Effects of preoperative local estrogen in postmenopausal women with prolapse: A randomized trial

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 10, 2014, Pages 3728-3736

  Rahn, David D ^a   Good, Meadow M ^a   Roshanravan, Shayzreen M ^a   Shi, Haolin ^a   Schaffer, Joseph I ^a   Singh, Ravinder J ^b   Word, R Ann ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1 ALPHA1; COLLAGEN TYPE 1 ALPHA2; COLLAGEN TYPE 3; CONJUGATED ESTROGEN; ESTRADIOL; ESTRONE; GELATINASE B; MACROPHAGE ELASTASE; MESSENGER RNA; PLACEBO; UNCLASSIFIED DRUG; AGENTS USED INTRAVAGINALLY; COLLAGENASE; ESTROGEN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONNECTIVE TISSUE; CONTROLLED STUDY; DEGRADATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ESTRADIOL BLOOD LEVEL; ESTRONE BLOOD LEVEL; EVENING DOSAGE; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYSTERECTOMY; LIQUID CHROMATOGRAPHY; PATIENT COMPLIANCE; PELVIC ORGAN PROLAPSE; POSTMENOPAUSE; PREOPERATIVE TREATMENT; RANDOMIZED CONTROLLED TRIAL; REAL TIME POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TREATMENT DURATION; VAGINA; VAGINA MUCOSA; VAGINA WALL; BIOPSY; BLOOD; FOLLOW UP; INTRAVAGINAL DRUG ADMINISTRATION; MEDICATION COMPLIANCE; METABOLISM; MIDDLE AGED; MUCOSA; PATHOLOGY; PEROPERATIVE CARE; PROCEDURES; UTERINE PROLAPSE;

ADMINISTRATION, INTRAVAGINAL; BIOPSY; COLLAGEN; COLLAGENASES; DOUBLE-BLIND METHOD; ESTRADIOL; ESTROGENS; ESTROGENS, CONJUGATED (USP); ESTRONE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTRAOPERATIVE CARE; MEDICATION ADHERENCE; MIDDLE AGED; MUCOUS MEMBRANE; POSTMENOPAUSE; UTERINE PROLAPSE; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 84907610897     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-1216     Document Type: Article

References (24)

1. Popovic JR, Kozak LJ. National hospital discharge survey: annual summary, 1998. Vital and Health Stat. 2000;13:1-194.
2. Hunskaar S, Burgio K, Clark A. Epidemiology of urinary and fecal incontinence and pelvic organ prolapse. In: Abrams P, Cordozo L, Khoury S, Wein A, eds. Third International Consultation on Incontinence. 1st ed. Paris: Health Publication Ltd.; 2005.
3. Swift S, Woodman P, O'Boyle A, et al. Pelvic Organ Support Study (POSST): the distribution, clinical definition, and epidemiologic condition of pelvic organ support defects. Am J Obstet Gynecol. 2005;192:795-806.
4. Nygaard I, Bradley C, Brandt D. Pelvic organ prolapse in older women: prevalence and risk factors. Obstet Gynecol. 2004;104:489-497.
5. Cooke PS, Uchima FD, Fujii DK, Bern HA, Cunha GR. Restoration of normal morphology and estrogen responsiveness in cultured vaginal and uterine epithelia transplanted with stroma. Proc Natl Acad Sci USA. 1986;83:2109-2113.
6. Bercovici B, Uretzki G, Palti Y. The effects of estrogens on cytology and vascularization of the vaginal epithelium in climacteric women. Am J Obstet Gynecol. 1972;113:98-103.
7. Diwadkar GB, Barber MD, Feiner B, Maher C, Jelovsek JE. Complication and reoperation rates after apical vaginal prolapse surgical repair: a systematic review. Obstet Gynecol. 2009;113:367-373.
8. Fialkow MF, Newton KM, Weiss NS. Incidence of recurrent pelvic organ prolapse 10 years following primary surgical management: a retrospective cohort study. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19:1483-1487.
9. Denman MA, Gregory WT, Boyles SH, Smith V, Edwards SR, Clark AL. Reoperation 10 years after surgically managed pelvic organ prolapse and urinary incontinence. Am J Obstet Gynecol. 2008;198:555 e551-e555.
10. Bachmann G, Bouchard C, Hoppe D, et al. Efficacy and safety of low-dose regimensof conjugated estrogens cream administered vaginally. Menopause. 2009;16:719-727.
11. Freedman M, Kaunitz AM, Reape KZ, Hait H, Shu H. Twice-weekly synthetic conjugated estrogens vaginal cream for the treatment of vaginal atrophy. Menopause. 2009;16:735-741.
12. Vaccaro CM, Mutema GK, Fellner AN, et al. Histologic and cytologic effects of vaginal estrogen in women with pelvic organ prolapse: a randomized controlled trial. Female Pelvic Med Reconstr Surg. 2013;19:34-39.
13. Manonai J, Theppisai U, Suthutvoravut S, Udomsubpayakul U, Chittacharoen A. The effect of estradiol vaginal tablet and conjugated estrogen cream on urogenital symptoms in postmenopausal women: a comparative study. J Obstet Gynaecol Res. 2001;27:255-260.
14. Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA. Morphometric properties of the posterior vaginal wall in women with pelvic organ prolapse. Am J Obstet Gynecol. 2002;187:1501-1508; discussion 1508-1509.
15. Havelock JC, Keller P, Muleba N, et al. Human myometrial gene expression before and during parturition. Biol Reprod. 2005;72:707-719.
16. Miller EJ, Rhodes RK. Preparation and characterization of the different types of collagen. Methods Enzymol. 1982;82:33-64.
17. Wieslander CK, Marinis SI, Drewes PG, Keller PW, Acevedo JF, Word RA. Regulation of elastolytic proteases in the mouse vagina during pregnancy, parturition, and puerperium. Biol Reprod. 2008;78:521-528.
18. Nelson RE, Grebe SK, O'Kane DJ, Singh RJ. Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasma. Clin Chem. 2004;50:373-384.
19. Balgobin S, Montoya TI, Shi H, et al. Estrogen alters remodeling of the vaginal wall after surgical injury in guinea pigs. Biol Reprod. 2013;89:138.
20. Slayden OD, Hettrich K, Carroll RS, Otto LN, Clark AL, Brenner RM. Estrogen enhances cystatin C expression in the macaque vagina. J Clin Endocrinol Metab. 2004;89:883-891.
21. Dorr MB, Nelson AL, Mayer PR, et al. Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis. Fertil Steril. 2010;94:2365-2368.
22. Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA. 2006;296:2563-2571.
23. Minkin MJ, Maamari R, Reiter S. Improved compliance and patient satisfaction with estradiol vaginal tablets in postmenopausal women previously treated with another local estrogen therapy. Int J Womens Health. 2013;5:133-139.
24. Wu JM, Vaughan CP, Goode PS, et al. Prevalence and trends of symptomatic pelvic floor disorders in US women. Obstet Gynecol. 2014;123:141-148.