A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft

Science Translational Medicine

Volumn 6, Issue 249, 2014, Pages

  Gajanayake, Thusitha ^a,b   Olariu, Radu ^a,b   Leclère, Franck M ^a,b   Dhayani, Ashish ^c   Yang, Zijiang ^d   Bongoni, Anjan K ^b   Banz, Yara ^e   Constantinescu, Mihai A ^a,b   Karp, Jeffrey M ^d   Vemula, Praveen Kumar ^c   Rieben, Robert ^b   Vögelin, Esther ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENT COMPONENT C3; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 2; LIPID; TACROLIMUS; TRIGLYCEROL MONOSTEARATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; COMPLEMENT; CYTOKINE; ENZYME; HYDROGEL; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPOSITE GRAFT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG RELEASE; DRUG TISSUE LEVEL; ENCAPSULATION; GELATION; GRAFT REJECTION; GRAFT SURVIVAL; HISTOPATHOLOGY; HUMORAL IMMUNITY; HYDROGEL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; KIDNEY INJURY; LIVER INJURY; LONG TERM SURVIVAL; MALE; NONHUMAN; RAT; SURVIVAL TIME; VASCULARIZED COMPOSITE ALLOGRAFT; ANIMAL; ANTIBODY SPECIFICITY; BLOOD; CELL LINE; CHEMISTRY; COMPLEMENT ACTIVATION; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; KIDNEY; LIVER; METABOLISM; MOUSE; PATHOLOGY; PHARMACOLOGY; SKIN; TIME;

ANIMALS; ANTIBODY SPECIFICITY; BIOLOGICAL MARKERS; CELL LINE; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM PROTEINS; COMPOSITE TISSUE ALLOGRAFTS; CYTOKINES; ENZYMES; GRAFT SURVIVAL; HYDROGEL; IMMUNITY, HUMORAL; INFLAMMATION; KIDNEY; LIVER; MALE; MICE; RATS; SKIN; TACROLIMUS; TIME FACTORS; TRIGLYCERIDES;

EID: 84907404433     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3008778     Document Type: Article

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