Effectiveness of topical immunosuppressants in prevention and treatment of rejection in face allotransplantation

Transplantation

Volumn 95, Issue 10, 2013, Pages 1197-1203

  Gharb, Bahar Bassiri ^a   Rampazzo, Antonio ^a   Altuntas, Selman Hakki ^a   Madajka, Maria ^a   Cwykiel, Joanna ^a   Stratton, Jason ^a   Siemionow, Maria Zofia ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Clobetasol; Face allotransplantation; Tacrolimus; Topical immunosuppressants; Vascularized composite allotransplantation

Indexed keywords

ALPHA BETA T LYMPHOCYTE RECEPTOR ANTIBODY; CD45RA ANTIGEN; CLOBETASOL; CYCLOSPORIN A; GAMMA INTERFERON; INTERLEUKIN 2; RECEPTOR ANTIBODY; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; CONTROLLED STUDY; CORNEA ULCER; DRUG EFFICACY; GRAFT REJECTION; GRAFT SURVIVAL; HEMIFACE ALLOTRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE DEPLETION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKINFOLD THICKNESS; WOUND DEHISCENCE;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIGENS, CD3; ANTIGENS, CD45; CYTOKINES; FACIAL TRANSPLANTATION; GRAFT REJECTION; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTES; RATS; RATS, INBRED ACI; RATS, INBRED LEW; SKIN; TRANSPLANTATION, HOMOLOGOUS;

EID: 84878585174     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31828bca61     Document Type: Article

References (14)

1. Dubernard JM, Owen E, Lefrancois N, et al. First human hand transplantation. Case report. Transpl Int 2000; 13(Suppl 1): S521.
2. Dubernard JM, Owen E, Herzberg G, et al. Human hand allograft: report on first 6 months. Lancet 1999; 353: 1315.
3. Petruzzo P, Lanzetta M, Dubernard JM, et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation 2010; 90: 1590.
4. Kanitakis J. The challenge of dermatopathological diagnosis of composite tissue allograft rejection: a review. J Cutan Pathol 2008; 35: 738.
5. Cendales LC, Kirk AD, Moresi JM, et al. Composite tissue allotransplantation: classification of clinical acute skin rejection. Transplantation 2005; 80: 1676.
6. Einecke G, Mengel M, Hidalgo L, et al. The early course of kidney allograft rejection: defining the time when rejection begins. Am J Transplant 2009; 9: 483.
7. Kwun J, Knechtle SJ, Hu H. Determination of the functional status of alloreactive T cells by interferon-gamma kinetics. Transplantation 2006; 81: 590.
8. Baan CC, Knoop CJ, van Gelder T, et al. Anti-CD25 therapy reveals the redundancy of the intragraft cytokine network after clinical heart transplantation. Transplantation 1999; 67: 870.
9. BaanCC,NiestersHG,Metselaar HJ, et al. Increased intragraft IL-15mRNA expression after liver transplantation. Clin Transplant 1998; 12: 212.
10. Pavlakis M, Strehlau J, Lipman M, et al. Intragraft IL-15 transcripts are increased in human renal allograft rejection. Transplantation 1996; 62: 543.
11. Wang WL, Yao MY, Jin J, et al. Increased expression of noninterleukin- 2 T cell growth factors and their implications during liver allograft rejection in rats. J Gastroenterol Hepatol 2007; 22: 1141.
12. Kaufman CL, Ouseph R, Blair B, et al. Graft vasculopathy in clinical hand transplantation. Am J Transplant 2012; 12: 1004.
13. Cendales LC, Kanitakis J, Schneeberger S, et al. The Banff 2007 working classification of skin-containing composite tissue allograft pathology. Am J Transplant 2008; 8: 1396.
14. Demir Y, Ozmen S, Klimczak A, et al. Tolerance induction in composite facial allograft transplantation in the rat model. Plast Reconstr Surg 2004; 114: 1790.