Knockdown of p66Shc by siRNA injection rescues arsenite-induced developmental retardation in mouse preimplantation embryos

Reproductive Toxicology

Volumn 43, Issue , 2014, Pages 8-18

  Ren, Kai ^a,b,c   Li, Xiaoqiao ^a,b,c   Yan, Jinting ^a,b,c   Huang, Guoying ^d   Zhou, Shiyi ^a,b,c   Yang, Baiqing ^a,b,c   Ma, Xu ^a,b,c   Lu, Cailing ^a,b,c  

^a GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^b NATIONAL RESEARCH INSTITUTE FOR FAMILY PLANNING   (China)

^c World Health Organizations   (China)

^d CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Arsenite; Embryo arrest; Pronuclear microinjection; Reactive oxygen species; SiRNA

Indexed keywords

ARSENIC TRIOXIDE; MESSENGER RNA; P66SHC SMALL INTERFERING RNA; PROTEIN P66; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; FEMALE; GROWTH RETARDATION; IN VITRO STUDY; MALE; MICROINJECTION; MORULA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PREIMPLANTATION EMBRYO; PRONUCLEUS; ZYGOTE;

EID: 84907598223     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2013.10.008     Document Type: Article

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