Anti-interleukin-6 receptor antibody (MR16-1) promotes muscle regeneration via modulation of gene expressions in infiltrated macrophages

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 10, 2014, Pages 3170-3180

  Fujita, Ryo ^a   Kawano, Fumimori ^a   Ohira, Takashi ^b   Nakai, Naoya ^a   Shibaguchi, Tsubasa ^b   Nishimoto, Norihiro ^c   Ohira, Yoshinobu ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Anti mouse IL 6 receptor (IL 6R) antibody; Fibrosis; Muscle injury; Muscle regeneration

Indexed keywords

ANTIINFLAMMATORY AGENT; ARGINASE; INTERLEUKIN 10; INTERLEUKIN 6 RECEPTOR; MR 16 1; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARGINASE GENE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG MECHANISM; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; MACROPHAGE; MALE; MOUSE; MUSCLE INJURY; MUSCLE MASS; MUSCLE REGENERATION; NONHUMAN; NTERLEUKIN 10 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTI-MOUSE IL-6 RECEPTOR (IL-6R) ANTIBODY; FIBROSIS; MUSCLE INJURY; MUSCLE REGENERATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ARGINASE; GENE EXPRESSION REGULATION; INTERLEUKIN-10; MACROPHAGES; MICE; MICE, KNOCKOUT; MUSCLE PROTEINS; MUSCLE, SKELETAL; RATS; RECEPTORS, INTERLEUKIN-6; REGENERATION;

EID: 84907870526     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.01.014     Document Type: Article

References (43)

