Plasma biomarker discovery in preeclampsia using a novel differential isolation technology for circulating extracellular vesicles

American Journal of Obstetrics and Gynecology

Volumn 211, Issue 4, 2014, Pages 380.e1-380.e13

  Hian Tan, Kok ^a,b,c   Sim Tan, Soon ^e   Sze, Siu Kwan ^d   Ryan Lee, Wai Kheong ^a   Jack Ng, Mor ^a   Kiang Lim, Sai ^c  

^a KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

annexin V; biomarker discovery; cholera toxin B chain; extracellular vesicles; preeclampsia

Indexed keywords

EID: 84907686798     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2014.03.038     Document Type: Article

References (15)

1. E. Abalos, C. Cuesta, A.L. Grosso, D. Chou, and L. Say Global and regional estimates of preeclampsia and eclampsia: a systematic review Eur J Obstet Gynecol Reprod Biol 2013
2. K.H. Tan, K. Kwek, and G.S. Yeo Epidemiology of pre-eclampsia and eclampsia at the KK Women's and Children's Hospital, Singapore Singapore Med J 47 2006 48 53
3. B.M. Sibai Disparity in the rate of eclampsia and adverse pregnancy outcome from eclampsia: a tale of two countries Obstet Gynecol 118 2011 976 977
4. B. Sibai, G. Dekker, and M. Kupferminc Pre-eclampsia Lancet 365 2005 785 799
5. J. Espinoza Recent biomarkers for the identification of patients at risk for preeclampsia: the role of uteroplacental ischemia Expert Opin Med Diagn 6 2012 121 130
6. R.J. Simpson, J.W. Lim, R.L. Moritz, and S. Mathivanan Exosomes: proteomic insights and diagnostic potential Expert Rev Proteomics 6 2009 267 283
7. D.D. Taylor, S. Akyol, and C. Gercel-Taylor Pregnancy-associated exosomes and their modulation of T cell signaling J Immunol 176 2006 1534 1542
8. C. Thery, M. Ostrowski, and E. Segura Membrane vesicles as conveyors of immune responses Nat Rev Immunol 9 2009 581 593
9. D. Duijvesz, T. Luider, C.H. Bangma, and G. Jenster Exosomes as biomarker treasure chests for prostate cancer Eur Urol 59 2011 823 831
10. R.J. Simpson, and S. Mathivanan Extracellular microvesicles: the need for internationally recognised nomenclature and stringent purification criteria J Proteomics Bioinformatics 5 2012
11. A.J. Laude, and I.A. Prior Plasma membrane microdomains: organization, function and trafficking (Review) Mol Membrane Biol 21 2004 193 205
12. P.E. Rautou, and N. Mackman Del-etion of microvesicles from the circulation Circulation 125 2012 1601 1604
13. S.K. Sze, D.P. de Kleijn, and R.C. Lai Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells Mol Cell Proteomics 6 2007 1680 1689
14. R.F.A. Zwaal, and A.J. Schroit Pathophysiologic implications of membrane phospholipid asymmetry in blood cells Blood 89 1997 1121 1132
15. P.S. Niemelä, S. Ollila, M.T. Hyvönen, M. Karttunen, and I. Vattulainen Assessing the nature of lipid raft membranes PLoS Comput Biol 3 2007 e34