Electronic medication packaging devices and medication adherence: A systematic review

JAMA - Journal of the American Medical Association

Volumn 312, Issue 12, 2014, Pages 1237-1247

  Checchi, Kyle D ^a   Huybrechts, Krista F ^a   Avorn, Jerry ^a   Kesselheim, Aaron S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; CANDESARTAN; CINACALCET; CLOPIDOGREL; FLUTICASONE PROPIONATE; HYDROCHLOROTHIAZIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; IPRATROPIUM BROMIDE; IRBESARTAN; LERCANIDIPINE; LITHIUM SALT; METFORMIN; NEUROLEPTIC AGENT; PILOCARPINE; STEROID; SULFONYLUREA DERIVATIVE; TELMISARTAN; TRAVOPROST; PRESCRIPTION DRUG;

ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; COST BENEFIT ANALYSIS; DATA ANALYSIS; DIABETES MELLITUS; ELECTRONIC MEDICATION PACKAGING DEVICE; ELECTRONICS; GLAUCOMA; HEALTH CARE SYSTEM; HEART FAILURE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERGLYCEMIA; HYPERLIPIDEMIA; HYPERPARATHYROIDISM; HYPERTENSION; INFLAMMATORY BOWEL DISEASE; INFORMATION PROCESSING; KIDNEY GRAFT; MEDICATION COMPLIANCE; MENTAL DISEASE; META ANALYSIS; PACKAGING MATERIAL; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SMOKING CESSATION; SYSTEMATIC REVIEW; THROMBOCYTE; DRUG PACKAGING; MEDICAL INFORMATICS; REMINDER SYSTEM;

DRUG PACKAGING; ELECTRONICS; HUMANS; MEDICAL INFORMATICS; MEDICATION ADHERENCE; PRESCRIPTION DRUGS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REMINDER SYSTEMS;

EID: 84907487893     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2014.10059     Document Type: Review

References (60)

