메뉴 건너뛰기




Volumn 6, Issue 1, 2014, Pages 32-39

Structural characterization and mutational assessment of podocin — A novel drug target to nephrotic syndrome — An in silico approach

Author keywords

homology modeling; missense mutation; mutagenesis; NPHS2; podocin

Indexed keywords

LIGAND; MEMBRANE PROTEIN; PODOCIN; SIGNAL PEPTIDE;

EID: 84907423992     PISSN: 19132751     EISSN: 18671462     Source Type: Journal    
DOI: 10.1007/s12539-014-0190-4     Document Type: Article
Times cited : (18)

References (41)
  • 1
    • 0025183708 scopus 로고
    • Basic local alignment search tool
    • COI: 1:CAS:528:DyaK3MXitVGmsA%3D%3D, PID: 2231712
    • Altschul, S.F., Gish, W., Miller, W., Myers, E.W., Lipman, D.J. 1990. Basic local alignment search tool. J Mol Biol 215, 403–410.
    • (1990) J Mol Biol , vol.215 , pp. 403-410
    • Altschul, S.F.1    Gish, W.2    Miller, W.3    Myers, E.W.4    Lipman, D.J.5
  • 2
    • 0014018461 scopus 로고
    • Long-term assessment of steroid therapy in childhood nephrosis
    • COI: 1:STN:280:DyaF2s%2FhvV2msQ%3D%3D, PID: 4162167
    • Arneil, G.C., Lam, C.N. 1966. Long-term assessment of steroid therapy in childhood nephrosis. Lancet 2, 819–821.
    • (1966) Lancet , vol.2 , pp. 819-821
    • Arneil, G.C.1    Lam, C.N.2
  • 5
    • 37549024654 scopus 로고    scopus 로고
    • The Protein Data Bank: A historical perspective
    • PID: 18156675
    • Berman, H.M. 2007. The Protein Data Bank: A historical perspective. Acta Crystallogr A 64, 88–95.
    • (2007) Acta Crystallogr A , vol.64 , pp. 88-95
    • Berman, H.M.1
  • 7
    • 0034034757 scopus 로고    scopus 로고
    • NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome
    • COI: 1:CAS:528:DC%2BD3cXisVCjsb4%3D, PID: 10742096
    • Boute, N., Gribouval, O., Roselli, S., Benessy, F., Lee, H., Fuchshuber, A., Antignac, C. 2000. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24, 349–354.
    • (2000) Nat Genet , vol.24 , pp. 349-354
    • Boute, N.1    Gribouval, O.2    Roselli, S.3    Benessy, F.4    Lee, H.5    Fuchshuber, A.6    Antignac, C.7
  • 8
    • 0001937145 scopus 로고
    • The nephrotic syndrome: A historical review
    • Cameron JS, Glassock RJ, Whelton A, (eds), Marcel Dekker, Inc., New York
    • Cameron, J.S. 1988. The nephrotic syndrome: A historical review. In: Cameron, J.S., Glassock, R.J., Whelton, A. (Eds.) The Nephrotic Syndrome, Volume 8. Marcel Dekker, Inc., New York, 3–56.
    • (1988) The Nephrotic Syndrome , pp. 3-56
    • Cameron, J.S.1
  • 10
    • 0042622443 scopus 로고    scopus 로고
    • DSSPcont: Continuous secondary structure assignments for proteins
    • COI: 1:CAS:528:DC%2BD3sXltVWisbw%3D
    • Carter, P., Andersen, C.A.F., Rost, B. 2003. DSSPcont: Continuous secondary structure assignments for proteins. Nucl Acid Res 31, 3293–3295.
    • (2003) Nucl Acid Res , vol.31 , pp. 3293-3295
    • Carter, P.1    Andersen, C.A.F.2    Rost, B.3
  • 11
    • 0141617541 scopus 로고    scopus 로고
    • The design of Jemboss: A graphical user interface to EMBOSS
    • COI: 1:CAS:528:DC%2BD3sXot1Ckurs%3D
    • Carver, T., Bleasby, A. 2003. The design of Jemboss: A graphical user interface to EMBOSS. Oxford J Bioinformatics 19, 1837–1843.
