UCP1 is present in porcine adipose tissue and is responsive to postnatal leptin

Journal of Endocrinology

Volumn 223, Issue 1, 2014, Pages M31-M38

  Mostyn, Alison ^b   Attig, Linda ^a   Larcher, Thibaut ^c   Dou, Samir ^a   Chavatte Palmer, Pascale ^d   Boukthir, Monia ^e   Gertler, Arieh ^f   Djiane, Jean ^g   Symonds, Michael E ^h   Abdennebi Najar, Latifa ^a  

^a INSTITUT POLYTECHNIQUE LASALLE BEAUVAIS   (France)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c INRA UMR 703   (France)

^d INRA Institut National de la Recherche Agronomique   (France)

^e UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

^f HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^g CEMAGREF   (France)

^h NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Adipose tissue; IUGR; Leptin; Porcine; Programming; UCP1

Indexed keywords

LEPTIN; SODIUM CHLORIDE; UNCOUPLING PROTEIN 1; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH WEIGHT; BODY TEMPERATURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTRAUTERINE GROWTH RETARDATION; NEWBORN; NONHUMAN; NONSHIVERING THERMOGENESIS; PERINATAL DEVELOPMENT; PIGLET; PROGENY; SWINE; THERMOGENESIS; THERMOREGULATION; TREATMENT RESPONSE; ADIPOSE TISSUE; ANIMAL; BROWN ADIPOSE TISSUE; DRUG ADMINISTRATION; DRUG EFFECTS; INTRAMUSCULAR DRUG ADMINISTRATION; METABOLISM; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; ANIMALS, NEWBORN; BODY TEMPERATURE; DRUG ADMINISTRATION SCHEDULE; FEMALE; FETAL GROWTH RETARDATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAMUSCULAR; ION CHANNELS; LEPTIN; MITOCHONDRIAL PROTEINS; SWINE; THERMOGENESIS;

EID: 84907865026     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-14-0155     Document Type: Article

References (27)

