Phthalate occurrence in rivers and tap water from central Spain

Science of the Total Environment

Volumn 500-501, Issue , 2014, Pages 139-146

  Dominguez Morueco N ^a   Gonzalez Alonso S ^a   Valcarcel Y ^a  

^a UNIVERSIDAD REY JUAN CARLOS   (Spain)

Author keywords

Endocrine disrupting compounds; Oestrogenic activity; Phthalates; Risk assessment; Surface water; Tap water

Indexed keywords

ENDOCRINE DISRUPTERS; ESTERS; HEALTH RISKS; POLLUTION DETECTION; POTABLE WATER; POTASSIUM COMPOUNDS; RISK ASSESSMENT; RIVERS; SURFACE WATERS; WATER TREATMENT;

DENSELY POPULATED REGIONS; DI-2-ETHYLHEXYL PHTHALATE; ENDOCRINE DISRUPTING COMPOUND; OESTROGENIC ACTIVITY; PHTHALATES; PRELIMINARY ASSESSMENT; PRELIMINARY RISK ASSESSMENT; TAP WATER;

RIVER POLLUTION;

DRINKING WATER; PHTHALIC ACID BENZYL BUTYL ESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID DIETHYL ESTER; PHTHALIC ACID DIMETHYL ESTER; RIVER WATER; TAP WATER; PHTHALIC ACID; WATER POLLUTANT;

CONCENTRATION (COMPOSITION); DRINKING WATER; ENDOCRINE DISRUPTOR; HEALTH RISK; PHTHALATE; RISK ASSESSMENT; RIVER POLLUTION; SURFACE WATER;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ESTROGEN ACTIVITY; GEOGRAPHIC DISTRIBUTION; GEOGRAPHIC ORIGIN; HEALTH HAZARD; POLLUTION MONITORING; POLLUTION TRANSPORT; RISK ASSESSMENT; RIVER ECOSYSTEM; SPAIN; WATER ANALYSIS; WATER CONTAMINATION; WATER POLLUTANT; WATER SAMPLING; ANALYSIS; CHEMISTRY; ENVIRONMENTAL MONITORING; RIVER; STATISTICS AND NUMERICAL DATA; WATER SUPPLY;

JARAMA RIVER; MADRID [SPAIN]; MANZANARES RIVER; SPAIN;

DRINKING WATER; ENVIRONMENTAL MONITORING; PHTHALIC ACIDS; RIVERS; SPAIN; WATER POLLUTANTS, CHEMICAL; WATER SUPPLY;

EID: 84907701753     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2014.08.098     Document Type: Article

References (39)