1. S.B. Charge, and M.A. Rudnicki Cellular and molecular regulation of muscle regeneration Physiol. Rev. 84 2004 209 238
2. S. Ciciliot, and S. Schiaffino Regeneration of mammalian skeletal muscle. Basic mechanisms and clinical implications Curr. Pharm. Des. 16 2010 906 914
3. J.G. Tidball Inflammatory processes in muscle injury and repair Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 2005 R345 R353
4. J.G. Tidball, and S.A. Villalta Regulatory interactions between muscle and the immune system during muscle regeneration Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 2010 R1173 R1187
5. L. Pelosi, C. Giacinti, C. Nardis, G. Borsellino, E. Rizzuto, C. Nicoletti, F. Wannenes, L. Battistini, N. Rosenthal, M. Molinaro, and A. Musaro Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines FASEB J. 21 2007 1393 1402
6. K. Sato, Y. Li, W. Foster, K. Fukushima, N. Badlani, N. Adachi, A. Usas, F.H. Fu, and J. Huard Improvement of muscle healing through enhancement of muscle regeneration and prevention of fibrosis Muscle Nerve 28 2003 365 372
7. M. Segawa, S. Fukada, Y. Yamamoto, H. Yahagi, M. Kanematsu, M. Sato, T. Ito, A. Uezumi, S. Hayashi, Y. Miyagoe-Suzuki, S. Takeda, K. Tsujikawa, and H. Yamamoto Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis Exp. Cell Res. 314 2008 3232 3244
8. N. Dumont, P. Bouchard, and J. Frenette Neutrophil-induced skeletal muscle damage: a calculated and controlled response following hindlimb unloading and reloading Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 2008 R1831 R1838
9. L. Arnold, A. Henry, F. Poron, Y. Baba-Amer, N. van Rooijen, A. Plonquet, R.K. Gherardi, and B. Chazaud Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis J. Exp. Med. 204 2007 1057 1069
10. N. Dumont, and J. Frenette Macrophages protect against muscle atrophy and promote muscle recovery in vivo and in vitro: a mechanism partly dependent on the insulin-like growth factor-1 signaling molecule Am. J. Pathol. 176 2010 2228 2235
11. J.G. Tidball, and M. Wehling-Henricks Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo J. Physiol. 578 2007 327 336
12. S.A. Villalta, H.X. Nguyen, B. Deng, T. Gotoh, and J.G. Tidball Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy Hum. Mol. Genet. 18 2009 482 496
13. S. Gordon, and F.O. Martinez Alternative activation of macrophages: mechanism and functions Immunity 32 2010 593 604
14. S. Gordon, and P.R. Taylor Monocyte and macrophage heterogeneity Nat. Rev. Immunol. 5 2005 953 964
15. R.D. Stout, C. Jiang, B. Matta, I. Tietzel, S.K. Watkins, and J. Suttles Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences J. Immunol. 175 2005 342 349
16. D. Ruffell, F. Mourkioti, A. Gambardella, P. Kirstetter, R.G. Lopez, N. Rosenthal, and C. Nerlov A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair Proc. Natl. Acad. Sci. U. S. A. 106 2009 17475 17480
17. S.E. Chen, E. Gerken, Y. Zhang, M. Zhan, R.K. Mohan, A.S. Li, M.B. Reid, and Y.P. Li Role of TNF-{alpha} signaling in regeneration of cardiotoxin-injured muscle Am. J. Physiol. Cell Physiol. 289 2005 C1179 C1187
18. S.E. Chen, B. Jin, and Y.P. Li TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK Am. J. Physiol. Cell Physiol. 292 2007 C1660 C1671
19. M. Cheng, M.H. Nguyen, G. Fantuzzi, and T.J. Koh Endogenous interferon-gamma is required for efficient skeletal muscle regeneration Am. J. Physiol. Cell Physiol. 294 2008 C1183 C1191
20. F. Haddad, F. Zaldivar, D.M. Cooper, and G.R. Adams IL-6-induced skeletal muscle atrophy J. Appl. Physiol. 98 2005 911 917
21. A.L. Serrano, B. Baeza-Raja, E. Perdiguero, M. Jardi, and P. Munoz-Canoves Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy Cell Metab. 7 2008 33 44
22. T. Tsujinaka, J. Fujita, C. Ebisui, M. Yano, E. Kominami, K. Suzuki, K. Tanaka, A. Katsume, Y. Ohsugi, H. Shiozaki, and M. Monden Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice J. Clin. Invest. 97 1996 244 249
23. T. Tsujinaka, M. Kishibuchi, M. Yano, T. Morimoto, C. Ebisui, J. Fujita, A. Ogawa, H. Shiozaki, E. Kominami, and M. Monden Involvement of interleukin-6 in activation of lysosomal cathepsin and atrophy of muscle fibers induced by intramuscular injection of turpentine oil in mice J. Biochem. 122 1997 595 600
24. S. Acharyya, S.M. Sharma, A.S. Cheng, K.J. Ladner, W. He, W. Kline, H. Wang, M.C. Ostrowski, T.H. Huang, and D.C. Guttridge TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in Duchenne muscular dystrophy PLoS One 5 2010
25. M.D. Grounds, H.G. Radley, B.L. Gebski, M.A. Bogoyevitch, and T. Shavlakadze Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle Clin. Exp. Pharmacol. Physiol. 35 2008 846 851
26. M.D. Grounds, and J. Torrisi Anti-TNFalpha (Remicade) therapy protects dystrophic skeletal muscle from necrosis FASEB J. 18 2004 676 682
27. T. Kishimoto, T. Taga, and S. Akira Cytokine signal transduction Cell 76 1994 253 262
28. N. Nishimoto, and T. Kishimoto Inhibition of IL-6 for the treatment of inflammatory diseases Curr. Opin. Pharmacol. 4 2004 386 391
29. M. Mukaino, M. Nakamura, O. Yamada, S. Okada, S. Morikawa, F. Renault-Mihara, A. Iwanami, T. Ikegami, Y. Ohsugi, O. Tsuji, H. Katoh, Y. Matsuzaki, Y. Toyama, M. Liu, and H. Okano Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation Exp. Neurol. 224 2010 403 414
30. N. Nishimoto, K. Yoshizaki, N. Miyasaka, K. Yamamoto, S. Kawai, T. Takeuchi, J. Hashimoto, J. Azuma, and T. Kishimoto Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial Arthritis Rheum. 50 2004 1761 1769
31. S. Okada, M. Nakamura, Y. Mikami, T. Shimazaki, M. Mihara, Y. Ohsugi, Y. Iwamoto, K. Yoshizaki, T. Kishimoto, Y. Toyama, and H. Okano Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury J. Neurosci. Res. 76 2004 265 276
32. M. Okazaki, Y. Yamada, N. Nishimoto, K. Yoshizaki, and M. Mihara Characterization of anti-mouse interleukin-6 receptor antibody Immunol. Lett. 84 2002 231 240
33. N. Takagi, M. Mihara, Y. Moriya, N. Nishimoto, K. Yoshizaki, T. Kishimoto, Y. Takeda, and Y. Ohsugi Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis Arthritis Rheum. 41 1998 2117 2121
34. B.R. McKay, M. De Lisio, A.P. Johnston, C.E. O'Reilly, S.M. Phillips, M.A. Tarnopolsky, and G. Parise Association of interleukin-6 signalling with the muscle stem cell response following muscle-lengthening contractions in humans PLoS One 4 2009 e6027
35. K. Kami, and E. Senba In vivo activation of STAT3 signaling in satellite cells and myofibers in regenerating rat skeletal muscles J. Histochem. Cytochem. 50 2002 1579 1589
36. N. Okiyama, T. Sugihara, Y. Iwakura, H. Yokozeki, N. Miyasaka, and H. Kohsaka Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A Arthritis Rheum. 60 2009 2505 2512
37. K. Wakabayashi, M. Fujioka, S. Kanzaki, H.J. Okano, S. Shibata, D. Yamashita, M. Masuda, M. Mihara, Y. Ohsugi, K. Ogawa, and H. Okano Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea Neurosci. Res. 66 2010 345 352
38. M. Wehling-Henricks, M.C. Jordan, T. Gotoh, W.W. Grody, K.P. Roos, and J.G. Tidball Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy PLoS One 5 2010 e10763
39. B. Vidal, A.L. Serrano, M. Tjwa, M. Suelves, E. Ardite, R. De Mori, B. Baeza-Raja, M. Martinez de Lagran, P. Lafuste, V. Ruiz-Bonilla, M. Jardi, R. Gherardi, C. Christov, M. Dierssen, P. Carmeliet, J.L. Degen, M. Dewerchin, and P. Munoz-Canoves Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway Genes Dev. 22 2008 1747 1752
40. M. Kobara, K. Noda, M. Kitamura, A. Okamoto, T. Shiraishi, H. Toba, H. Matsubara, and T. Nakata Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice Cardiovasc. Res. 87 2010 424 430
41. T.X. Xie, D. Wei, M. Liu, A.C. Gao, F. Ali-Osman, R. Sawaya, and S. Huang Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis Oncogene 23 2004 3550 3560
42. D. Sun, C.O. Martinez, O. Ochoa, L. Ruiz-Willhite, J.R. Bonilla, V.E. Centonze, L.L. Waite, J.E. Michalek, L.M. McManus, and P.K. Shireman Bone marrow-derived cell regulation of skeletal muscle regeneration FASEB J. 23 2009 382 395
43. K. Kami, Y. Morikawa, M. Sekimoto, and E. Senba Gene expression of receptors for IL-6, LIF, and CNTF in regenerating skeletal muscles J. Histochem. Cytochem. 48 2000 1203 1213