1. Attig L, Djiane J, Gertler A, Rampin O, Larcher T, Boukthir S, Anton PM, Madec JY, Gourdou I&Abdennebi-Najar L 2008 Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development. American Journal of Physiology Endocrinology and Metabolism 295 E1117-E1125. (doi:10.1152/ajpendo.90542.2008)
2. Attig L, Brisard D, Larcher T, Mickiewicz M, Guilloteau P, Boukthir S, Niamba CN, Gertler A, Djiane J, Monniaux D et al. 2013 Postnatal leptin promotes organ maturation and development in IUGR piglets. PLoS ONE 8 e64616. (doi:10.1371/journal.pone.0064616)
3. Berg F, Gustafson U&Andersson L 2006 The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor thermoregulation in piglets. PLoS Genetics 2 e129. (doi:10.1371/journal.pgen.0020129)
4. Blat S, Morise A, Sauret A, Louveau I, Mace K, Le Huerou-Luron I&Seve B 2012 The protein level of isoenergetic formulae does not modulate postprandial insulin secretion in piglets and has no consequences on later glucose tolerance. British Journal of Nutrition 108 102-112. (doi:10.1017/S0007114511005253)
5. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 248-254. (doi:10.1016/0003-2697(76)90527-3)
6. Budge H, Bispham J, Dandrea J, Evans L, Heasman L, Ingleton P, Sullivan C, Wilson V, Stephenson T & Symonds ME 2000 Effect ofmaternal nutrition on brown adipose tissue and prolactin receptor status in the fetal lamb. Pediatric Research 47781-786. (doi:10.1203/00006450-200006000-00017)
7. Campbell RG&Dunkin AC 1982 The effects of birth weight and level of feeding in early life on growth and development of muscle and adipose tissue in the young pig. Animal Production 35 185-192. (doi:10.1017/S0003356100027343)
8. Clarke L, Heasman L, Firth K&Symonds ME 1997 Influence of route of delivery and ambient temperature on thermoregulation in newborn lambs. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 272 R1931-R1939.
9. Darby CJ, Clarke L, Lomax MA&Symonds ME 1996 Brown adipose tissue and liver development during early postnatal life in hand-reared and ewe-reared lambs. Reproduction Fertility and Development 8 137-145. (doi:10.1071/RD9960137)
10. Guilloteau P, Zabielski R, Hammon HM&Metges CC 2010 Nutritional programming of gastrointestinal tract development. Is the pig a good model for man? Nutrition Research Reviews 23 4-22. (doi:10.1017/S0954422410000077)
11. Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-Medina M, Patti ME & Bianco AC 2010 Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology 151 4573-4582. (doi:10.1210/en.2010-0511)
12. Jespersen NZ, Larsen TJ, Peijs L, Daugaard S, Homoe P, Loft A, de Jong J, Mathur N, Cannon B, Nedergaard J et al. 2013 A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metabolism 17 798-805. (doi:10.1016/j.cmet.2013.04.011)
13. Misra PK, Tiwari DK, Sharma B&Kaul R 1984 Free fatty acids and triglycerides in normoglycemic low birth weight newborns in early neonatal period. Indian Journal of Pediatrics 51 637-641. (doi:10.1007/BF02776378)
14. Mostyn A, Keisler DH, Webb R, Stephenson T&Symonds ME 2001 The role of leptin in the transition from fetus to neonate. Proceedings of the Nutrition Society 60 187-194. (doi:10.1079/PNS200086)
15. Mostyn A, Bispham J, Pearce S, Evens Y, Raver N, Keisler DH, Webb R, Stephenson T&Symonds ME 2002 Differential effects of leptin on thermoregulation and uncoupling protein abundance in the neonatal lamb. FASEB Journal 16 1438-1440. (doi:10.1096/fj.02-0077fje)
16. Mostyn A, Pearce S, Budge H, Elmes M, Forhead AJ, Fowden AL, Stephenson T&Symonds ME 2003 Influence of cortisol on adipose tissue development in the fetal sheep during late gestation. Journal of Endocrinology 176 23-30. (doi:10.1677/joe.0.1760023)
17. Nedergaard J&Cannon B 2013 UCP1 mRNA does not produce heat. Biochemica et Biophysica Acta 1831 943-949. (doi:10.1016/j.bbalip.2013.01.009)
18. Nedergaard J, Connolly E&Cannon B 1986 Brown adipose tissue in the mammalian neonate. In Brown Adipose Tissue, pp 152-213. Eds P Trayhurn&D Nicholls. London: Edward Arnold
19. Pope M, Budge H&Symonds ME 2014 The developmental transition of ovine adipose tissue through early life. Acta Physiologica 210 20-30. (doi:10.1111/apha.12053)
20. Schermer SJ, Bird JA, Lomax MA, Shepherd DA&Symonds ME 1996 Effect of fetal thyroidectomy on brown adipose tissue and thermoregulation in newborn lambs. Reproduction Fertility and Development 8 995-1002. (doi:10.1071/RD9960995)
21. Skilton MR 2008 Intrauterine risk factors for precocious atherosclerosis. Pediatrics 121 570-574. (doi:10.1542/peds.2007-1801)
22. Symonds ME 2013 Brown adipose tissue growth and development. Scientifica 2013 305763. (doi:10.1155/2013/305763)
23. Symonds ME&Lomax MA 1992 Maternal and environmental influences on thermoregulation in the neonate. Proceedings of the Nutrition Society 51 165-172. (doi:10.1079/PNS19920026)
24. Symonds ME, Andrews DC&Johnson PJ 1989 The control of thermoregulation in the developing lamb during slow wave sleep. Journal of Developmental Physiology 11 289-298.
25. Symonds ME, Bird JA, Sullivan C, Wilson V, Clarke L&Stephenson T 2000 Effect of delivery temperature on endocrine stimulation of thermoregulation in lambs born by cesarean section. Journal of Applied Physiology 88 47-53.
26. Trayhurn P, Temple NJ&Van Aerde J 1989 Evidence from immunoblotting studies on uncoupling protein that brown adipose tissue is not present in the domestic pig. Canadian Journal of Physiology and Pharmacology 67 1480-1485. (doi:10.1139/y89-239)
27. Wu J, Cohen P&Spiegelman BM 2013 Adaptive thermogenesis in adipocytes: is beige the new brown? Genes and Development 27 234-250. (doi:10.1101/gad.211649.112)