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Volumn 28, Issue 10, 2014, Pages 1670-1681

Conditional knockout of the androgen receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; ANDROGEN; ANDROGEN RECEPTOR; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; MESSENGER RNA; MYELOPID;

EID: 84907662010     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/me.2014-1154     Document Type: Article
Times cited : (50)

References (48)
  • 1
    • 0029919567 scopus 로고    scopus 로고
    • Testosterone is required for gonadotropin-releasing hormone stimulation of luteinizing hormone-β messenger ribonucleic acid expression in female rats
    • Yasin M, Dalkin AC, Haisenleder DJ, Marshall JC. Testosterone is required for gonadotropin-releasing hormone stimulation of luteinizing hormone-β messenger ribonucleic acid expression in female rats. Endocrinology. 1996;137:1265–1271
    • (1996) Endocrinology , vol.137 , pp. 1265-1271
    • Yasin, M.1    Dalkin, A.C.2    Haisenleder, D.J.3    Marshall, J.C.4
  • 2
    • 4344646412 scopus 로고    scopus 로고
    • Regulation of gonadotropins by inhibin and activin
    • Gregory SJ, Kaiser UB. Regulation of gonadotropins by inhibin and activin. Semin Reprod Med. 2004;22:253–267
    • (2004) Semin Reprod Med , vol.22 , pp. 253-267
    • Gregory, S.J.1    Kaiser, U.B.2
  • 3
    • 77952108994 scopus 로고    scopus 로고
    • Mechanisms of FSH synthesis: What we know, what we don’t, and why you should care
    • Bernard DJ, Fortin J, Wang Y, Lamba P. Mechanisms of FSH synthesis: what we know, what we don’t, and why you should care. Fertil Steril. 2010;93:2465–2485
    • (2010) Fertil Steril , vol.93 , pp. 2465-2485
    • Bernard, D.J.1    Fortin, J.2    Wang, Y.3    Lamba, P.4
  • 4
    • 71849088360 scopus 로고    scopus 로고
    • Hormones in synergy: Regulation of the pituitary gonadotropin genes
    • Thackray VG, Mellon PL, Coss D. Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol. 2010; 314:192–203
    • (2010) Mol Cell Endocrinol , vol.314 , pp. 192-203
    • Thackray, V.G.1    Mellon, P.L.2    Coss, D.3
  • 5
    • 84880831030 scopus 로고    scopus 로고
    • Androgen receptor drives transcription of rat PACAP in gonadotrope cells
    • Grafer CM, Halvorson LM. Androgen receptor drives transcription of rat PACAP in gonadotrope cells. Mol Endocrinol. 2013;27: 1343–1356
    • (2013) Mol Endocrinol , vol.27 , pp. 1343-1356
    • Grafer, C.M.1    Halvorson, L.M.2
  • 8
    • 0036645414 scopus 로고    scopus 로고
    • Molecular biology of the androgen receptor
    • Gelmann EP. Molecular biology of the androgen receptor. J Clin Oncol. 2002;20:3001–3015
    • (2002) J Clin Oncol , vol.20 , pp. 3001-3015
    • Gelmann, E.P.1
  • 9
    • 33646543761 scopus 로고    scopus 로고
    • Contributions of androgen and estrogen to fetal programming of ovarian dysfunction
    • Abbott DH, Padmanabhan V, Dumesic DA. Contributions of androgen and estrogen to fetal programming of ovarian dysfunction. Reprod Biol Endocrinol. 2006;4:17
    • (2006) Reprod Biol Endocrinol , vol.4
    • Abbott, D.H.1    Padmanabhan, V.2    Dumesic, D.A.3
  • 10
    • 3843142677 scopus 로고    scopus 로고
    • Subfertility and defective folliculogenesis in female mice lacking androgen receptor
    • Hu YC, Wang PH, Yeh S, et al. Subfertility and defective folliculogenesis in female mice lacking androgen receptor. Proc Natl Acad Sci USA. 2004;101:11209–11214
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 11209-11214
    • Hu, Y.C.1    Wang, P.H.2    Yeh, S.3
  • 11
    • 30444459607 scopus 로고    scopus 로고
    • Premature ovarian failure in androgen receptor-deficient mice
    • Shiina H, Matsumoto T, Sato T, et al. Premature ovarian failure in androgen receptor-deficient mice. Proc Natl Acad Sci USA. 2006; 103:224–229
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 224-229
    • Shiina, H.1    Matsumoto, T.2    Sato, T.3
  • 12
    • 34547093857 scopus 로고    scopus 로고
    • Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility
    • Walters KA, Allan CM, Jimenez M, et al. Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility. Endocrinology. 2007;148:3674–3684
    • (2007) Endocrinology , vol.148 , pp. 3674-3684
    • Walters, K.A.1    Allan, C.M.2    Jimenez, M.3
