Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: A case-control study

Breast Cancer Research

Volumn 14, Issue 2, 2012, Pages

  Yao, Song ^a   Zirpoli, Gary ^a   Bovbjerg, Dana H ^b   Jandorf, Lina ^c   Hong, Chi Chen ^a   Zhao, Hua ^a   Sucheston, Lara E ^a   Tang, Li ^a   Roberts, Michelle ^a   Ciupak, Gregory ^a   Davis, Warren ^a   Hwang, Helena ^a   Johnson, Candace S ^a   Trump, Donald L ^a   McCann, Susan E ^a   Ademuyiwa, Foluso ^a   Pawlish, Karen S ^d   Bandera, Elisa V ^e   Ambrosone, Christine B ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d NEW JERSEY DEPARTMENT OF HEALTH AND SENIOR SERVICES   (United States)

^e ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; ESTROGEN RECEPTOR; VITAMIN D RECEPTOR; 25-HYDROXYVITAMIN D; CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL RECEPTOR; DRUG DERIVATIVE; STEROID MONOOXYGENASE; VITAMIN D; VITAMIN D 24 HYDROXYLASE; VITAMIN D 24-HYDROXYLASE;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; EUROPEAN AMERICAN; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; RACE DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; BLOOD; BREAST TUMOR; CAUCASIAN; GENETICS; METABOLISM; MIDDLE AGED; RISK FACTOR;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; AFRICAN AMERICANS; BREAST NEOPLASMS; CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CALCITRIOL; RECEPTORS, ESTROGEN; RISK FACTORS; STEROID HYDROXYLASES; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84859340754     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3162     Document Type: Article

References (45)

