196: 118-123, 2011
17. Storek B, Harder NM, Banck MS, Wang C, McCarty DM, Janssen WG, et al: Intrathecal long-Term gene expression by self-complementary adeno-Associated virus type 1 suitable for chronic pain studies in rats. Mol Pain 2: 4, 2006
18. Storek B, Reinhardt M, Wang C, Janssen WGM, Harder NM, Banck MS, et al: Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain. Proc Natl Acad Sci U S A 105: 1055-1060, 2008
19. Wald JT, Maus TP, Geske JR, Carter RE, Diehn FE, Kaufmann TJ, et al: Safety and efficacy of CT-guided transforaminal cervical epidural steroid injections using a posterior approach. AJNR Am J Neuroradiol 33: 415-419, 2012
20. Yin D, Forsayeth J, Bankiewicz KS: Optimized cannula design and placement for convection-enhanced delivery in rat striatum. J Neurosci Methods 187: 46-51, 2010
21. Yu H, Fischer G, Ferhatovic L, Fan F, Light AR, Weihrauch D, et al: Intraganglionic AAV6 results in efficient and long-Term gene transfer to peripheral sensory nervous system in adult rats. PLoS ONE 8: E61266, 2013