  • 13
    • 77954828598 scopus 로고    scopus 로고
    • Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function
    • Sen A, Hammes SR. Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function. Mol Endocrinol. 2010;24:1393–1403
    • (2010) Mol Endocrinol , vol.24 , pp. 1393-1403
    • Sen, A.1    Hammes, S.R.2
  • 14
    • 67649642147 scopus 로고    scopus 로고
    • Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function
    • Walters KA, McTavish KJ, Seneviratne MG, et al. Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function. Endocrinology. 2009;150:3274–3282
    • (2009) Endocrinology , vol.150 , pp. 3274-3282
    • Walters, K.A.1    McTavish, K.J.2    Seneviratne, M.G.3
  • 15
    • 14044254797 scopus 로고    scopus 로고
    • Testosterone stimulates follicle-stimulating hormone β transcription via activation of extracellular signal-regulated kinase: Evidence in rat pituitary cells
    • Haisenleder DJ, Burger LL, Aylor KW, et al. Testosterone stimulates follicle-stimulating hormone β transcription via activation of extracellular signal-regulated kinase: evidence in rat pituitary cells. Biol Reprod. 2005;72:523–529
    • (2005) Biol Reprod , vol.72 , pp. 523-529
    • Haisenleder, D.J.1    Burger, L.L.2    Aylor, K.W.3
  • 16
    • 0025611801 scopus 로고
    • Androgens positively regulate follicle-stimulating hormone β-subunit mRNA levels in rat pituitary cells
    • Gharib SD, Leung PC, Carroll RS, Chin WW. Androgens positively regulate follicle-stimulating hormone β-subunit mRNA levels in rat pituitary cells. Mol Endocrinol. 1990;4:1620–1626
    • (1990) Mol Endocrinol , vol.4 , pp. 1620-1626
    • Gharib, S.D.1    Leung, P.C.2    Carroll, R.S.3    Chin, W.W.4
  • 17
    • 0026531312 scopus 로고
    • Gonadal steroids effect similar regulation of gonadotrophin subunit mRNA expression in both male and female rats
    • Dalkin AC, Paul SJ, Haisenleder DJ, Ortolano GA, Yasin M, Marshall JC. Gonadal steroids effect similar regulation of gonadotrophin subunit mRNA expression in both male and female rats. J Endocrinol. 1992;132:39–45
    • (1992) J Endocrinol , vol.132 , pp. 39-45
    • Dalkin, A.C.1    Paul, S.J.2    Haisenleder, D.J.3    Ortolano, G.A.4    Yasin, M.5    Marshall, J.C.6
  • 18
    • 0026509650 scopus 로고
    • Effects of testosterone on gonadotropin subunit messenger ribonucleic acids in the presence or absence of gonadotropin-releasing hormone
    • Winters SJ, Ishizaka K, Kitahara S, Troen P, Attardi B. Effects of testosterone on gonadotropin subunit messenger ribonucleic acids in the presence or absence of gonadotropin-releasing hormone. Endocrinology. 1992;130:726–734
    • (1992) Endocrinology , vol.130 , pp. 726-734
    • Winters, S.J.1    Ishizaka, K.2    Kitahara, S.3    Troen, P.4    Attardi, B.5
  • 19
    • 33747846303 scopus 로고    scopus 로고
    • Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone β-subunit gene expression at the level of the gonadotrope
    • Thackray VG, McGillivray SM, Mellon PL. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone β-subunit gene expression at the level of the gonadotrope. Mol Endocrinol. 2006;20:2062–2079
    • (2006) Mol Endocrinol , vol.20 , pp. 2062-2079
    • Thackray, V.G.1    McGillivray, S.M.2    Mellon, P.L.3
  • 20
    • 0034749483 scopus 로고    scopus 로고
    • Androgen suppression of GnRH-stimulated ratLHβ gene transcription occurs through Sp1 sites in the distal GnRH-responsive promoter region
    • Curtin D, Jenkins S, Farmer N, et al. Androgen suppression of GnRH-stimulated ratLHβ gene transcription occurs through Sp1 sites in the distal GnRH-responsive promoter region. Mol Endocrinol. 2001;15:1906–1917
    • (2001) Mol Endocrinol , vol.15 , pp. 1906-1917
    • Curtin, D.1    Jenkins, S.2    Farmer, N.3
  • 21
    • 0034824440 scopus 로고    scopus 로고
    • AR suppresses transcription of the LHβ subunit by interacting with steroidogenic factor-1
    • Jorgensen JS, Nilson JH. AR suppresses transcription of the LHβ subunit by interacting with steroidogenic factor-1. Mol Endocrinol. 2001;15:1505–1516
    • (2001) Mol Endocrinol , vol.15 , pp. 1505-1516
    • Jorgensen, J.S.1    Nilson, J.H.2
  • 22
    • 0037108766 scopus 로고    scopus 로고
    • Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues
    • Yeh S, Tsai MY, Xu Q, et al. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci USA. 2002;99:13498–13503
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13498-13503
    • Yeh, S.1    Tsai, M.Y.2    Xu, Q.3
  • 23
    • 77956336197 scopus 로고    scopus 로고
    • Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor
    • Brothers KJ, Wu S, DiVall SA, et al. Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab. 2010;12:295–305
    • (2010) Cell Metab , vol.12 , pp. 295-305
    • Brothers, K.J.1    Wu, S.2    Divall, S.A.3
  • 24
  • 25
    • 84897882480 scopus 로고    scopus 로고
    • Obesity induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell
    • Wu S, Divall S, Nwaopara A, et al. Obesity induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell. Diabetes. 2014;63:1270–1282
    • (2014) Diabetes , vol.63 , pp. 1270-1282
    • Wu, S.1    Divall, S.2    Nwaopara, A.3
  • 26
    • 84555186997 scopus 로고    scopus 로고
    • Reproductive tissues maintain insulin sensitivity in diet-induced obesity
    • Wu S, Divall S, Wondisford F, Wolfe A. Reproductive tissues maintain insulin sensitivity in diet-induced obesity. Diabetes. 2012;61: 114–123
    • (2012) Diabetes , vol.61 , pp. 114-123
    • Wu, S.1    Divall, S.2    Wondisford, F.3    Wolfe, A.4
  • 27
    • 0033819596 scopus 로고    scopus 로고
    • Localization of androgen and estrogen receptors in rat and primate tissues
    • Pelletier G. Localization of androgen and estrogen receptors in rat and primate tissues. Histol Histopathol. 2000;15:1261–1270
    • (2000) Histol Histopathol , vol.15 , pp. 1261-1270
    • Pelletier, G.1
  • 29
    • 0027398053 scopus 로고
    • Correlations among three measures of puberty in mice and relationships with estradiol concentration and ovulation
    • Safranski TJ, Lamberson WR, Keisler DH. Correlations among three measures of puberty in mice and relationships with estradiol concentration and ovulation. Biol Reprod. 1993;48:669–673
    • (1993) Biol Reprod , vol.48 , pp. 669-673
    • Safranski, T.J.1    Lamberson, W.R.2    Keisler, D.H.3
  • 30
    • 0025898603 scopus 로고
    • Evidence for an autocrine role of activin B within rat anterior pituitary cultures
    • Corrigan AZ, Bilezikjian LM, Carroll RS, et al. Evidence for an autocrine role of activin B within rat anterior pituitary cultures. Endocrinology. 1991;128:1682–1684
    • (1991) Endocrinology , vol.128 , pp. 1682-1684
    • Corrigan, A.Z.1    Bilezikjian, L.M.2    Carroll, R.S.3
  • 31
    • 0026544755 scopus 로고
    • Passive immunoneutralization with a monoclonal antibody reveals a role for endogenous activin- B in mediating FSH hypersecretion during estrus and following ovariectomy of hypophysectomized, pituitary-grafted rats
    • DePaolo LV, Bald LN, Fendly BM. Passive immunoneutralization with a monoclonal antibody reveals a role for endogenous activin- B in mediating FSH hypersecretion during estrus and following ovariectomy of hypophysectomized, pituitary-grafted rats. Endocrinology. 1992;130:1741–1743
    • (1992) Endocrinology , vol.130 , pp. 1741-1743
    • Depaolo, L.V.1    Bald, L.N.2    Fendly, B.M.3
  • 32
    • 34249660014 scopus 로고    scopus 로고
    • Anterior pituitary gene expression with reproductive aging in the female rat
    • Zheng W, Jimenez-Linan M, Rubin BS, Halvorson LM. Anterior pituitary gene expression with reproductive aging in the female rat. Biol Reprod. 2007;76:1091–1102
    • (2007) Biol Reprod , vol.76 , pp. 1091-1102
    • Zheng, W.1    Jimenez-Linan, M.2    Rubin, B.S.3    Halvorson, L.M.4
  • 33
    • 84893159043 scopus 로고    scopus 로고
    • Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression
    • Garrel G, Simon V, Denoyelle C, et al. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression. Endocrinology. 2014;155:592–604
    • (2014) Endocrinology , vol.155 , pp. 592-604
    • Garrel, G.1    Simon, V.2    Denoyelle, C.3
  • 34
    • 33244484351 scopus 로고    scopus 로고
    • Changes in alpha-estradiol receptor and progesterone receptor expression in the locus coeruleus and preoptic area throughout the rat estrous cycle