1. Amend K, Hicks D, Ambrosone CB. Breast cancer in African-American women: differences in tumor biology from European-American women. Cancer Res 2006, 66:8327-8330. 10.1158/0008-5472.CAN-06-1927, 16951137.
2. Ooi LL, Zhou H, Kalak R, Zheng Y, Conigrave AD, Seibel MJ, Dunstan CR. Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Res 2010, 70:1835-1844. 10.1158/0008-5472.CAN-09-3194, 20160035.
3. Fumagalli M, Sironi M, Pozzoli U, Ferrer-Admettla A, Pattini L, Nielsen R. Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution. PLoS Genet 2011, 7:e100235.
4. Yuen AW, Jablonski NG. Vitamin D: in the evolution of human skin colour. Med Hypotheses 2010, 74:39-44. 10.1016/j.mehy.2009.08.007, 19717244.
5. Jablonski NG. The evolution of human skin and skin color. Ann Rev Anthropol 2004, 33:585-623.
6. Chaplin G, Jablonski NG. Vitamin D and the evolution of human depigmentation. Am J Phys Anthropol 2009, 139:451-461. 10.1002/ajpa.21079, 19425101.
7. Clemens TL, Adams JS, Henderson SL, Holick MF. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet 1982, 1:74-76.
8. Nesby-O'Dell S, Scanlon KS, Cogswell ME, Gillespie C, Hollis BW, Looker AC, Allen C, Doughertly C, Gunter EW, Bowman BA. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 2002, 76:187-192.
9. Ginde AA, Liu MC, Camargo CA. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med 2009, 169:626-632. 10.1001/archinternmed.2008.604, 19307527.
10. Wejse C, Olesen R, Rabna P, Kaestel P, Gustafson P, Aaby P, Andersen PL, Glerup H, Sodemann M. Serum 25-hydroxyvitamin D in a West African population of tuberculosis patients and unmatched healthy controls. Am J Clin Nutr 2007, 86:1376-1383.
11. Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 2007, 7:684-700. 10.1038/nrc2196, 17721433.
12. Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, Lam AC, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Newport MJ, Clayton DG, Todd JA. Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet 2004, 13:1633-1639. 10.1093/hmg/ddh169, 15175274.
13. Zinser G, Packman K, Welsh J. Vitamin D(3) receptor ablation alters mammary gland morphogenesis. Development 2002, 129:3067-3076.
14. Welsh J. Vitamin D and breast cancer: insights from animal models. Am J Clin Nutr 2004, 80:1721S-1724S.
15. Welsh J. Vitamin D and prevention of breast cancer. Acta Pharmacol Sin 2007, 28:1373-1382. 10.1111/j.1745-7254.2007.00700.x, 17723171.
16. International Agency for Research on Cancer Vitamin D and cancer. IACR Working Group Reports 2008, 5. Lyon, France: International Agency for Research on Cancer, International Agency for Research on Cancer.
17. Chlebowski RT, Johnson KC, Kooperberg C, Pettinger M, Wactawski-Wende J, Rohan T, Rossouw J, Lane D, O'Sullivan MJ, Yasmeen S, Hiatt RA, Shikany JM, Vitolins M, Khandekar J, Hubbell FA. Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst 2008, 100:1581-1591. 10.1093/jnci/djn360, 2673920, 19001601.
18. Zinser GM, Suckow M, Welsh J. Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues. J Steroid Biochem Mol Biol 2005, 97:153-164. 10.1016/j.jsbmb.2005.06.024, 16111884.
19. Neuhouser ML, Sorensen B, Hollis BW, Ambs A, Ulrich CM, McTiernan A, Bernstein L, Wayne S, Gilliland F, Baumgartner K, Baumgartner R, Ballard-Barbash R. Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors. Am J Clin Nutr 2008, 88:133-139. 2997620, 18614733.
20. Abbas S, Chang-Claude J, Linseisen J. Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study. Int J Cancer 2009, 124:250-255. 10.1002/ijc.23904, 18839430.
21. Abbas S, Linseisen J, Chang-Claude J. Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study. Nutr Cancer 2007, 59:54-61. 10.1080/01635580701390223, 17927502.
22. Yao S, Sucheston LE, Millen AE, Johnson CS, Trump DL, Nesline MK, Davis W, Hong CC, McCann SE, Hwang H, Kulkarni S, Edge SB, O'Connor TL, Ambrosone CB. Pretreatment serum concentrations of 25-hydroxyvitamin D and breast cancer prognostic characteristics: a case-control and a case-series study. PLoS One 2011, 6:e17251. 10.1371/journal.pone.0017251, 3046139, 21386992.
23. Ambrosone CB, Ciupak GL, Bandera EV, Jandorf L, Bovbjerg DH, Zirpoli G, Pawlish K, Godbold J, Furberg H, Fatone A, Valdimarsdottir H, Yao S, Li Y, Hwang H, Davis W, Roberts M, Sucheston L, Demissie K, Amend KL, Tartter P, Reilly J, Pace BW, Rohan T, Sparano J, Raptis G, Castaldi M, Estabrook A, Feldman S, Weltz C, Kemeny M. Conducting molecular epidemiological research in the age of HIPAA: a multi-institutional case-control study of breast cancer in African-American and European-American women. J Oncol 2009, 2009:871250. 2766507, 19865486.
24. The International HapMap Consortium The International HapMap Project. Nature 2003, 426:789-796. 10.1038/nature02168, 14685227, The International HapMap Consortium.