    • (2003) Oxford J Bioinformatics , vol.19 , pp. 1837-1843
    • Carver, T.1    Bleasby, A.2
  • 12
    • 0032429154 scopus 로고    scopus 로고
    • A DNA polymorphism discovery resource for research on human genetic variation
    • COI: 1:CAS:528:DyaK1MXmtVSitg%3D%3D, PID: 9872978
    • Collins, F.S., Brooks, L.D., Chakravarti, A. 1998. A DNA polymorphism discovery resource for research on human genetic variation. Genome Res 8, 1229–1231.
    • (1998) Genome Res , vol.8 , pp. 1229-1231
    • Collins, F.S.1    Brooks, L.D.2    Chakravarti, A.3
  • 13
    • 0031790657 scopus 로고    scopus 로고
    • Computational site-directed mutagenesis of haloalkane dehalogenase in position 172
    • PID: 9862209
    • Damborský, J., Bohac, M., Prokop, M., Kutý, M., Koca, J. 1998. Computational site-directed mutagenesis of haloalkane dehalogenase in position 172. Protein Eng 11, 901–907.
    • (1998) Protein Eng , vol.11 , pp. 901-907
    • Damborský, J.1    Bohac, M.2    Prokop, M.3    Kutý, M.4    Koca, J.5
  • 15
    • 0036007347 scopus 로고    scopus 로고
    • Mutations in NPHS2 encoding podocin are a prevalent cause of steroid-resistant nephrotic syndrome among Israeli-Arab children
    • COI: 1:CAS:528:DC%2BD38XhtlWju7w%3D, PID: 11805168
    • Frishberg, Y., Rinat, C., Megged, O., Shapira, E., Feinstein, S., Raas-Rothschild, A. 2002. Mutations in NPHS2 encoding podocin are a prevalent cause of steroid-resistant nephrotic syndrome among Israeli-Arab children. J Am Soc Nephrol 13, 400–405.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 400-405
    • Frishberg, Y.1    Rinat, C.2    Megged, O.3    Shapira, E.4    Feinstein, S.5    Raas-Rothschild, A.6
  • 16
    • 0035141496 scopus 로고    scopus 로고
    • Clinical and genetic evaluation of familial steroid-responsive nephrotic syndrome in childhood
    • COI: 1:STN:280:DC%2BD3M7mt1Citw%3D%3D, PID: 11158229
    • Fuchshuber, A., Gribouval, O., Ronner, V., Kroiss, S., Karle, S., Brandis, M., Hildebrandt, F. 2001. Clinical and genetic evaluation of familial steroid-responsive nephrotic syndrome in childhood. J Am Soc Nephrol 12, 374–378.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 374-378
    • Fuchshuber, A.1    Gribouval, O.2    Ronner, V.3    Kroiss, S.4    Karle, S.5    Brandis, M.6    Hildebrandt, F.7
  • 19
    • 0028839194 scopus 로고
    • A stomatin-like protein necessary for mechanosensation in C. elegans
    • COI: 1:CAS:528:DyaK2MXpsVylsbc%3D, PID: 7477350
    • Huang, M., Gu, G., Ferguson, E.L., Chalfie, M. 1995. A stomatin-like protein necessary for mechanosensation in C. elegans. Nature 378, 292–295.
    • (1995) Nature , vol.378 , pp. 292-295
    • Huang, M.1    Gu, G.2    Ferguson, E.L.3    Chalfie, M.4
  • 20
    • 0035834659 scopus 로고    scopus 로고
    • Interaction with podocin facilitates nephrin signaling
    • COI: 1:CAS:528:DC%2BD3MXosVGns7s%3D, PID: 11562357
    • Huber, T.B., Kottgen, M., Schilling, B., Walz, G., Benzing, T. 2001. Interaction with podocin facilitates nephrin signaling. J Biol Chem 276, 41543–41546.