1. Al-Saleh I., Shinwari N., Alsabbaheen A. Phthalates residues in plastic bottled waters. J Toxicol Sci 2011, 36(4):469-478.
2. Amiridou D., Voutsa D. Alkylphenols and phthalates in bottled waters. J Hazard Mater 2011, 185(1):281-286.
3. Bartolomé L., Cortazar E., Raposo J.C., Usobiaga A., Zuloaga O., Etxebarria N., Fernández L.A. Simultaneous microwave-assisted extraction of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, phthalate esters and nonylphenols in sediments. J Chromatogr A 2005, 1068(2):229-236.
4. Bastos P.M., Haglund P. The use of comprehensive two-dimensional gas chromatography and structure-activity modeling for screening and preliminary risk assessment of organic contaminants in soil, sediment, and surface water. J Soils Sediments 2012, 12(7):1079-1088.
5. Berzas Nevado J.J., Rodríguez Martín-Doimeadios R.C., Guzmán Bernardo F.J., Jiménez Moreno M., Ortega Tardío S., Sánchez-Herrera Fornieles M.M., Martín-Nieto Ríos S., Doncel Pérez A. Integrated pollution evaluation of the Tagus River in Central Spain. Environ Monit Assess 2009, 156(1-4):461-477. 10.1007/s10661-008-0498-9.
6. Blanchard M., Teil M.J., Dargnat C., Alliot F., Chevreuil M. Assessment of adult human exposure to phthalate esters in the urban centre of Paris (France). Bull Environ Contam Toxicol 2013, 90(1):91-96.
7. Bono-Blay F., Guart A., De la Fuente B., Pedemonte M., Pastor M.C., Borrell A., Lacorte S. Survey of phthalates, alkylphenols, bisphenol A and herbicides in Spanish source waters intended for bottling. Environ Sci Pollut Res Int 2012, 19(8):3339-3349.
8. Calafat A.M., Needham L.L., Silva M.J., Lambert G. Exposure to di-(2-Ethylhexyl) phtalate among premature neonates in a neonatal intensive care unit. Pediatrics 2004, 113:429-434.
9. Céspedes R., Petrovic M., Raldúa D., Saura U., Pina B., Lacorte S., Viana P., Barceló D. Integrated procedure for determination of endocrine-disrupting activity in surface waters and sediments by use of the biological technique recombinant yeast assay and chemical analysis by LC-ESI-MS. Anal Bioanal Chem 2004, 378:697-708.
10. Chaler R., Cantón L., Vaquero M., Grimalt J.O. Identification and quantification of n-octyl esters of alkanoic and hexanedioic acids and phthalates as urban wastewater markers in biota and sediments from estuarine areas. J Chromatogr A 2004, 1046(1-2):203-210.
11. Dévier M.H., Le Menach K., Viglino L., Di Gioia L., Lachassagne P., Budzinski H. Ultra-trace analysis of hormones, pharmaceutical substances, alkylphenols and phthalates in two French natural mineral waters. Sci Total Environ 2013, 443:621-632.
12. Diamanti-Kandarakis E., Bourguignon J.P., Giudice L.C., Hauser R., Prins G.S., Soto A.M., Zoeller R.T., Gore A.C. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev 2009, 30(4):293-342.
13. European Parliament and the Council Directive N° 2005/84/EC of the European Parliament and of the Council of 14 December 2005 amending for the 22nd time Council Directive 76/769/EEC on the approximation of the laws, regulations and administrative provisions of the Member States relating to restrictions on the marketing and use of certain dangerous substances and preparations (phthalates in toys and childcare articles). OJEC 2005, 344:40-43. 27 December 2005.
14. European Commission Study on enhancing the endocrine disrupter priority list with a focus on low production volume chemicals Available:, [Last accessed March 2013]. http://ENV.D.4/ETU/2005/0028rec.europa.eu/environment/endocrine/documents/final_report_2007.pdf.
15. European Parliament and the Council Directive N° 2013/39/UE European Parliament and of the Council of 12 August 2013 amending Directives 2000/60/EC and 2008/105/EC are amended in relation to priority substances in the field of policy waters. OJEC 2013, 226:1-17. [24 August 2013].
16. He H., Hu G.J., Sun C., Chen S.L., Yang M.N., Li J., Zhao Y., et al. Trace analysis of persistent toxic substances in the main stream of Jiangsu section of the Yangtze River, China. Environ Sci Pollut Res Int 2011, 18(4):638-648. [I].
17. INE base National Statistics Institute on-line database Available:, [Last accessed March 2013]. http://www.ine.es/inebmenu/mnu_padron.htm.
18. Kim S.D., Cho J., Kim I.S., Vanderford B.J., Snyder S.A. Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters. Water Res 2007, 41(5):1013-1021. [Mar.].