25. SeattleSNPs Genome Variation Server. , http://gvs.gs.washington.edu/GVS/
26. Xu Z, Kaplan NL, Taylor JA. TAGster: efficient selection of LD tag SNPs in single or multiple populations. Bioinformatics 2007, 23:3254-3255. 10.1093/bioinformatics/btm426, 2782964, 17827206.
27. Tsai HJ, Choudhry S, Naqvi M, Rodriguez-Cintron W, Burchard EG, Ziv E. Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populations. Hum Genet 2005, 118:424-433. 10.1007/s00439-005-0067-z, 16208514.
28. Pritchard JK, Stephens M, Donnelly P. Inference of population structure using multilocus genotype data. Genetics 2000, 155:945-959. 1461096, 10835412.
29. Luna A, Nicodemus KK. snp.plotter: an R-based SNP/haplotype association and linkage disequilibrium plotting package. Bioinformatics 2007, 23:774-776. 10.1093/bioinformatics/btl657, 17234637.
30. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D. The structure of haplotype blocks in the human genome. Science 2002, 296:2225-2229. 10.1126/science.1069424, 12029063.
31. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81:559-575. 10.1086/519795, 1950838, 17701901.
32. Zhang W, Duan S, Kistner EO, Bleibel WK, Huang RS, Clark TA, Chen TX, Schweitzer AC, Blume JE, Cox NJ, Dolan ME. Evaluation of genetic variation contributing to differences in gene expression between populations. Am J Hum Genet 2008, 82:631-640. 10.1016/j.ajhg.2007.12.015, 2427223, 18313023.
33. Signorello LB, Williams SM, Zheng W, Smith JR, Long J, Cai Q, Hargreaves MK, Hollis BW, Blot WJ. Blood vitamin d levels in relation to genetic estimation of African ancestry. Cancer Epidemiol Biomarkers Prev 2010, 19:2325-2331. 10.1158/1055-9965.EPI-10-0482, 2938736, 20647395.
34. Curran JE, Vaughan T, Lea RA, Weinstein SR, Morrison NA, Griffiths LR. Association of A vitamin D receptor polymorphism with sporadic breast cancer development. Int J Cancer 1999, 83:723-726. 10.1002/(SICI)1097-0215(19991210)83:6<723::AID-IJC4>3.0.CO;2-3, 10597185.
35. Sillanpaa P, Hirvonen A, Kataja V, Eskelinen M, Kosma VM, Uusitupa M, Vainio H, Mitrunen K. Vitamin D receptor gene polymorphism as an important modifier of positive family history related breast cancer risk. Pharmacogenetics 2004, 14:239-245. 10.1097/00008571-200404000-00003, 15083068.
36. Hou MF, Tien YC, Lin GT, Chen CJ, Liu CS, Lin SY, Huang TJ. Association of vitamin D receptor gene polymorphism with sporadic breast cancer in Taiwanese patients. Breast Cancer Res Treat 2002, 74:1-7. 10.1023/A:1016048900049, 12150447.
37. Arai H, Miyamoto KI, Yoshida M, Yamamoto H, Taketani Y, Morita K, Kubota M, Yoshida S, Ikeda M, Watabe F, Kanemasa Y, Takeda E. The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene. J Bone Miner Res 2001, 16:1256-1264. 10.1359/jbmr.2001.16.7.1256, 11450701.
38. Fang Y, van Meurs JB, Bergink AP, Hofman A, van Duijn CM, van Leeuwen JP, Pols HA, Uitterlinden AG. Cdx-2 polymorphism in the promoter region of the human vitamin D receptor gene determines susceptibility to fracture in the elderly. J Bone Miner Res 2003, 18:1632-1641. 10.1359/jbmr.2003.18.9.1632, 12968672.
39. Abbas S, Nieters A, Linseisen J, Slanger T, Kropp S, Mutschelknauss EJ, Flesch-Janys D, Chang-Claude J. Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk. Breast Cancer Res 2008, 10:R31. 10.1186/bcr1994, 2397533, 18419802.
40. John EM, Schwartz GG, Koo J, Wang W, Ingles SA. Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic population. Am J Epidemiol 2007, 166:1409-1419. 10.1093/aje/kwm259, 17934201.
41. VandeVord PJ, Wooley PH, Darga LL, Severson RK, Wu B, Nelson DA. Genetic determinants of bone mass do not relate with breast cancer risk in US white and African-American women. Breast Cancer Res Treat 2006, 100:103-107. 10.1007/s10549-006-9228-6, 16791482.
42. Trabert B, Malone KE, Daling JR, Doody DR, Bernstein L, Ursin G, Marchbanks PA, Strom BL, Humphrey MC, Ostrander EA. Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American women. Breast Cancer Res 2007, 9:R84. 10.1186/bcr1833, 2246187, 18067661.
43. Poynter JN, Jacobs ET, Figueiredo JC, Lee WH, Conti DV, Campbell PT, Levine AJ, Limburg P, Le Marchand L, Cotterchio M, Newcomb PA, Potter JD, Jenkins MA, Hopper JL, Duggan DJ, Baron JA, Haile RW. Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 2010, 19:525-536. 10.1158/1055-9965.EPI-09-0662, 2819604, 20086113.
44. Kahles H, Morahan G, Todd JA, Badenhoop K. Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes. Genes Immun 2009, 10(Suppl 1):S60-63. 2805827, 19956103.
45. Townsend K, Banwell CM, Guy M, Colston KW, Mansi JL, Stewart PM, Campbell MJ, Hewison M. Autocrine metabolism of vitamin D in normal and malignant breast tissue. Clin Cancer Res 2005, 11:3579-3586. 10.1158/1078-0432.CCR-04-2359, 15867263.