Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits

Colloids and Surfaces B: Biointerfaces

Volumn 122, Issue , 2014, Pages 423-431

  Warsi, Musarrat H ^a   Anwar, Mohammed ^a   Garg, