A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes

Biochemical and Biophysical Research Communications

Volumn 452, Issue 3, 2014, Pages 665-668

  Okudaira, Noriyuki ^a   Kuwahara, Masayoshi ^b   Hirata, Yutaka ^a   Oku, Yoshitaka ^a   Nishio, Hajime ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Arrhythmia; Calcium; Model mouse; Sudden death

Indexed keywords

ADRENALIN; CAFFEINE; CARDIOTONIC AGENT; RYANODINE RECEPTOR 2; CALCIUM; RYANODINE RECEPTOR; RYANODINE RECEPTOR 2. MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; CADAVER; CALCIUM SIGNALING; CONTROLLED STUDY; DEPOLARIZATION; ELECTROCARDIOGRAM; HEART DISEASE; HEART MUSCLE CELL; MOUSE; NONHUMAN; PHENOTYPE; SUDDEN DEATH; TELEMETRY; ACTION POTENTIAL; AMINO ACID SUBSTITUTION; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION; GENE TARGETING; GENETICS; HEART ARRHYTHMIA; ION TRANSPORT; MALE; METABOLISM; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PRIMARY CELL CULTURE; PROTEIN TERTIARY STRUCTURE;

ACTION POTENTIALS; AMINO ACID SUBSTITUTION; ANIMALS; ARRHYTHMIAS, CARDIAC; CAFFEINE; CALCIUM; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; EPINEPHRINE; GENE EXPRESSION; GENE KNOCK-IN TECHNIQUES; ION TRANSPORT; MALE; MICE; MUTATION; MYOCYTES, CARDIAC; PRIMARY CELL CULTURE; PROTEIN STRUCTURE, TERTIARY; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 84907545979     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.08.132     Document Type: Article

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