    • (2001) J Biol Chem , vol.276 , pp. 41543-41546
    • Huber, T.B.1    Kottgen, M.2    Schilling, B.3    Walz, G.4    Benzing, T.5
  • 21
    • 34447136072 scopus 로고    scopus 로고
    • Podocin organizes ion channel-lipid supercomplexes: Implications for mechanosensation at the slit diaphragm
    • COI: 1:CAS:528:DC%2BD2sXmsVOisrg%3D, PID: 17570936
    • Huber, T.B., Schermer, B., Benzing, T. 2007. Podocin organizes ion channel-lipid supercomplexes: Implications for mechanosensation at the slit diaphragm. Nephron Exp Nephrol 106, e27–e31.
    • (2007) Nephron Exp Nephrol , vol.106 , pp. e27-e31
    • Huber, T.B.1    Schermer, B.2    Benzing, T.3
  • 22
    • 68949208589 scopus 로고    scopus 로고
    • A search for energy minimized sequences of proteins
    • PID: 19690619
    • Jha, A.N., Ananthasuresh, G.K., Vishveshwara, S. 2009. A search for energy minimized sequences of proteins. PLoS ONE 4, e6684.
    • (2009) PLoS ONE , vol.4 , pp. e6684
    • Jha, A.N.1    Ananthasuresh, G.K.2    Vishveshwara, S.3
  • 23
    • 0036151614 scopus 로고    scopus 로고
    • Novel mutations in NPHS2 detected in both familial and sporadic steroidresistant nephrotic syndrome
    • COI: 1:CAS:528:DC%2BD38XhtlWju74%3D, PID: 11805166
    • Karle, S.M., Uetz, B., Ronner, V., Glaeser, L., Hildebrandt, F., Fuchshuber, A. 2002. Novel mutations in NPHS2 detected in both familial and sporadic steroidresistant nephrotic syndrome. J Am Soc Nephrol 13, 388–393.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 388-393
    • Karle, S.M.1    Uetz, B.2    Ronner, V.3    Glaeser, L.4    Hildebrandt, F.5    Fuchshuber, A.6
  • 24
    • 84892386538 scopus 로고    scopus 로고
    • Computational evaluation of new homologous down regulators of Translationally Controlled Tumor Protein (TCTP) targeted for tumor reversion
    • COI: 1:CAS:528:DC%2BC2cXptVCltw%3D%3D
    • Nayarisseri, A., Yadav, M., Wishard, R. 2013. Computational evaluation of new homologous down regulators of Translationally Controlled Tumor Protein (TCTP) targeted for tumor reversion. Interdiscip Sci Comput Life Sci 5, 274–279.
    • (2013) Interdiscip Sci Comput Life Sci , vol.5 , pp. 274-279
    • Nayarisseri, A.1    Yadav, M.2    Wishard, R.3
  • 25
    • 33750353461 scopus 로고    scopus 로고
    • Predicting the effects of amino acid substitutions on protein function
    • COI: 1:CAS:528:DC%2BD28Xht1WgsrzJ, PID: 16824020
    • Ng, P.C., Henikoff, S. 2006. Predicting the effects of amino acid substitutions on protein function. Annu Rev Genomics Hum Genet 7, 61–80.
    • (2006) Annu Rev Genomics Hum Genet , vol.7 , pp. 61-80
    • Ng, P.C.1    Henikoff, S.2
  • 26
    • 0036293340 scopus 로고    scopus 로고
    • Interaction of endogenous nephrin and CD2-associated protein in mouse epithelial M-1 cell line
    • COI: 1:CAS:528:DC%2BD38XlvVSqtrw%3D, PID: 12089372
    • Palmen, T., Lehtonen, S., Ora, A., Kerjaschki, D., Antignac, C., Lehtonen, E., Holthofer, H. 2002. Interaction of endogenous nephrin and CD2-associated protein in mouse epithelial M-1 cell line. J Am Soc Nephrol 13, 1766–1772.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1766-1772
    • Palmen, T.1    Lehtonen, S.2    Ora, A.3    Kerjaschki, D.4    Antignac, C.5    Lehtonen, E.6    Holthofer, H.7
  • 27
    • 0037207471 scopus 로고    scopus 로고
    • Cell biology of the glomerular podocyte
    • COI: 1:CAS:528:DC%2BD3sXntlGgtw%3D%3D, PID: 12506131
    • Pavenstadt, H., Kriz, W., Kretzler, M. 2003. Cell biology of the glomerular podocyte. Physiol Rev 83, 253–307.
