Chronic administration of haloperidol and clozapine induces differential effects on the expression of Arc and c-Fos in rat brain

Journal of Psychopharmacology

Volumn 28, Issue 10, 2014, Pages 947-954

  Collins, Cheryl M ^a,c   Wood, Martyn D ^b,d   Elliott, J Martin ^a  

^a DE MONTFORT UNIVERSITY   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

^d UCB PHARMA   (Belgium)

Author keywords

Antipsychotic; Arc; Brain; Chronic; Rat

Indexed keywords

ACTIVITY REGULATED CYTOSKELETAL-ASSOCIATED PROTEIN; CLOZAPINE; CYTOSKELETON PROTEIN; HALOPERIDOL; NERVE PROTEIN; NEUROLEPTIC AGENT; PROTEIN C FOS;

ANIMAL; BIOSYNTHESIS; BRAIN; CINGULATE GYRUS; CORPUS STRIATUM; DRUG EFFECTS; GENE EXPRESSION REGULATION; MALE; METABOLISM; NUCLEUS ACCUMBENS; RAT; SEPTUM PELLUCIDUM; TIME;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; CLOZAPINE; CORPUS STRIATUM; CYTOSKELETAL PROTEINS; GENE EXPRESSION REGULATION; GYRUS CINGULI; HALOPERIDOL; MALE; NERVE TISSUE PROTEINS; NUCLEUS ACCUMBENS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; SEPTUM OF BRAIN; TIME FACTORS;

EID: 84907569908     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881114536788     Document Type: Article

References (40)

