A CREB1–TGFβ2 self-sustaining loop in glioblastoma

Cancer Discovery

Volumn 4, Issue 10, 2014, Pages 1123-1125

  Wotton, David ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA2; CREB1 PROTEIN, HUMAN;

ARTICLE; CANCER GROWTH; CYCLIC AMP RESPONSIVE ELEMENT; GENE EXPRESSION; GENE MUTATION; GLIOBLASTOMA; HUMAN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; AUTOCRINE EFFECT; METABOLISM;

ANIMALS; AUTOCRINE COMMUNICATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GLIOBLASTOMA; HUMANS; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84907520173     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-14-0861     Document Type: Article

References (10)

1. Tanaka S, Louis DN, Curry WT, Batchelor TT, Dietrich J. Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end? Nat Rev Clin Oncol 2013; 10: 14-26.
2. Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, et al. The somatic genomic landscape of glioblastoma. Cell 2013; 155: 462-77.
3. Roy LO, Poirier MB, Fortin D. Transforming growth factor-beta and its implication in the malignancy of gliomas. Target Oncol 2014 Mar 5. [Epub ahead of print].
4. Massague J. TGFbeta in cancer. Cell 2008; 134: 215-30.
5. Anido J, Saez-Borderias A, Gonzalez-Junca A, Rodon L, Folch G, Carmona MA, et al. TGF-beta receptor inhibitors target the CD44(high)/ Id1(high) glioma-initiating cell population in human glioblastoma. Cancer Cell 2010; 18: 655-68.
6. Rodón L, Gonzàlez-Juncà A, del Mar Inda M, Sala-Hojman A, Martínez-Sáez E, Seoane J. Active CREB1 promotes a malignant TGFβ2 autocrine loop in glioblastoma. Cancer Discov 2014;4: 1230–41.
7. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation- dependent factor CREB. Nat Rev Mol Cell Biol 2001; 2: 599–609.
8. Mantamadiotis T, Papalexis N, Dworkin S. CREB signalling in neural stem/progenitor cells: recent developments and the implications for brain tumour biology. Bioessays 2012; 34: 293-300.
9. Kang Y, Chen CR, Massague J. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 2003; 11: 915-26.
10. Bruna A, Darken RS, Rojo F, Ocana A, Penuelas S, Arias A, et al. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 2007; 11: 147-60.