19. Kimber I., Dearman R. An assessment of the ability of phthalates to influence immune and allergic responses. Toxicology 2010, 271:73-82.
20. Liu P., Tian T., Barreto J., Chou J. Assessment and analysis of phthalate esters, in Lake Pontchartrain, by SPME combining with GC-MS. Environ Technol 2013, 34(4):37-41.
21. López-Roldán R., de Alda M.L., Gros M., Petrovic M., Martín-Alonso J., Barceló D. Advanced monitoring of pharmaceuticals and estrogens in the Llobregat River basin (Spain) by liquid chromatography-triple quadrupole-tandem mass spectrometry in combination with ultra performance liquid chromatography-time of flight-mass spectrometry. Chemosphere 2010, 80(11):1337-1344.
22. Mankidy R., Wiseman S., Ma H., Giesy J.P. Biological impact of phthalates. Toxicol Lett 2013, 217(1):50-58. [The other authors have compared their results with those of other international studies].
23. Martí N., Aguado D., Segovia-Martínez L., Bouzas A., Seco A. Occurrence of priority pollutants in WWTP effluents and Mediterranean coastal waters of Spain. Mar Pollut Bull 2011, 62(3):615-625.
24. Olea N., Fernández M.F., Araque P., Olea-Serrano F. Perspectivas en disrupción endocrina. Gac Sanit 2002, 16(3):250-256.
25. Olujimi O.O., Fatoki O.S., Odendaal J.P., Daso A.P. Chemical monitoring and temporal variation in levels of endocrine disrupting chemicals (priority phenols and phthalate esters) from selected wastewater treatment plant and freshwater systems in Republic of South Africa. Microchem J 2012, 101:11-23.
26. Plotan M., Frizzell C., Robinson V., Elliott C.T., Connolly L. Endocrine disruptor activity in bottled mineral and flavoured water. Food Chem 2013, 136:1590-1596.
27. Regueiro J., Liompart M., Garcia-Jares C., Garcia-Monteagudo J.C., Cela R. Ultrasound-assisted emulsification-microextraction of emergent contaminants and pesticides in environmental waters. J Chromatogr A 2008, 1190:27-38.
28. Rivas A., Granada A., Jiménez M., Olea F., Olea N. Exposición humana a disruptores endocrinos 2004, 13(3):7-12.
29. Sánchez-Avila J., Bonet J., Velasco G., Lacorte S. Determination and occurrence of phthalates, alkylphenols, bisphenol A, PBDEs, PCBs and PAHs in an industrial sewage grid discharging to a Municipal Wastewater Treatment Plant. Sci Total Environ 2009, 407(13):4157-4167.
30. Sánchez-Avila J., Fernandez-Sanjuan M., Vicente J., Lacorte S. Development of a multi-residue method for the determination of organic micropollutants in water, sediment and mussels using gas chromatography-tandem mass spectrometry. J Chromatogr A 2011, 1217(17):2776-2781.
31. Sánchez-Avila J., Tauler R., Lacorte S. Organic micropollutants in coastal waters from NW Mediterranean Sea: sources distribution and potential risk. Environ Int 2012, 46:50-62.
32. Tang C.Y., Li A.Q., Guan Y.B., Li Y., Cheng X.M., Li P., Li S.Q., et al. Influence of polluted SY River on child growth and sex hormones. Biomed Environ Sci 2012, 25(3):291-296.
33. U.S.EPA (U.S.Environmental Protection Agency) Risk assessment guidance for Superfund Volume I Human Health Evaluation Manual (Part A) 1989, U.S. EPA, Washington, DC, [Available: http://www.epa.gov/oswer/riskassessment/ragsa/ Last accessed March 2013].
34. U.S.EPA (U.S.Environmental Protection Agency) 2012 edition of the drinking water standards and health advisories 2012, U.S. EPA, Washington, DC, [Available: http://water.epa.gov/action/advisories/drinking/upload/dwstandards2012.pdf Last accessed March 2013.].
35. Valcárcel Y., González Alonso S., Rodríguez-Gil J.L., Romo Maroto R., Gil A., Catalá M. Analysis of the presence of cardiovascular and analgesic/anti-inflammatory/antipyretic pharmaceuticals in river- and drinking-water of the Madrid Region in Spain. Chemosphere 2011, 82(7):1062-1071.
36. Watanabe M., Takano T., Nakamura K., Watanabe S., Seino K. Water quality and concentration of alkylphenols in rivers used as source of drinking water. Environ Health Prev Med 2007, 12:17-24.
37. Weiss B. The intersection of neurotoxicology and endocrine disruption. NeuroToxicology 2012, 33:1410-1419.
38. WHO Di(2-ethylhexyl)adipate in drinking-water. Background document for preparation of WHO Guidelines for Drinking-Water Quality 2003, World Health Organization, Geneva, [WHO/SDE/WSH/03.04/68].
39. Zhang R., Wang W., Shi X., Yu X., Li M., Xiao L., Cui Y. Health risk of semi-volatile organic pollutants in Wujin river inflow into Taihu Lake. Ecotoxicology 2011, 20(5):1083-1089.