1. De Bartolomeis A, Marmo F, Filomena Buonaguro E, et al (2013) Imaging brain gene expression profiles by antipsychotics: Region-specific action of amisulpride on postsynaptic density transcripts compared to haloperidol. Eur Neuropsychopharmacol 23:1516-1529.
2. De Bartolomeis A and Tomasetti C (2012) Calcium-dependent networks in dopamine-glutamate interaction: the role of postsynaptic scaffolding proteins. Mol Neurobiol 46:275-296.
3. Beique JC, Na Y, Kuhl D, et al (2011) Arc-dependent synapse-specific homeostatic plasticity. Proc Natl Acad Sci USA 108:816-821.
4. Beveridge TJ, Mechan AO, Sprakes M, et al (2004) Effect of 5-HT depletion by MDMA on hyperthermia and Arc mRNA induction in rat brain. Psychopharmacology 173:346-352.
5. Broberg BV, Glenthøj BY, Dias R, et al (2009) Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia-sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology 206:631-640.
6. Bruins Slot LA, Lestienne F, Grevoz-Barret C, et al (2009) F15063, a potential antipsychotic with dopamine D (2)/D (3) receptor antagonist and 5-HT (1A) receptor agonist properties: influence on immediateearly gene expression in rat prefrontal cortex and striatum. Eur J Pharmacol 620:27-35.
7. Dragunow M, Robertson GS, Faull RL, et al (1990) D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons. Neuroscience 37:287-294.
8. Featherstone RE and McDonald RJ (2005) Lesions of the dorsolateral or dorsomedial striatum impair performance of a previously acquired simple discrimination task. Neurobiol Learn Mem 84:159-167.
9. Fumagalli F, Frasca A, Racagni G, et al (2009) Antipsychotic drugs modulate Arc expression in the rat brain. Eur Neuropsychopharmacol 19:109-115.
10. Harrison PJ and Weinberger DR (2005) Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10:40-68.
11. Hiroi N and Graybiel AM (1996) Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum. J Comp Neurol 374:70-83.
12. Horner KA, Noble ES and Gilbert YE (2010) Methamphetamineinduced stereotypy correlates negatively with patch-enhanced prodynorphin and arc mRNA expression in the rat caudate putamen: the role of mu opioid receptor activation. Pharmacol Biochem Behav 95:410-421.
13. Huang N, Ase AR, Hebert C, et al (1997) Effects of chronic neuroleptic treatments on dopamine D1 and D2 receptors: homogenate binding and autoradiographic studies. Neurochem Int 30:277-290.
14. Iasevoli F, Tomasetti C, Marmo F, et al (2010) Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindole. Psychopharmacology 212:29-344.
15. Iasevoli F, Ambesi-Impiombato A, Fiore G, et al (2011) Pattern of acute induction of Homer1a gene is preserved after chronic treatment with first- and second-generation antipsychotics: effect of short-term drug discontinuation and comparison with Homer1a-interacting genes. J Psychopharmacol 25:875-887.
16. Jardemark K, Marcus MM, Malmerfelt A, et al (2012) Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission. Psychopharmacology 221:115-131.
17. Jennings CA, Cluderay JE, Gartlon J, et al (2006) The effects of ziprasidone on regional c-Fos expression in the rat forebrain. Psychopharmacology 184:13-20.
18. Kantrowitz J and Javitt DC (2012) Glutamatergic transmission in schizophrenia: from basic research to clinical practice. Curr Opin Psychiatry 25:96-102.
19. Molteni R, Calabrese F, Racagni G, et al (2009) Antipsychotic drug actions on gene modulation and signaling mechanisms. Pharmacol Ther 124:74-85.
20. Nakahara T, Kuroki T, Hashimoto K, et al (2000) Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain. Neuroreport 11:551-555.
21. Nguyen TV, Kosofsky BE, Birnbaum R, et al (1992) Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine. Proc Natl Acad Sci USA 89:4270-4274.
22. Nonaka M, Fujii H, Kim R, et al (2014) Untangling the two-way signalling route from synapses to the nucleus, and from the nucleus back to the synapses. Philos Trans R Soc Lond B Biol Sci 369:1471-2970.
23. Nord M and Farde L (2011) Antipsychotic occupancy of dopamine receptors in schizophrenia. CNS Neurosci Ther 17:97-103.
24. Paxinos G and Watson C (2005). The Rat Brain in Stereotaxic Coordinates. Amsterdam; Elsevier Academic Press.
25. Pei Q, Zetterstrom TS, Sprakes M, et al (2003) Antidepressant drug treatment induces Arc gene expression in the rat brain. Neuroscience 121:975-982.
26. Robbins MJ, Critchlow HM, Lloyd A, et al (2008) Differential expression of IEG mRNA in rat brain following acute treatment with clozapine or haloperidol: a semi-quantitative RT-PCR study. J Psychopharmacol 22:536-542.
27. Robertson GS, Matsumura H and Fibiger HC (1994) Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity. J Pharmacol Exp Ther 271:1058-1066.
28. Samaha AN, Seeman P, Stewart J, et al (2007) "Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time. J Neurosci 27:2979-2986.
29. Sebens JB, Koch T, Ter Horst GJ, et al (1995) Differential Fos-protein induction in rat forebrain regions after acute and long-term haloperidol and clozapine treatment. Eur J Pharmacol 273:175-182.
30. 2-adrenoceptor antagonist/5-HT-noradrenaline reuptake inhibitor (SNRI), S35966, compared to the SNRI, venlafaxine. Int J Neuropsychopharmacol 15:617-629.
31. Shepherd JD and Bear MF (2011) New views of Arc, a master regulator of synaptic plasticity. Nature Neurosci 14:279-284.
32. Shepherd JD, Rumbaugh G, Wu J, et al (2006) Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron 52:475-484.
33. Snyder MA and Gao WJ (2013) NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia. Front Cell Neurosci 7:31. doi: 10.3389/fncel.2013.00031
34. Southam E, Cilia J, Gartlon JE, et al (2009) Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040. Psychopharmacology 201:483-494.
35. Sun YJ, Suzuki M, Kurachi T, et al (1998) Expression of Fos protein in the limbic regions of the rat following haloperidol decanoate. Brain Res 791:125-136.
36. Tarazi FI, Florijn WJ and Creese I (1997) Differential regulation of dopamine receptors after chronic typical and atypical antipsychotic drug treatment. Neuroscience 78:985-996.
37. Turrone P, Remington G, Kapur S, et al (2003) Differential effects of within-day continuous vs.transient dopamine D2 receptor occupancy in the development of vacuous chewing movements (VCMs) in rats. Neuropsychopharmacology 28:1433-1439.
38. Wan W, Ennulat DJ and Cohen BM (1995) Acute administration of typical and atypical antipsychotic drugs induces distinctive patterns of Fos expression in the rat forebrain. Brain Res 688:95-104.
39. Wang MJ, Li YC, Snyder MA, et al (2013) Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons. PLoS ONE 8:e61787 doi: 10.1371/journal.pone.0061787).
40. Zahm DS (2000) An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neurosci Biobehav Rev 24:85-105