    • (2003) Physiol Rev , vol.83 , pp. 253-307
    • Pavenstadt, H.1    Kriz, W.2    Kretzler, M.3
  • 28
    • 50549100935 scopus 로고    scopus 로고
    • TRITON: A graphical tool for ligandbinding protein engineering
    • COI: 1:CAS:528:DC%2BD1cXhtVGlurrN, PID: 18603567
    • Prokop, M., Adam, J., Køž, Z., Wimmerová, M., Koèa, J. 2008. TRITON: A graphical tool for ligandbinding protein engineering. Bioinformatics 24, 1955–1956.
    • (2008) Bioinformatics , vol.24 , pp. 1955-1956
    • Prokop, M.1    Adam, J.2    Køž, Z.3    Wimmerová, M.4    Koèa, J.5
  • 29
    • 0033671178 scopus 로고    scopus 로고
    • TRITON: In silico construction of protein mutants and prediction of their activities
    • COI: 1:CAS:528:DC%2BD3MXovFai, PID: 11187152
    • Prokop, M., Damborský, J., Kocă, J. 2000. TRITON: In silico construction of protein mutants and prediction of their activities. Bioinformatics 16, 845–846.
    • (2000) Bioinformatics , vol.16 , pp. 845-846
    • Prokop, M.1    Damborský, J.2    Kocă, J.3
  • 30
    • 73649194755 scopus 로고
    • Stereochemistry of polypeptide chain configurations
    • COI: 1:CAS:528:DyaF3sXks1arsLk%3D, PID: 13990617
    • Ramachandran, G.N., Ramakrishnan, C., Sasisekharan, V. 1963. Stereochemistry of polypeptide chain configurations. J Mol Biol 7, 95–99.
    • (1963) J Mol Biol , vol.7 , pp. 95-99
    • Ramachandran, G.N.1    Ramakrishnan, C.2    Sasisekharan, V.3
  • 31
    • 84869120020 scopus 로고    scopus 로고
    • Comparative modeling of methylentetrahydrofolate reductase (MTHFR) enzyme and its mutational assessment: In silico approach
    • Rao, D.M, Anuraj, N. Yadav, M. Showmy, K.S., Patel, D. 2010. Comparative modeling of methylentetrahydrofolate reductase (MTHFR) enzyme and its mutational assessment: In silico approach. IJBR 2, 5–9.
    • (2010) IJBR , vol.2 , pp. 5-9
    • Rao, D.M.1    Anuraj, N.2    Yadav, M.3    Showmy, K.S.4    Patel, D.5
  • 33
    • 0027136282 scopus 로고
    • Comparative protein modeling by satisfaction of spatial restraints
    • COI: 1:CAS:528:DyaK2cXnt1ylug%3D%3D, PID: 8254673
    • Sali, A., Blundell, T.L. 1993. Comparative protein modeling by satisfaction of spatial restraints. J Mol Biol 234, 779–815.
    • (1993) J Mol Biol , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 34
    • 0035210324 scopus 로고    scopus 로고
    • Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD 2AP and nephrin
    • COI: 1:CAS:528:DC%2BD3MXovVCgs7g%3D, PID: 11733557
    • Schwarz, K., Simons, M., Reiser, J., Saleem, M.A., Faul, C., Kriz, W., Shaw, A.S., Holzman, L.B., Mundel, P. 2001. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD 2AP and nephrin. J Clin Invest 108, 1621–1629.
