Insertion sequence transposition determines imipenem resistance in Acinetobacter baumannii

Microbial Drug Resistance

Volumn 20, Issue 5, 2014, Pages 410-415

  Kuo, Han Yueh ^a,b   Chang, Kai Chih ^c   Liu, Chih Chin ^d,e   Tang, Chuan Yi ^e,f   Peng, Jhih Hua ^c   Lu, Chia Wei ^f   Tu, Chi Chao ^g,h   Liou, Ming Li ^e,h  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c TZU CHI UNIVERSITY   (Taiwan)

^d CHUNG HUA UNIVERSITY   (Taiwan)

^e PROVIDENCE UNIVERSITY   (Taiwan)

^f NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^g KEELUNG HOSPITAL   (Taiwan)

^h YUANPEI UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; CARBAPENEM; CEFEPIME; CIPROFLOXACIN; COTRIMOXAZOLE; IMIPENEM; MEROPENEM; SULTAMICILLIN; TRANSPOSASE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEMASE; RNA 16S; TRANSPOSON;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GENOME; BACTERIUM MUTANT; CONTROLLED STUDY; DRUG EXPOSURE; GENE INSERTION SEQUENCE; GENE TRANSLOCATION; GENETIC RECOMBINATION; INVERTED REPEAT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; PROMOTER REGION; PULSED FIELD GEL ELECTROPHORESIS; START CODON; ACINETOBACTER INFECTIONS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHENOTYPE; PLASMID; TRANSPOSON;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; BETA-LACTAMASES; DNA TRANSPOSABLE ELEMENTS; ELECTROPHORESIS, GEL, PULSED-FIELD; GENE EXPRESSION REGULATION, BACTERIAL; GENOTYPE; HUMANS; IMIPENEM; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PHENOTYPE; PLASMIDS; RNA, RIBOSOMAL, 16S;

EID: 84907473766     PISSN: 10766294     EISSN: 19318448     Source Type: Journal    
DOI: 10.1089/mdr.2014.0004     Document Type: Article

References (23)

1. Adams, M.D., E.R. Chan, N.D. Molyneaux, and R.A. Bonomo. 2010. Genomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 54:3569-3577.
2. Bonnin, R.A., P. Nordmann, and L. Poirel. 2013. Screening and deciphering antibiotic resistance in Acinetobacter baumannii: a state of the art. Expert. Rev. Anti Infect. Ther. 11:571-583.
3. Chen, T.L., R.C. Wu, M.F. Shaio, C.P. Fung, and W.L. Cho. 2008. Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. Antimicrob. Agents Chemother. 52:2573-2580.
4. Dijkshoorn, L., A. Nemec, and H. Seifert. 2007. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat. Rev. Microbiol. 5:939-951.
5. Figueiredo, S., L. Poirel, J. Croize, C. Recule, and P. Nordmann. 2009. In vivo selection of reduced susceptibility to carbapenems in Acinetobacter baumannii related to ISAba1-mediated overexpression of the natural bla(OXA-66) oxacillinase gene. Antimicrob. Agents Chemother. 53: 2657-2659.
6. Fournier, P.E., D. Vallenet, V. Barbe, S. Audic, H. Ogata, L. Poirel, H. Richet, C. Robert, S. Mangenot, C. Abergel, et al. 2006. Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet. 2:e7.
7. Heritier, C., L. Poirel, and P. Nordmann. 2006. Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii. Clin. Microbiol. Infect. 12:123-130.
8. Hornsey, M., N. Loman, D.W. Wareham, M.J. Ellington, M.J. Pallen, J.F. Turton, A. Underwood, T. Gaulton, C.P. Thomas, M. Doumith, et al. 2011. Wholegenome comparison of two Acinetobacter baumannii isolates from a single patient, where resistance developed during tigecycline therapy. J. Antimicrob. Chemother. 66: 1499-1503.
9. Kuo, H.Y., K.C. Chang, J.W. Kuo, H.W. Yueh, and M.L. Liou. 2012. Imipenem: a potent inducer of multidrug resistance in Acinetobacter baumannii. Int J Antimicrob Agents 39:33-38.
10. Kuo, H.Y., C.M. Yang, M.F. Lin, W.L. Cheng, N. Tien, and M.L. Liou. 2010. Distribution of blaOXA-carrying imipenem-resistant Acinetobacter spp. in 3 hospitals in Taiwan. Diagn. Microbiol. Infect. Dis. 66:195-199.
11. Lin, M.F., H.Y. Kuo, H.W. Yeh, C.M. Yang, C.H. Sung, C.C. Tu, M.L. Huang, and M.L. Liou. 2011. Emergence and dissemination of bla(OXA-23)-carrying imipenemresistant Acinetobacter sp in a regional hospital in Taiwan. J. Microbiol. Immunol. Infect. 44:39-44.
12. Liu, C.C., C.Y. Tang, H.Y. Kuo, C.W. Lu, K.C. Chang, and M.L. Liou. 2013. The origin of Acinetobacter baumannii TYTH-1: a comparative genomics study. Int. J. Antimicrob. Agents 41:318-324.
13. Livak, K.J., and T.D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
14. Maragakis, L.L., and T.M. Perl. 2008. Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options. Clin. Infect. Dis. 46:1254-1263.
15. Mugnier, P.D., L. Poirel, and P. Nordmann. 2009. Functional analysis of insertion sequence ISAba1, responsible for genomic plasticity of Acinetobacter baumannii. J. Bacteriol. 191:2414-2418.
16. Mussi, M.A., A.S. Limansky, and A.M. Viale. 2005. Acquisition of resistance to carbapenems in multidrugresistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins. Antimicrob. Agents Chemother. 49:1432-1440.
17. Peleg, A.Y., H. Seifert, and D.L. Paterson. 2008. Acinetobacter baumannii: emergence of a successful pathogen. Clin. Microbiol. Rev. 21:538-582.
18. Perez, F., A.M. Hujer, K.M. Hujer, B.K. Decker, P.N. Rather, and R.A. Bonomo. 2007. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 51:3471-3484.
19. Poirel, L., and P. Nordmann. 2006. Genetic structures at the origin of acquisition and expression of the carbapenemhydrolyzing oxacillinase gene blaOXA-58 in Acinetobacter baumannii. Antimicrob. Agents Chemother. 50:1442-1448.
20. Segal, H., R.K. Jacobson, S. Garny, C.M. Bamford, and B.G. Elisha. 2007. Extended -10 promoter in ISAba-1 upstream of blaOXA-23 from Acinetobacter baumannii. Antimicrob. Agents Chemother. 51:3040-3041.
21. Snitkin, E.S., A.M. Zelazny, C.I. Montero, F. Stock, L. Mijares, P.R. Murray, and J.A. Segre. 2011. Genomewide recombination drives diversification of epidemic strains of Acinetobacter baumannii. Proc. Natl. Acad. Sci. U. S. A. 108:13758-13763.
22. Turton, J.F., M.E. Ward, N. Woodford, M.E. Kaufmann, R. Pike, D.M. Livermore, and T.L. Pitt. 2006. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol. Lett. 258:72-77.
23. Wikler, M.A., and Clinical and Laboratory Standards Institute. 2009. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard. Clinical and Laboratory Standards Institute,. 8th ed. Clinical and Laboratory Standards Institute, Wayne, PA, pp. xvi, 65 p.