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Volumn 5, Issue 10, 2014, Pages 1533-1539

Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity

(18) McCoull, William a Hennessy, Edward J a Blades, Kevin a Box, Matthew R a Chuaqui, Claudio a Dowling, James E a Davies, Christopher D a Ferguson, Andrew D a Goldberg, Frederick W a Howe, Nicholas J a Kemmitt, Paul D a Lamont, Gillian M a Madden, Katrina a McWhirter, Claire a Varnes, Jeffrey G a Ward, Richard A a Williams, Jason D a Yang, Bin a

a ASTRAZENECA (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 AZAINDOLE; FRAX 597; INDOLE DERIVATIVE; P21 ACTIVATED KINASE 1 INHIBITOR; PF 3758309; PHOSPHOTRANSFERASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; RNA TRANSLATION; STRUCTURE ACTIVITY RELATION; VALIDATION STUDY;

EID: 84907858621 PISSN: 20402503 EISSN: 20402511 Source Type: Journal
DOI: 10.1039/c4md00280f Document Type: Article

Times cited : (18)

References (20)

1
- 84890946972
- M. Radu G. Semenova R. Kosoff J. Chernoff Nat. Rev. Cancer 2014 14 13 25
- (2014) Nat. Rev. Cancer , vol.14 , pp. 13-25
- Radu, M.¹ Semenova, G.² Kosoff, R.³ Chernoff, J.⁴

2
- 84893820343
- H. King N. S. Nicholas C. M. Wells Int. Rev. Cell Mol. Biol. 2014 309 347 387
- (2014) Int. Rev. Cell Mol. Biol. , vol.309 , pp. 347-387
- King, H.¹ Nicholas, N.S.² Wells, C.M.³

3
- 33745684525
- R. Kumar A. E. Gururaj C. J. Barnes Nat. Rev. Cancer 2006 6 459 471
- (2006) Nat. Rev. Cancer , vol.6 , pp. 459-471
- Kumar, R.¹ Gururaj, A.E.² Barnes, C.J.³

4
- 79955568142
- C. C. Ong A. M. Jubb P. M. Haverty W. Zhou V. Tran T. Truong H. Turley T. O'Brien D. Vucic A. L. Harris M. Belvin L. S. Friedman E. M. Blackwood H. Koeppen K. P. Hoeflich Proc. Natl. Acad. Sci. U. S. A. 2011 108 7177 7182
- (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 7177-7182
- Ong, C.C.¹ Jubb, A.M.² Haverty, P.M.³ Zhou, W.⁴ Tran, V.⁵ Truong, T.⁶ Turley, H.⁷ O'Brien, T.⁸ Vucic, D.⁹ Harris, A.L.¹⁰ Belvin, M.¹¹ Friedman, L.S.¹² Blackwood, E.M.¹³ Koeppen, H.¹⁴ Hoeflich, K.P.¹⁵

5
- 84866503986
- C. W. Menges E. Sementino J. Talarchek J. Xu J. Chernoff J. R. Peterson J. R. Testa Mol. Cancer Res. 2012 10 1178 1188
- (2012) Mol. Cancer Res. , vol.10 , pp. 1178-1188
- Menges, C.W.¹ Sementino, E.² Talarchek, J.³ Xu, J.⁴ Chernoff, J.⁵ Peterson, J.R.⁶ Testa, J.R.⁷

6
- 77954216859
- C. Yi J. Maksimoska R. Marmorstein J. L. Kissil Biochem. Pharmacol. 2010 80 683 689
- (2010) Biochem. Pharmacol. , vol.80 , pp. 683-689
- Yi, C.¹ Maksimoska, J.² Marmorstein, R.³ Kissil, J.L.⁴

7
- 84858670884
- J. J. Crawford K. P. Hoeflich J. Rudolph Expert Opin. Ther. Pat. 2012 22 293 310
- (2012) Expert Opin. Ther. Pat. , vol.22 , pp. 293-310
- Crawford, J.J.¹ Hoeflich, K.P.² Rudolph, J.³

8
- 84879422749
- Y. Xu J. M. Foulks A. Clifford B. Brenning S. Lai B. Luo K. M. Parnell S. Merx M. V. McCullar S. B. Kanner K. Ho Bioorg. Med. Chem. Lett. 2013 23 4072 4075
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 4072-4075
- Xu, Y.¹ Foulks, J.M.² Clifford, A.³ Brenning, B.⁴ Lai, S.⁵ Luo, B.⁶ Parnell, K.M.⁷ Merx, S.⁸ McCullar, M.V.⁹ Kanner, S.B.¹⁰ Ho, K.¹¹

