Neuro-cognitive functioning in unaffected siblings of patients with bipolar disorder: Comparison with bipolar patients and healthy controls

Indian Journal of Psychiatry

Volumn 56, Issue 3, 2014, Pages 283-288

  Nehra, Ritu ^a   Grover, Sandeep ^a   Sharma, Sunil ^a   Sharma, Aditi ^a   Sarkar, Siddharth ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Bipolar disorder; cognitive functions; endophenotype; unaffected siblings

Indexed keywords

ADULT; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; BRIEF VISUOSPATIAL MEMORY TEST REVISED; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; HOPKINS VERBAL LEARNING TEST REVISED; HUMAN; INTELLIGENCE TEST; LEARNING TEST; MALE; MENTAL CONCENTRATION; MOTOR PERFORMANCE; PSYCHOMOTOR PERFORMANCE; SIBLING; SPATIAL MEMORY TEST; VERBAL MEMORY; VISUAL MEMORY; WECHSLER ADULT INTELLIGENCE SCALE DIGIT SYMBOL TEST; WISCONSIN CARD SORTING TEST;

EID: 84907501839     PISSN: 00195545     EISSN: 19983794     Source Type: Journal    
DOI: 10.4103/0019-5545.140645     Document Type: Article

References (21)

1. Gottesman II, Gould TD. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry 2003;160: 636-45
2. Mann-Wrobel MC, Carreno JT, Dickinson D. Meta-Analysis of neuropsychological functioning in euthymic bipolar disorder: An update and investigation of moderator variables. Bipolar Disord 2011;13: 334-42
3. Robinson LJ, Thompson JM, Gallagher P, Goswami U, Young AH, Ferrier IN, et al. A meta-Analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord 2006;93: 105-15
4. Torres IJ, Boudreau VG, Yatham LN. Neuropsychological functioning in euthymic bipolar disorder: A meta-Analysis. Acta Psychiatr Scand Suppl 2007;434: 17-26
5. Bora E, Yucel M, Pantelis C. Cognitive endophenotypes of bipolar disorder: A meta-Analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord 2009;113: 1-20
6. Glahn DC, Bearden CE, Niendam TA, Escamilla MA. The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder. Bipolar Disord 2004;6: 171-82
7. Arts B, Jabben N, Krabbendam L, van Os J. Meta-Analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med 2008;38: 771-85
8. Clark L, Kempton MJ, Scarnà A, Grasby PM, Goodwin GM. Sustained attention-deficit confirmed in euthymic bipolar disorder but not in firstdegree relatives of bipolar patients or euthymic unipolar depression. Biol Psychiatry 2005;57: 183-7
9. Doyle AE, Wozniak J, Wilens TE, Henin A, Seidman LJ, Petty C, et al. Neurocognitive impairment in unaffected siblings of youth with bipolar disorder. Psychol Med 2009;39: 1253-63
10. Frantom LV, Allen DN, Cross CL. Neurocognitive endophenotypes for bipolar disorder. Bipolar Disord 2008;10: 387-99
11. Szöke A, Schürhoff F, Golmard JL, Alter C, Roy I, Méary A, et al. Familial resemblance for executive functions in families of schizophrenic and bipolar patients. Psychiatry Res 2006;144: 131-8
12. Trivedi JK, Goel D, Dhyani M, Sharma S, Singh AP, Sinha PK, et al. Neurocognition in first-degree healthy relatives (siblings) of bipolar affective disorder patients. Psychiatry Clin Neurosci 2008;62: 190-6
13. Pattanayak RD, Sagar R, Mehta M. Neurocognition in unaffected first-degree relatives of patients with bipolar disorder type I from India a potential vulnerability marker? Sage Open 2012;2
14. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23: 56-62
15. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: Reliability, validity and sensitivity. Br J Psychiatry 1978;133: 429-35
16. Heaton RK. Wisconsin Card Sorting Test: Computerized Version 4 (WCST: CV4). Florida: Psychological Assessment Resources; 2003
17. Benedict RH. Brief Visuospatial Memory Test-Revised. Odessa, Florida: Psychological Assessment Resources; 1997
18. Benedict RH, Schretlen D, Groninger L, Brandt J. Hopkins verbal learning test-Revised: Normative data and analysis of inter-form and test-retest reliability. Clin Neuropsychol 1998;12: 43-55
19. Psychological Corporation. Wechsler Adult Intelligence Scale. 3rd ed. San Antonio, TX: Psychological Corporation; 1998
20. Balanzá-Martínez V, Rubio C, Selva-Vera G, Martinez-Aran A, Sánchez-Moreno J, Salazar-Fraile J, et al. Neurocognitive endophenotypes (endophenocognitypes) from studies of relatives of bipolar disorder subjects: A systematic review. Neurosci Biobehav Rev 2008;32: 1426-38
21. Kulkarni S, Jain S, Janardhan Reddy YC, Kumar KJ, Kandavel T. Impairment of verbal learning and memory and executive function in unaffected siblings of probands with bipolar disorder. Bipolar Disord 2010;12: 647-56