Human iPSC-derived miniature organs: A tool for drug studies

Clinical Pharmacology and Therapeutics

Volumn 96, Issue 3, 2014, Pages 310-313

  Takebe, T ^a,b   Taniguchi, H ^a  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL COMMUNICATION; DEVELOPMENTAL BIOLOGY; DRUG INDUSTRY; EMBRYO DEVELOPMENT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; STEM CELL CULTURE;

CELL CULTURE TECHNIQUES; CELLS, CULTURED; DRUG DISCOVERY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; ORGANOGENESIS; TISSUE ENGINEERING; TOXICITY TESTS;

EID: 84907876008     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2014.110     Document Type: Article

References (5)

1. Takebe, T. et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499, 481-484 (2013).
2. Takebe, T. et al. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat. Protoc. 9, 396-409 (2014).
3. Lancaster, M.A. et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373-379 (2013).
4. Sato, T. & Clevers, H. Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications. Science 340, 1190-1194 (2013).
5. Taguchi, A. et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14, 53-67 (2014).