9
- 84894073762
- S. T. Staben J. A. Feng K. Lyle M. Belvin J. Boggs J. D. Burch C. Chua H. Cui A. G. DiPasquale L. S. Friedman C. Heise H. Koeppen A. Kotey R. Mintzer A. Oh D. A. Roberts L. Rouge J. Rudolph C. Tam W. Wang Y. Xiao A. Young Y. Zhang K. P. Hoeflich J. Med. Chem. 2014 57 1033 1045
- (2014) J. Med. Chem. , vol.57 , pp. 1033-1045
- Staben, S.T.¹ Feng, J.A.² Lyle, K.³ Belvin, M.⁴ Boggs, J.⁵ Burch, J.D.⁶ Chua, C.⁷ Cui, H.⁸ Dipasquale, A.G.⁹ Friedman, L.S.¹⁰ Heise, C.¹¹ Koeppen, H.¹² Kotey, A.¹³ Mintzer, R.¹⁴ Oh, A.¹⁵ Roberts, D.A.¹⁶ Rouge, L.¹⁷ Rudolph, J.¹⁸ Tam, C.¹⁹ Wang, W.²⁰ more..

10
- 84861510552
- C. Guo I. McAlpine J. Zhang D. D. Knighton S. Kephart M. C. Johnson H. Li D. Bouzida A. Yang L. Dong J. Marakovits J. Tikhe P. Richardson L. C. Guo R. Kania M. P. Edwards E. Kraynov J. Christensen J. Piraino J. Lee E. Dagostino C. Del-Carmen Y. Deng T. Smeal B. W. Murray J. Med. Chem. 2012 55 4728 4739
- (2012) J. Med. Chem. , vol.55 , pp. 4728-4739
- Guo, C.¹ McAlpine, I.² Zhang, J.³ Knighton, D.D.⁴ Kephart, S.⁵ Johnson, M.C.⁶ Li, H.⁷ Bouzida, D.⁸ Yang, A.⁹ Dong, L.¹⁰ Marakovits, J.¹¹ Tikhe, J.¹² Richardson, P.¹³ Guo, L.C.¹⁴ Kania, R.¹⁵ Edwards, M.P.¹⁶ Kraynov, E.¹⁷ Christensen, J.¹⁸ Piraino, J.¹⁹ Lee, J.²⁰ more..

11
- 84907807977
- B. W. Murray C. Guo J. Piraino J. K. Westwick C. Zhang J. Lamerdin E. Dagostino D. Knighton C. Loi M. Zager E. Kraynov I. Popoff J. G. Christensen R. Martinez S. E. Kephart J. Marakovits S. Karlicek S. Bergqvist T. Smeal Proc. Natl. Acad. Sci. U. S. A., Early Ed. 2010 1 6
- (2010) Proc. Natl. Acad. Sci. U. S. A., Early Ed. , pp. 1-6
- Murray, B.W.¹ Guo, C.² Piraino, J.³ Westwick, J.K.⁴ Zhang, C.⁵ Lamerdin, J.⁶ Dagostino, E.⁷ Knighton, D.⁸ Loi, C.⁹ Zager, M.¹⁰ Kraynov, E.¹¹ Popoff, I.¹² Christensen, J.G.¹³ Martinez, R.¹⁴ Kephart, S.E.¹⁵ Marakovits, J.¹⁶ Karlicek, S.¹⁷ Bergqvist, S.¹⁸ Smeal, T.¹⁹

12
- 84885117132
- S. Licciulli J. Maksimoska C. Zhou S. Troutman S. Kota Q. Liu S. Duron D. Campbell J. Chernoff J. Field R. Marmorstein J. L. Kissil J. Biol. Chem. 2013 288 29105 29114
- (2013) J. Biol. Chem. , vol.288 , pp. 29105-29114
- Licciulli, S.¹ Maksimoska, J.² Zhou, C.³ Troutman, S.⁴ Kota, S.⁵ Liu, Q.⁶ Duron, S.⁷ Campbell, D.⁸ Chernoff, J.⁹ Field, J.¹⁰ Marmorstein, R.¹¹ Kissil, J.L.¹²

13
- 84869225094
- H. Y. Chow A. M. Jubb J. N. Koch Z. M. Jaffer D. Stepanova D. A. Campbell S. G. Duron M. O'Farrell K. Q. Cai A. J. P. Klein-Szanto J. S. Gutkind K. P. Hoeflich J. Chernoff Cancer Res. 2012 72 5966 5975
- (2012) Cancer Res. , vol.72 , pp. 5966-5975
- Chow, H.Y.¹ Jubb, A.M.² Koch, J.N.³ Jaffer, Z.M.⁴ Stepanova, D.⁵ Campbell, D.A.⁶ Duron, S.G.⁷ O'Farrell, M.⁸ Cai, K.Q.⁹ Klein-Szanto, A.J.P.¹⁰ Gutkind, J.S.¹¹ Hoeflich, K.P.¹² Chernoff, J.¹³

