Human trefoil factor 2 is a lectin that binds α-GlNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori

Journal of Biological Chemistry

Volumn 289, Issue 40, 2014, Pages 27363-27375

  Hnisch, Franz Georg ^a   Bonar, David ^a   Schloerer, Nils ^b   Schroten, Horst ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CELL SIGNALING; CHEMICAL COMPOUNDS; ISOMERS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYSACCHARIDES; REPAIR;

ANTIBIOTIC ACTIVITY; FUNCTIONAL RELATIONSHIP; GASTROINTESTINAL TRACT; HELICOBACTER PYLORI; HELICOBACTER PYLORI INFECTIONS; NATURAL ANTIBIOTICS; PORCINE STOMACH MUCINS; STRUCTURAL ASSIGNMENTS;

PROTEINS;

ALDITOL; ALPHA 1,4 N ACETYLGLUCOSAMINE; GLUCOSAMINE DERIVATIVE; INTESTINAL TREFOIL FACTOR; INTESTINAL TREFOIL FACTOR 2; MUCIN 6; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; MUC6 PROTEIN, HUMAN; N ACETYLGLUCOSAMINE; PEPTIDE; POLYSACCHARIDE; PROTEIN BINDING; TREFOIL FACTOR;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; EMBRYO; ENZYME INHIBITION; ENZYME SPECIFICITY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; LINKAGE ANALYSIS; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM; ANIMAL; CARBOHYDRATE ANALYSIS; CHEMISTRY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; SWINE;

ACETYLGLUCOSAMINE; ANIMALS; CARBOHYDRATE SEQUENCE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MOLECULAR SEQUENCE DATA; MUCIN-6; PEPTIDES; POLYSACCHARIDES; PROTEIN BINDING; SWINE;

EID: 84907482413     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.597757     Document Type: Article

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