1. Cramer JA, Roy A, Burrell A, et al. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44-47.
2. Zullig LL, Peterson ED, Bosworth HB. Ingredients of successful interventions to improve medication adherence. JAMA. 2013;310(24):2611-2612.
3. Fischer MA, Stedman MR, Lii J, et al. Primary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med. 2010;25(4):284-290.
4. Muntner P, Halanych JH, Reynolds K, et al. Low medication adherence and the incidence of stroke symptoms among individuals with hypertension: the REGARDS study. J Clin Hypertens (Greenwich). 2011;13(7):479-486.
5. Holstad MMD, Diiorio C, McCarty F. Adherence, sexual risk, and viral load in HIV-infected women prescribed antiretroviral therapy. AIDS Patient Care STDS. 2011;25(7):431-438.
6. Fitzgerald AA, Powers JD, Ho PM, et al. Impact of medication nonadherence on hospitalizations and mortality in heart failure. J Card Fail. 2011;17(8):664-669.
7. Goldberg DE, Siliciano RF, Jacobs WR Jr. Outwitting evolution: fighting drug-resistant TB, malaria, and HIV. Cell. 2012;148(6):1271-1283.
8. Bowry ADK, Shrank WH, Lee JL, Stedman M, Choudhry NK. A systematic review of adherence to cardiovascular medications in resource-limited settings. J Gen Intern Med. 2011;26(12):1479-1491.
9. Sabaté E. Adherence to Long-term Therapies: Evidence for Action. World Health Organization website. http://whqlibdoc.who.int/publications/2003/9241545992.pdf. Published January 2003. Accessed January 25, 2014.
10. Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008;2(2):CD000011.
11. Naditz A. Medication compliance - helping patients through technology: modern "smart" pillboxes keep memory-short patients on their medical regimen. Telemed J E Health. 2008;14(9):875-880.
12. Granger BB, Bosworth HB. Medication adherence: emerging use of technology. Curr Opin Cardiol. 2011;26(4):279-287.
13. Misono AS, Cutrona SL, Choudhry NK, et al. Healthcare information technology interventions to improve cardiovascular and diabetes medication adherence. Am J Manag Care. 2010;16(12)(suppl HIT):SP82-SP92.
14. Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. http://www.handbook.cochrane.org. 2011. Accessed January 25, 2014.
15. Barrios V, Escobar C, Navarro Á, Calderón A, Ruilope LM. Antihypertensive effectiveness of lercanidipine administered using an electronic pillbox compared with usual care in a cohort of mild-to-moderately hypertensive patients: the ELECTRA study. Therapy. 2007;4(4):433-440.
16. Wagner GJ, Ghosh-Dastidar B. Electronic monitoring: adherence assessment or intervention? HIV Clin Trials. 2002;3(1):45-51.
17. Christensen A, Christrup LL, Fabricius PE, et al. The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial. J Hypertens. 2010;28(1):194-200.
18. Kooy MJ, van Wijk BLG, Heerdink ER, de Boer A, Bouvy ML. Does the use of an electronic reminder device with or without counseling improve adherence to lipid-lowering treatment? the results of a randomized controlled trial. Front Pharmacol. 2013;4:69.
19. Charles T, Quinn D, Weatherall M, Aldington S, Beasley R, Holt S. An audiovisual reminder function improves adherence with inhaled corticosteroid therapy in asthma. J Allergy Clin Immunol. 2007;119(4):811-816.
20. Holló G, Kothy P. Can adherence to topical glaucoma medication be improved by using an audible alarm? a pilot study. Pharm Med. 2008;22(3):175-179.
21. McKenney JM, Munroe WP, Wright JT Jr. Impact of an electronic medication compliance aid on long-term blood pressure control. J Clin Pharmacol. 1992;32(3):277-283.
22. Santschi V, Wuerzner G, Schneider MP, Bugnon O, Burnier M. Clinical evaluation of IDAS II, a new electronic device enabling drug adherence monitoring. Eur J Clin Pharmacol. 2007;63(12):1179-1184.
23. Laster SF, Martin JL, Fleming JB. The effect of a medication alarm device on patient compliance with topical pilocarpine. J Am Optom Assoc. 1996;67(11):654-658.
24. Vervloet M, Santen-Reestman J, Vlijmen B, et al. Een oplettend medicijndoosje voor diabetes type 2 patiënten: Een onderzoek naar de effecten van real-time medication monitoring. Netherlands Institute for Health Services Research website. http://www.nivel.nl/sites/default/files/bestanden/Rapport-oplettend-medicijndoosje.pdf. Published June 2010. Accessed January 25, 2014.
25. Vervloet M, van Dijk L, Santen-Reestman J, van Vlijmen B, Bouvy ML, de Bakker DH. Improving medication adherence in diabetes type 2 patients through Real Time Medication Monitoring: a randomised controlled trial to evaluate the effect of monitoring patients' medication use combined with short message service (SMS) reminders. BMC Health Serv Res. 2011;11(5):5. doi:10.1186/1472-6963-11-5.
26. Vervloet M, van Dijk L, de Bakker DH, et al. Short- and long-term effects of real-time medication monitoring with short message service (SMS) reminders for missed doses on the refill adherence of people with type 2 diabetes: evidence from a randomized controlled trial. Diabet Med. 2014;31(7):821-828. doi:10.1111/dme.12439.
27. van Onzenoort HAW, Verberk WJ, Kroon AA, et al. Electronic monitoring of adherence, treatment of hypertension, and blood pressure control. Am J Hypertens. 2012;25(1):54-59.
28. Murray MD, Young JM, Morrow DG, et al. Methodology of an ongoing, randomized, controlled trial to improve drug use for elderly patients with chronic heart failure. Am J Geriatr Pharmacother. 2004;2(1):53-65.
29. Murray MD, Young J, Hoke S, et al. Pharmacist intervention to improve medication adherence in heart failure: a randomized trial. Ann Intern Med. 2007;146(10):714-725.
30. Tashkin DP, Rand C, Nides M, et al. A nebulizer chronolog to monitor compliance with inhaler use. Am J Med. 1991;91(4A):33S-36S.
