Morphine and clonidine combination therapy improves therapeutic window in mice: Synergy in antinociceptive but not in sedative or cardiovascular effects

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Stone, Laura S ^a,b,c   German, Jonathan P ^e   Kitto, Kelly F ^e   Fairbanks, Carolyn A ^d,e   Wilcox, George L ^e  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLONIDINE; HOT WATER; MORPHINE; MORPHINE SULFATE; ALPHA 2 ADRENERGIC RECEPTOR; ANALGESIC AGENT; HYPNOTIC SEDATIVE AGENT; OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CARDIOVASCULAR DEPRESSION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CAROTID ARTERY DISEASE; CAROTID DISTENSION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG RESPONSE; DRUG SYNTHESIS; HEART RATE; ISOBOLOGRAPHIC ANALYSIS; MALE; MONOTHERAPY; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PAIN ASSESSMENT; PULSE OXIMETRY; ROTAROD TEST; SEDATION; TAIL FLICK TEST; WAKEFULNESS; WARM WATER TAIL FLICK TEST; ANIMAL; CHEMICALLY INDUCED; HUMAN; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; PAIN; PAIN MEASUREMENT; PATHOLOGY;

MUS;

ANALGESICS; ANIMALS; CARDIOVASCULAR DISEASES; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HUMANS; HYPNOTICS AND SEDATIVES; INJECTIONS, SPINAL; MICE; MORPHINE; PAIN; PAIN MEASUREMENT; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, OPIOID;

EID: 84907759023     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109903     Document Type: Article

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