    • Helena CV, de Oliveira Poletini M, Sanvitto GL, et al. Changes in alpha-estradiol receptor and progesterone receptor expression in the locus coeruleus and preoptic area throughout the rat estrous cycle. J Endocrinol. 2006;188:155–165
    • (2006) J Endocrinol , vol.188 , pp. 155-165
    • Helena, C.V.1    De Oliveira Poletini, M.2    Sanvitto, G.L.3
  • 35
    • 33745219480 scopus 로고    scopus 로고
    • Testosterone antagonist (flutamide) blocks ovulation and preovulatory surges of progesterone, luteinizing hormone and oestradiol in laying hens
    • Rangel PL, Sharp PJ, Gutierrez CG. Testosterone antagonist (flutamide) blocks ovulation and preovulatory surges of progesterone, luteinizing hormone and oestradiol in laying hens. Reproduction. 2006;131:1109–1114
    • (2006) Reproduction , vol.131 , pp. 1109-1114
    • Rangel, P.L.1    Sharp, P.J.2    Gutierrez, C.G.3
  • 36
    • 0028544043 scopus 로고
    • Administration of testosterone during the follicular phase increased the number of corpora lutea in gilts
    • Cárdenas H, Pope WF. Administration of testosterone during the follicular phase increased the number of corpora lutea in gilts. J Anim Sci. 1994;72:2930–2935
    • (1994) J Anim Sci , vol.72 , pp. 2930-2935
    • Cárdenas, H.1    Pope, W.F.2
  • 37
    • 0031877054 scopus 로고    scopus 로고
    • Effect of androgens on the development of mouse follicles growing in vitro
    • Murray AA, Gosden RG, Allison V, Spears N. Effect of androgens on the development of mouse follicles growing in vitro. J Reprod Fertil. 1998;113:27–33
    • (1998) J Reprod Fertil , vol.113 , pp. 27-33
    • Murray, A.A.1    Gosden, R.G.2    Allison, V.3    Spears, N.4
  • 38
    • 0020028583 scopus 로고
    • Serum testosterone concentrations during the 4-day estrous cycle in normal and adrenalectomized rats
    • Rush ME, Blake CA. Serum testosterone concentrations during the 4-day estrous cycle in normal and adrenalectomized rats. Proc Soc Exp Biol Med. 1982;169:216–221
    • (1982) Proc Soc Exp Biol Med , vol.169 , pp. 216-221
    • Rush, M.E.1    Blake, C.A.2
  • 39
    • 0022639025 scopus 로고
    • Androgen receptors in brain and pituitary of female rats: Cyclic changes and comparisons with the male
    • Handa RJ, Reid DL, Resko JA. Androgen receptors in brain and pituitary of female rats: cyclic changes and comparisons with the male. Biol Reprod. 1986;34:293–303
    • (1986) Biol Reprod , vol.34 , pp. 293-303
    • Handa, R.J.1    Reid, D.L.2    Resko, J.A.3
  • 40
    • 1842583504 scopus 로고    scopus 로고
    • Androgen regulates follicle-stimulating hormone β gene expression in an activin-dependent manner in immortalized gonadotropes
    • Spady TJ, Shayya R, Thackray VG, Ehrensberger L, Bailey JS, Mellon PL. Androgen regulates follicle-stimulating hormone β gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol. 2004;18:925–940
    • (2004) Mol Endocrinol , vol.18 , pp. 925-940
    • Spady, T.J.1    Shayya, R.2    Thackray, V.G.3    Ehrensberger, L.4    Bailey, J.S.5    Mellon, P.L.6
  • 41
    • 34547130298 scopus 로고    scopus 로고
    • The regulation of FSHβ transcription by gonadal steroids: Testosterone and estradiol modulation of the activin intracellular signaling pathway
    • Burger LL, Haisenleder DJ, Wotton GM, Aylor KW, Dalkin AC, Marshall JC. The regulation of FSHβ transcription by gonadal steroids: testosterone and estradiol modulation of the activin intracellular signaling pathway. Am J Physiol Endocrinol Metab. 2007; 293:E277–E285
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , pp. E277-E285
    • Burger, L.L.1    Haisenleder, D.J.2    Wotton, G.M.3    Aylor, K.W.4    Dalkin, A.C.5    Marshall, J.C.6
  • 42
    • 40849142335 scopus 로고    scopus 로고
    • Synergistic induction of follicle-stimulating hormone β-subunit gene expression by gonadal steroid hormone receptors and Smad proteins
    • Thackray VG, Mellon PL. Synergistic induction of follicle-stimulating hormone β-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology. 2008;149: 1091–1102
    • (2008) Endocrinology , vol.149 , pp. 1091-1102
    • Thackray, V.G.1    Mellon, P.L.2
  • 43
    • 0033058980 scopus 로고    scopus 로고
    • Is gonadotrope expression of the gonadotropin releasing hormone receptor gene mediated by autocrine/paracrine stimulation of an activin response element?