31. Nides MA, Tashkin DP, Simmons MS, Wise RA, Li VC, Rand CS. Improving inhaler adherence in a clinical trial through the use of the nebulizer chronolog. Chest. 1993;104(2):501-507.
32. de Bruin M. An electronic-monitoring based intervention improves HIV treatment adherence [abstract]. J Int Assoc Physicians AIDS Care (Chic). 2010;9(4):255.
33. de Bruin M, Hospers HJ, van Breukelen GJP, Kok G, Koevoets WM, Prins JM. Electronic monitoring-based counseling to enhance adherence among HIV-infected patients: a randomized controlled trial. Health Psychol. 2010;29(4):421-428.
34. Wu JR, Corley DJ, Lennie TA, Moser DK. Effect of a medication-taking behavior feedback theory-based intervention on outcomes in patients with heart failure. J Card Fail. 2012;18(1):1-9.
35. Elixhauser A, Eisen SA, Romeis JC, Homan SM. The effects of monitoring and feedback on compliance. Med Care. 1990;28(10):882-893.
36. Sabin LL, DeSilva MB, Hamer DH, et al. Using electronic drug monitor feedback to improve adherence to antiretroviral therapy among HIV-positive patients in China. AIDS Behav. 2010;14(3):580-589.
37. Mooney ME, Sayre SL, Hokanson PS, Stotts AL, Schmitz JM. Adding MEMS feedback to behavioral smoking cessation therapy increases compliance with bupropion: a replication and extension study. Addict Behav. 2007;32(4):875-880.
38. Rigsby MO, Rosen MI, Beauvais JE, et al. Cue-dose training with monetary reinforcement: pilot study of an antiretroviral adherence intervention. J Gen Intern Med. 2000;15(12):841-847.
39. Forni Ogna V, Wuerzner G, Menetrey I, et al. Influence of adherence monitoring program on long-term platelet inhibition by clopidogrel: results of a randomized controlled trial [abstract]. Circulation. 2012;126:A17116.
40. Schmitz JM, Sayre SL, Stotts AL, Rothfleisch J, Mooney ME. Medication compliance during a smoking cessation clinical trial: a brief intervention using MEMS feedback. J Behav Med. 2005;28(2):139-147.
41. Cramer JA, Rosenheck R. Enhancing medication compliance for people with serious mental illness. J Nerv Ment Dis. 1999;187(1):53-55.
42. Matsuyama JR, Mason BJ, Jue SG. Pharmacists' interventions using an electronic medication-event monitoring device's adherence data versus pill counts. Ann Pharmacother. 1993;27(7-8):851-855.
43. Kozuki Y, Schepp KG. Visual-feedback therapy for antipsychotic medication adherence. Int Clin Psychopharmacol. 2006;21(1):57-61.
44. Kruse W, Rampmaier J, Ullrich G, Weber E. Patterns of drug compliance with medications to be taken once and twice daily assessed by continuous electronic monitoring in primary care. Int J Clin Pharmacol Ther. 1994;32(9):452-457.
45. Kozuki Y, Poupore E, Schepp K. Visual feedback therapy to enhance medication adherence in psychosis. Arch Psychiatr Nurs. 2005;19(2):70-80.
46. Onyirimba F, Apter A, Reisine S, et al. Direct clinician-to-patient feedback discussion of inhaled steroid use: its effect on adherence. Ann Allergy Asthma Immunol. 2003;90(4):411-415.
47. Russell CL, Conn VS, Ashbaugh C, Coffey D, Wakefield M. A pilot RCT to increase medication adherence in transplantation. Am J Transplant. 2010;10(s4):376. doi:10.1111/j.1600-6143.2010.03108.x.
48. Russell C, Conn V, Ashbaugh C, et al. Taking immunosuppressive medications effectively (TIMELink): a pilot randomized controlled trial in adult kidney transplant recipients. Clin Transplant. 2011;25(6):864-870.
49. Waeber B, Vetter W, Darioli R, Keller U, Brunner HR. Improved blood pressure control by monitoring compliance with antihypertensive therapy. Int J Clin Pract. 1999;53(1):37-38.
50. Matteson M. A Pilot Intervention to Improve Medication Adherence in Nonadherent Inflammatory Bowel Disease Patients [dissertation]. Columbia: University of Missouri; 2011.
51. Okeke CO, Quigley HA, Jampel HD, et al. Interventions improve poor adherence with once daily glaucoma medications in electronically monitored patients. Ophthalmology. 2009;116(12):2286-2293.
52. Davies S, Asghar S, Cooper V, et al. Does feedback of medication execution using MEMS caps aid adherence to HAART? the MEMRI study (MEMS as Realistic Intervention). J Int AIDS Soc. 2010;13(suppl 4):120.
53. Mengden T, Vetter H, Tousset E, Uen S. Management of patients with uncontrolled arterial hypertension-the role of electronic compliance monitoring, 24-h ambulatory blood pressure monitoring and candesartan/HCTZ. BMC Cardiovasc Disord. 2006;6:36. doi:10.1186/1471-2261-6-36.
54. Forni Ogna V, Pruijm M, Zweiacker C, et al. Clinical benefits of an adherence monitoring program in the management of secondary hyperparathyroidism with cinacalcet: results of a prospective randomized controlled study [published online July 18, 2013]. BioMed Res Int. doi:10.1155/2013/104892.
55. de Bruin M, Hospers HJ, van den Borne HW, Kok G, Prins JM. Theory- and evidence-based intervention to improve adherence to antiretroviral therapy among HIV-infected patients in the Netherlands: a pilot study. AIDS Patient Care STDS. 2005;19(6):384-394.
56. Ruppar TM. Pilot study of a feedback intervention to improve medication adherence in older adults with hypertension [abstract]. Eur J Cardiovasc Nurs. 2010;9(suppl 1):S26.
57. Ruppar TM. Randomized pilot study of a behavioral feedback intervention to improve medication adherence in older adults with hypertension. J Cardiovasc Nurs. 2010;25(6):470-479.
58. Rosen MI, Rigsby MO, Salahi JT, Ryan CE, Cramer JA. Electronic monitoring and counseling to improve medication adherence. Behav Res Ther. 2004;42(4):409-422.
59. Hedges L, Olkin I. Statistical Methods for Meta-analysis. Boston, MA: Academic Press; 1985.
60. Mazor KM, Beard RL, Alexander GL, et al. Patients' and family members' views on patient-centered communication during cancer care. Psychooncology. 2013;22(11):2487-2495.