Motoneuron regeneration accuracy and recovery of gait after femoral nerve injuries in rats

Neuroscience

Volumn 280, Issue , 2014, Pages 73-87

  Kruspe, M ^a   Thieme, H ^a   Guntinas Lichius, O ^a   Irintchev, A ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Behavioral test; Peripheral nerve regeneration; Preferential motor reinnervation; Retrograde motoneuron labeling; Single frame motion analysis; Structure function correlations

Indexed keywords

ACCURACY; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DISEASE ASSOCIATION; DISEASE EXACERBATION; FEMALE; FEMORAL NERVE INJURY; FUNCTIONAL STATUS; GAIT; INJURY SEVERITY; MOTONEURON; NERVE PROJECTION; NERVE REGENERATION; NEUROLOGIC EXAMINATION; NONHUMAN; PERIPHERAL NERVE INJURY; PREDICTION; QUADRICEPS FEMORIS MUSCLE; RAT; REINNERVATION; SINGLE FRAME MOTION ANALYSIS; ANIMAL; CELL COUNT; DISEASE MODEL; FEMORAL NERVE; INJURIES; INNERVATION; MOTOR ACTIVITY; NERVE CRUSH; NERVE FIBER; NEUROANATOMICAL TRACT TRACING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REGRESSION ANALYSIS; SEVERITY OF ILLNESS INDEX; SUTURING METHOD; TIME; VIDEORECORDING; WISTAR RAT;

ANIMALS; AXONS; CELL COUNT; DISEASE MODELS, ANIMAL; FEMALE; FEMORAL NERVE; GAIT; MOTOR ACTIVITY; MOTOR NEURONS; NERVE CRUSH; NERVE REGENERATION; NEUROANATOMICAL TRACT-TRACING TECHNIQUES; QUADRICEPS MUSCLE; RATS, WISTAR; RECOVERY OF FUNCTION; REGRESSION ANALYSIS; SEVERITY OF ILLNESS INDEX; SUTURE TECHNIQUES; TIME FACTORS; VIDEO RECORDING;

EID: 84907778341     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.08.051     Document Type: Article

References (43)