    • Duval DL, Ellsworth BS, Clay CM. Is gonadotrope expression of the gonadotropin releasing hormone receptor gene mediated by autocrine/paracrine stimulation of an activin response element? Endocrinology. 1999;140:1949–1952
    • (1999) Endocrinology , vol.140 , pp. 1949-1952
    • Duval, D.L.1    Ellsworth, B.S.2    Clay, C.M.3
  • 44
    • 0028577132 scopus 로고
    • The proximal promoter of the bovine luteinizing hormone β-subunit gene confers gonadotrope- specific expression and regulation by gonadotropin-releasing hormone, testosterone, and 17 β-estradiol in transgenic mice
    • Keri RA, Wolfe MW, Saunders TL, et al. The proximal promoter of the bovine luteinizing hormone β-subunit gene confers gonadotrope- specific expression and regulation by gonadotropin-releasing hormone, testosterone, and 17 β-estradiol in transgenic mice. Mol Endocrinol. 1994;8:1807–1816
    • (1994) Mol Endocrinol , vol.8 , pp. 1807-1816
    • Keri, R.A.1    Wolfe, M.W.2    Saunders, T.L.3
  • 45
    • 0034812429 scopus 로고    scopus 로고
    • Inhibin, activin, and follistatin in human fetal pituitary and gonadal physiology
    • Blumenfeld Z, Ritter M. Inhibin, activin, and follistatin in human fetal pituitary and gonadal physiology. Ann NY Acad Sci. 2001; 943:34–48
    • (2001) Ann NY Acad Sci , vol.943 , pp. 34-48
    • Blumenfeld, Z.1    Ritter, M.2
  • 46
    • 25444494962 scopus 로고    scopus 로고
    • Activin regulates luteinizing hormone β-subunit gene expression through Smadbinding and homeobox elements
    • Coss D, Thackray VG, Deng CX, Mellon PL. Activin regulates luteinizing hormone β-subunit gene expression through Smadbinding and homeobox elements. Mol Endocrinol. 2005;19:2610-2623
    • (2005) Mol Endocrinol , vol.19 , pp. 2610-2623
    • Coss, D.1    Thackray, V.G.2    Deng, C.X.3    Mellon, P.L.4
  • 47
    • 0022408207 scopus 로고
    • Gonadotrophin releasing hormone receptor regulation in relationship to gonadotrophin secretion
    • Clayton RN, Detta A, Naik SI, Young LS, Charlton HM. Gonadotrophin releasing hormone receptor regulation in relationship to gonadotrophin secretion. J Steroid Biochem. 1985;23:691–702
    • (1985) J Steroid Biochem , vol.23 , pp. 691-702
    • Clayton, R.N.1    Detta, A.2    Naik, S.I.3    Young, L.S.4    Charlton, H.M.5
  • 48
    • 0018966022 scopus 로고
    • Characterization of gonadotropinreleasing hormone receptors in cultured rat pituitary cells
    • Naor Z, Clayton RN, Catt KJ. Characterization of gonadotropinreleasing hormone receptors in cultured rat pituitary cells. Endocrinology. 1980;107:1144-1152.
    • (1980) Endocrinology , vol.107 , pp. 1144-1152
    • Naor, Z.1    Clayton, R.N.2    Catt, K.J.3


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