14
- 36148943501
- P. P. Graczyk J. Med. Chem. 2007 50 5773 5779
- (2007) J. Med. Chem. , vol.50 , pp. 5773-5779
- Graczyk, P.P.¹

15
- 84868481873
- G. Bollag J. Tsai J. Zhang C. Zhang P. Ibrahim K. Nolop P. Hirth Nat. Rev. Drug Discovery 2012 11 873 886
- (2012) Nat. Rev. Drug Discovery , vol.11 , pp. 873-886
- Bollag, G.¹ Tsai, J.² Zhang, J.³ Zhang, C.⁴ Ibrahim, P.⁵ Nolop, K.⁶ Hirth, P.⁷

16
- 84886452695
- V. S. Goodfellow C. J. Loweth S. B. Ravula T. Wiemann T. Nguyen Y. Xu D. E. Todd D. Sheppard S. Pollack O. Polesskaya D. F. Marker S. Dewhurst H. A. Gelbard J. Med. Chem. 2013 56 8032 8048
- (2013) J. Med. Chem. , vol.56 , pp. 8032-8048
- Goodfellow, V.S.¹ Loweth, C.J.² Ravula, S.B.³ Wiemann, T.⁴ Nguyen, T.⁵ Xu, Y.⁶ Todd, D.E.⁷ Sheppard, D.⁸ Pollack, S.⁹ Polesskaya, O.¹⁰ Marker, D.F.¹¹ Dewhurst, S.¹² Gelbard, H.A.¹³

17
- 84862285959
- R. A. Norman A. Schott D. M. Andrews J. Breed K. M. Foote A. P. Garner D. Ogg J. P. Orme J. H. Pink K. Roberts D. A. Rudge A. P. Thomas A. G. Leach J. Med. Chem. 2012 55 5003 5012
- (2012) J. Med. Chem. , vol.55 , pp. 5003-5012
- Norman, R.A.¹ Schott, A.² Andrews, D.M.³ Breed, J.⁴ Foote, K.M.⁵ Garner, A.P.⁶ Ogg, D.⁷ Orme, J.P.⁸ Pink, J.H.⁹ Roberts, K.¹⁰ Rudge, D.A.¹¹ Thomas, A.P.¹² Leach, A.G.¹³

18
- 84897379530
- B. Over P. McCarren P. Artursson M. Foley F. Giordanetto G. Groenberg C. Hilgendorf M. D. Lee P. Matsson G. Muncipinto M. Pellisson M. W. D. Perry R. Svensson J. R. Duvall J. Kihlberg J. Med. Chem. 2014 57 2746 2754
- (2014) J. Med. Chem. , vol.57 , pp. 2746-2754
- Over, B.¹ McCarren, P.² Artursson, P.³ Foley, M.⁴ Giordanetto, F.⁵ Groenberg, G.⁶ Hilgendorf, C.⁷ Lee, M.D.⁸ Matsson, P.⁹ Muncipinto, G.¹⁰ Pellisson, M.¹¹ Perry, M.W.D.¹² Svensson, R.¹³ Duvall, J.R.¹⁴ Kihlberg, J.¹⁵

19
- 77953193637
- A. C. Cheng J. Eksterowicz S. Geuns-Meyer Y. Sun J. Med. Chem. 2010 53 4502 4510
- (2010) J. Med. Chem. , vol.53 , pp. 4502-4510
- Cheng, A.C.¹ Eksterowicz, J.² Geuns-Meyer, S.³ Sun, Y.⁴

20
- 84875733618
- A. B. Northrup M. H. Katcher M. D. Altman M. Chenard M. H. Daniels S. V. Deshmukh D. Falcone D. J. Guerin H. Hatch C. Li W. Lu B. Lutterbach T. J. Allison S. B. Patel J. F. Reilly M. Reutershan K. W. Rickert C. Rosenstein S. M. Soisson A. A. Szewczak D. Walker K. Wilson J. R. Young B. Pan C. J. Dinsmore J. Med. Chem. 2013 56 2294 2310
- (2013) J. Med. Chem. , vol.56 , pp. 2294-2310
- Northrup, A.B.¹ Katcher, M.H.² Altman, M.D.³ Chenard, M.⁴ Daniels, M.H.⁵ Deshmukh, S.V.⁶ Falcone, D.⁷ Guerin, D.J.⁸ Hatch, H.⁹ Li, C.¹⁰ Lu, W.¹¹ Lutterbach, B.¹² Allison, T.J.¹³ Patel, S.B.¹⁴ Reilly, J.F.¹⁵ Reutershan, M.¹⁶ Rickert, K.W.¹⁷ Rosenstein, C.¹⁸ Soisson, S.M.¹⁹ Szewczak, A.A.²⁰ more..

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