Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6

European Journal of Immunology

Volumn 44, Issue 9, 2014, Pages 2571-2576

  Riãno, Felipe ^a   Karunakaran, Mohindar M ^a   Starick, Lisa ^a   Li, Jianqiang ^a,d   Scholz, Claus J ^a   Kunzmann, Volker ^a   Olive, Daniel ^b   Amslinger, Sabine ^c   Herrmann, Thomas ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b INSERM   (France)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Antigen presentation processing; Antigen receptors; T cells; TCR; T cell

Indexed keywords

BTN3A1 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; TERPENE;

ANIMAL; ANTIGEN PRESENTATION/PROCESSING; ANTIGEN RECEPTORS; ARTICLE; CHO CELL LINE; CHROMOSOME 6; CRICETULUS; GENETIC TRANSDUCTION; GENETICS; HAMSTER; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PHOSPHORYLATION; T LYMPHOCYTE; TCR; ΓΔ T CELL;

ANTIGEN PRESENTATION/PROCESSING; ANTIGEN RECEPTORS; T CELLS; TCR; ΓΔ T CELL;

ANIMALS; ANTIGENS, CD; CHO CELLS; CHROMOSOMES, HUMAN, PAIR 6; CRICETINAE; CRICETULUS; HUMANS; LYMPHOCYTE ACTIVATION; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; TERPENES; TRANSDUCTION, GENETIC;

EID: 84907853347     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444712     Document Type: Article

References (20)

1. Davey, M. S., Tyrrell, J. M., Howe, R. A., Walsh, T. R., Moser, B., Toleman, M. A. and Eberl, M., Microbial isoprenoid biosynthesis and human γδ T cell activation. FEBS Lett. 2003. 544: 4-10.
2. Gober, H. J., Kistowska, M., Angman, L., Jenö, P., Mori, L. and De Libero, G., Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. J. Exp. Med. 2003. 197: 163-168
3. Li, J., Herold, M. J., Kimmel, B., Müller, I., Rincon-Orozco, B., Kunzmann, V. and Herrmann, T., Human T-cell receptor gammadelta cells recognize endogenousmevalonate metabolites in tumor cells. J. Immunol. 2009. 182: 8118-8124.
4. Kunzmann, V., Bauer, E., Feurle, J., Weissinger, F., Tony, H. P. and Wilhelm, M., Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity inmultiplemyeloma. Blood 2000. 96: 384-392.
5. Thompson, K., Rojas-Navea, J. and Rogers, M. J., Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. Blood 2006. 107: 651-654.
6. Li, J., Modulating the expression of enzymes of Isoprenoid synthesis: effects on Vγ9Vδ2 T cell activation and tumor cell growth. PhD Thesis, Graduate School of Life Sciences, Julius-Maximilians Universität Würzburg, 2009.
7. Morita, C. T., Jin, C., Sarikonda, G. and Wang, H., Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol. Rev. 2007. 215: 59-76.
8. Harly, C., Guillaume, Y., Nedellec, S., Peigné , C. M., Mönkkönen, H., Mönkkönen, J., Li, J. et al., Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. Blood 2012. 120: 2269-2279.
9. Palakodeti, A., Sandstrom, A., Sundaresan, L., Harly, C., Nedellec, S., Olive, D., Scotet, E. et al., The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. J. Biol. Chem. 2012. 287: 32780-32790.
10. Sandstrom, A., Peigné, C. M., Léger, A., Crooks, J. E., Konczak, F., Gesnel, M. C., Breathnach, R. et al., The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells. Immunity 2014. 40: 490-500.
11. Wang, H., Henry, O., Distefano, M. D., Wang, Y. C., Räikkönen, J., Mönkkönen, J., Tanaka, Y. et al., Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human V?2Vd2 T cells. J. Immunol. 2013. 191: 1029-1042.
12. Vavassori, S., Kumar, A., Wan, G. S., Ramanjaneyulu, G. S., Cavallari, M., El Daker, S., Beddoe, T. et al., Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. Nat. Immunol. 2013. 14: 908-916.
13. Karunakaran, M. M., Göbel, T. W., Starick, L., Walter, L. and Herrmann, T., Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos). Immunogenetics 2014. 66: 243-254.
14. Kistowska, M., Antigen recognition and thymic maturation of human TCR Vgamma9-Vdelta2 cells. PhD Thesis, Faculty of Science, University of Basel, 2008.
15. Kaufman, J., Antigen processing and presentation: evolution from a bird's eye view. Mol. Immunol. 2013. 55: 159-161.
16. Pyz, E., Naidenko, O., Miyake, S., Yamamura, T., Berberich, I., Cardell, S., Kronenberg, M. et al., The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR. J. Immunol. 2006. 176: 7447-7455.
17. Abbott, C. and S. Povey, Development of human chromosome-specific PCR primers for characterization of somatic cell hybrids. Genomics 1991. 9: 73-77.
18. Theune, S., Theune, S., Fung, J., Todd, S., Sakaguchi, A. Y. and Naylor, S. L., PCR primers for human chromosomes: reagents for the rapid analysis of somatic cell hybrids. Genomics 1991. 9: 511-516.
19. Amslinger, S., Kis, K., Hecht, S., Adam, P., Rohdich, F., Arigoni, D., Bacher, A. et al., Biosynthesis of terpenes. Preparation of (E)-1-Hydroxy- 2-methyl-but-2-enyl 4-diphosphate, an intermediate of the deoxyxylulose phosphate pathway. J. Org. Chem. 2002. 67: 4590-4594.
20. Deusch, K., Lüling, F., Reich, K., Classen, M., Wagner, H. and Pfeffer, K., A major fraction of human intraepithelial lymphocytes simultaneously expresses the gamma/delta T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment. Eur. J. Immunol. 1991. 21: 1053-1059.