    • (2001) J Clin Invest , vol.108 , pp. 1621-1629
    • Schwarz, K.1    Simons, M.2    Reiser, J.3    Saleem, M.A.4    Faul, C.5    Kriz, W.6    Shaw, A.S.7    Holzman, L.B.8    Mundel, P.9
  • 36
    • 0034858027 scopus 로고    scopus 로고
    • Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm
    • COI: 1:CAS:528:DC%2BD3MXnt12mtr0%3D, PID: 11549599
    • Simons, M., Schwarz, K., Kriz, W., Miettinen, A., Reiser, J., Mundel, P., Holthöfer, H. 2001. Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm. Am J Pathol 159, 1069–1077.
    • (2001) Am J Pathol , vol.159 , pp. 1069-1077
    • Simons, M.1    Schwarz, K.2    Kriz, W.3    Miettinen, A.4    Reiser, J.5    Mundel, P.6    Holthöfer, H.7
  • 37
    • 0025390935 scopus 로고
    • MOPAC — A semiempirical molecular-orbital program
    • Stewart, J.J.P. 1990. MOPAC — A semiempirical molecular-orbital program. J Comput Aid Molec Design 4, 1–45.
    • (1990) J Comput Aid Molec Design , vol.4 , pp. 1-45
    • Stewart, J.J.P.1
  • 38
    • 0031669184 scopus 로고    scopus 로고
    • Overlapping genomic sequences: A treasure trove of single-nucleotide polymorphisms
    • COI: 1:CAS:528:DyaK1cXltFeltr0%3D, PID: 9685323
    • Taillon-Miller, P., Gu, Z., Li, Q., Hillier, L., Kwok, P.Y. 1998. Overlapping genomic sequences: A treasure trove of single-nucleotide polymorphisms. Genome Res 8, 748–754.
    • (1998) Genome Res , vol.8 , pp. 748-754
    • Taillon-Miller, P.1    Gu, Z.2    Li, Q.3    Hillier, L.4    Kwok, P.Y.5
  • 39
    • 0035227054 scopus 로고    scopus 로고
    • A novel polymorphism (c288C T) of the NPHS2 gene identified in a Taiwan Chinese family
    • COI: 1:CAS:528:DC%2BD3MXoslGisLo%3D, PID: 11139267
    • Wu, M.C., Wu, J.Y., Lee, C.C., Tsai, C.H., Tsai, F.J. 2001a. A novel polymorphism (c288C T) of the NPHS2 gene identified in a Taiwan Chinese family. Hum Mutat 17, 81–82.
    • (2001) Hum Mutat , vol.17 , pp. 81-82
    • Wu, M.C.1    Wu, J.Y.2    Lee, C.C.3    Tsai, C.H.4    Tsai, F.J.5
  • 40
    • 0035292682 scopus 로고    scopus 로고
    • Two novel polymorphisms (c954T C and c1038A G) in exon8 of NPHS2 gene identified in Taiwan Chinese
    • COI: 1:STN:280:DC%2BD3M3msFGiuw%3D%3D, PID: 11241850
    • Wu, M.C., Wu, J.Y., Lee, C.C., Tsai, C.H., Tsai, F.J. 2001b. Two novel polymorphisms (c954T C and c1038A G) in exon8 of NPHS2 gene identified in Taiwan Chinese. Hum Mutat 17, 237.
    • (2001) Hum Mutat , vol.17 , pp. 237
    • Wu, M.C.1    Wu, J.Y.2    Lee, C.C.3    Tsai, C.H.4    Tsai, F.J.5
  • 41
    • 84909986360 scopus 로고    scopus 로고
    • Comparative modeling of 3-oxoacyl-acyl-carrier protein synthase I/II in plasmodium falciparum — A potent target of malaria
    • Yadav, M., Anuraj, N., Rajput, S.G., Jain, A., Verma, A., Gupta, P. 2009. Comparative modeling of 3-oxoacyl-acyl-carrier protein synthase I/II in plasmodium falciparum — A potent target of malaria. IJBR 1, 100–103.
    • (2009) IJBR , vol.1 , pp. 100-103
    • Yadav, M.1    Anuraj, N.2    Rajput, S.G.3    Jain, A.4    Verma, A.5    Gupta, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.