1. Ahlborn P., Schachner M., Irintchev A. One hour electrical stimulation accelerates functional recovery after femoral nerve repair. Exp Neurol 2007, 208:137-144.
2. Angelov D., Guntinas-Lichius O., Wewetzer K., Neiss W., Streppel M. Axonal branching and recovery of coordinated muscle activity after transection of the facial nerve in adult rats. Adv Anat Embryol Cell Biol 2005, 180:1-130.
3. Apostolova I., Irintchev A., Schachner M. Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice. J Neurosci 2006, 26:7849-7859.
4. Badke A., Irintchev A.P., Wernig A. Maturation of transmission in reinnervated mouse soleus muscle. Muscle Nerve 1989, 12:580-586.
5. Beetz C., Koch N., Khundadze M., Zimmer G., Nietzsche S., Hertel N., Huebner A.K., Mumtaz R., Schweizer M., Dirren E., Karle K.N., Irintchev A., Alvarez V., Redies C., Westermann M., Kurth I., Deufel T., Kessels M.M., Qualmann B., Hubner C.A. A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. J Clin Invest 2013, 123:4273-4282.
6. Bland J.M., Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986, 1:307-310.
7. Bland J.M., Altman D.G. Measuring agreement in method comparison studies. Stat Methods Med Res 1999, 8:135-160.
8. Brown M.C., Holland R.L., Hopkins W.G. Motor nerve sprouting. Annu Rev Neurosci 1981, 4:17-42.
9. Brushart T. Preferential reinnervation of motor nerves by regenerating motor axons. J Neurosci 1988, 8:1026-1031.
10. Brushart T. Motor axons preferentially reinnervate motor pathways. J Neurosci 1993, 13:2730-2738.
11. Brushart T., Hoffman P., Royall R., Murinson B., Witzel C., Gordon T. Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron. J Neurosci 2002, 22:6631-6638.
12. de Ruiter G.C., Malessy M.J., Alaid A.O., Spinner R.J., Engelstad J.K., Sorenson E.J., Kaufman K.R., Dyck P.J., Windebank A.J. Misdirection of regenerating motor axons after nerve injury and repair in the rat sciatic nerve model. Exp Neurol 2008, 211:339-350.
13. Eberhardt K.A., Irintchev A., Al-Majed A.A., Simova O., Brushart T.M., Gordon T., Schachner M. BDNF/TrkB signaling regulates HNK-1 carbohydrate expression in regenerating motor nerves and promotes functional recovery after peripheral nerve repair. Exp Neurol 2006, 198:500-510.
14. Fey A., Schachner M., Irintchev A. A novel motion analysis approach reveals late recovery in C57BL/6 mice and deficits in NCAM-deficient mice after sciatic nerve crush. J Neurotrauma 2010, 27:815-828.
15. Franz C., Rutishauser U., Rafuse V. Intrinsic neuronal properties control selective targeting of regenerating motoneurons. Brain 2008, 131:1492-1505.
16. Franz C.K., Rutishauser U., Rafuse V.F. Polysialylated neural cell adhesion molecule is necessary for selective targeting of regenerating motor neurons. J Neurosci 2005, 25:2081-2091.
17. Guntinas-Lichius O., Angelov D.N., Morellini F., Lenzen M., Skouras E., Schachner M., Irintchev A. Opposite impacts of tenascin-C and tenascin-R deficiency in mice on the functional outcome of facial nerve repair. Eur J Neurosci 2005, 22:2171-2179.
18. Guseva D., Angelov D.N., Irintchev A., Schachner M. Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury. Brain 2009, 132:2180-2195.
19. Haftel V., Bichler E., Wang Q., Prather J., Pinter M., Cope T. Central suppression of regenerated proprioceptive afferents. J Neurosci 2005, 25:4733-4742.
20. Haley S.M., Fragala-Pinkham M.A. Interpreting change scores of tests and measures used in physical therapy. Phys Ther 2006, 86:735-743.
21. Huang J., Hu X., Lu L., Ye Z., Wang Y., Luo Z. Electrical stimulation accelerates motor functional recovery in autograft-repaired 10 mm femoral nerve gap in rats. J Neurotrauma 2009, 26:1805-1813.
22. Hundeshagen G., Szameit K., Thieme H., Finkensieper M., Angelov D.N., Guntinas-Lichius O., Irintchev A. Deficient functional recovery after facial nerve crush in rats is associated with restricted rearrangements of synaptic terminals in the facial nucleus. Neuroscience 2013, 248C:307-318.
23. Irintchev A. Potentials and limitations of peripheral nerve injury models in rodents with particular reference to the femoral nerve. Ann Anat 2011, 193:276-285.
24. Irintchev A., Draguhn A., Wernig A. Reinnervation and recovery of mouse soleus muscle after long-term denervation. Neuroscience 1990, 39:231-243.
25. Irintchev A., Simova O., Eberhardt K.A., Morellini F., Schachner M. Impacts of lesion severity and tyrosine kinase receptor B deficiency on functional outcome of femoral nerve injury assessed by a novel single-frame motion analysis in mice. Eur J Neurosci 2005, 22:802-808. Erratum. In: Eur J Neurosci. 2006 Feb; 23(4):1087.
26. Irintchev A., Wu M.M., Lee H.J., Zhu H., Feng Y.P., Liu Y.S., Bernreuther C., Loers G., You S.W., Schachner M. Glycomimetic improves recovery after femoral nerve injury in a non-human primate. J Neurotrauma 2011, 28:1295-1306.
27. Madison R., Archibald S., Brushart T. Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons. J Neurosci 1996, 16:5698-5703.
28. Madison R.D., Robinson G.A., Chadaram S.R. The specificity of motor neurone regeneration (preferential reinnervation). Acta Physiol (Oxf) 2007, 189:201-206.
29. Madison R.D., Sofroniew M.V., Robinson G.A. Schwann cell influence on motor neuron regeneration accuracy. Neuroscience 2009, 163:213-221.
30. Malin D., Sonnenberg-Riethmacher E., Guseva D., Wagener R., Aszodi A., Irintchev A., Riethmacher D. The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration. J Cell Sci 2009, 122:995-1004.
31. Mears S., Schachner M., Brushart T.M. Antibodies to myelin-associated glycoprotein accelerate preferential motor reinnervation. J Peripher Nerv Syst 2003, 8:91-99.
32. Mehanna A., Mishra B., Kurschat N., Schulze C., Bian S., Loers G., Irintchev A., Schachner M. Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice. Brain 2009, 132:1449-1462.
33. Navarro X., Vivó M., Valero-Cabré A. Neural plasticity after peripheral nerve injury and regeneration. Prog Neurobiol 2007, 82:163-201.
34. Nichols C.M., Myckatyn T.M., Rickman S.R., Fox I.K., Hadlock T., Mackinnon S.E. Choosing the correct functional assay: a comprehensive assessment of functional tests in the rat. Behav Brain Res 2005, 163:143-158.
35. Parry C. Trick movements. Proc R Soc Med 1970, 63:674-676.
36. Peitersen E. Bell's palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol 2002, (Suppl.):4-30.
37. Raslan A., Ernst P., Werle M., Thieme H., Szameit K., Finkensieper M., Guntinas-Lichius O., Irintchev A. Reduced cholinergic and glutamatergic synaptic input to regenerated motoneurons after facial nerve repair in rats: potential implications for recovery of motor function. Brain Struct Funct 2014, 219:891-909.
38. Robinson G.A., Madison R.D. Preferential motor reinnervation in the mouse: comparison of femoral nerve repair using a fibrin sealant or suture. Muscle Nerve 2003, 28:227-231.
39. Semler J., Wellmann K., Wirth F., Stein G., Angelova S., Ashrafi M., Schempf G., Ankerne J., Ozsoy O., Ozsoy U., Schonau E., Angelov D.N., Irintchev A. Objective measures of motor dysfunction after compression spinal cord injury in adult rats: correlations with locomotor rating scores. J Neurotrauma 2011, 28:1247-1258.
40. Simova O., Irintchev A., Mehanna A., Liu J.K., Dihne M., Bachle D., Sewald N., Loers G., Schachner M. Carbohydrate mimics promote functional recovery after peripheral nerve repair. Ann Neurol 2006, 60:430-437.
41. Udina E., Puigdemasa A., Navarro X. Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat. Muscle Nerve 2011, 43:500-509.
42. Weir J.P. Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. J Strength Cond Res 2005, 19:231-240.
43. Xu Q.G., Forden J., Walsh S.K., Gordon T., Midha R. Motoneuron survival after chronic and sequential peripheral nerve injuries in the rat. J Neurosurg 2010, 112:890-899.