Genome-wide association identifies regulatory loci associated with distinct local histogram emphysema patterns

American Journal of Respiratory and Critical Care Medicine

Volumn 190, Issue 4, 2014, Pages 399-409

  Castaldi, Peter J ^a   Cho, Michael H ^a,b   Estépar, Raúl San José ^b   McDonald, Merry Lynn N ^a   Laird, Nan ^c   Beaty, Terri H ^d   Washko, George ^b   Crapo, James D ^e   Silverman, Edwin K ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e DEPARTMENT OF MEDICINE   (United States)

Author keywords

COPD; Emphysema; Gene regulation; Genetics; Spiral computed tomography

Indexed keywords

DEOXYRIBONUCLEASE I;

ADULT; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CONE BEAM COMPUTED TOMOGRAPHY; CYP2A6 GENE; DISEASE PREDISPOSITION; ENHANCER REGION; EPIGENETICS; EPITHELIUM CELL; FEMALE; GENE; GENE CONTROL; GENE FUNCTION; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENOTYPE; HHIP GENE; HISTOGRAM; HUMAN; INVESTIGATIVE PROCEDURES; IREB2 GENE; LIMIT OF QUANTITATION; LONGITUDINAL STUDY; LUNG EMPHYSEMA; LUNG FIBROBLAST; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MMP12 GENE; MULTICENTER STUDY; PATTERN RECOGNITION; PHENOTYPE; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SPIROMETER; SPIROMETRY; TGFB2 GENE; AGED; CHROMOSOME MAP; CLINICAL TRIAL; EMPHYSEMA; GENETIC PREDISPOSITION; GENETICS; LUNG; METHODOLOGY; MIDDLE AGED; RADIOGRAPHY; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; STATISTICS; VERY ELDERLY;

COPD; EMPHYSEMA; GENE REGULATION; GENETICS; SPIRAL COMPUTED TOMOGRAPHY;

AGED; AGED, 80 AND OVER; CHROMOSOME MAPPING; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LONGITUDINAL STUDIES; LUNG; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PULMONARY EMPHYSEMA; SMOKING; TOMOGRAPHY, SPIRAL COMPUTED;

EID: 84907820687     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201403-0569OC     Document Type: Article

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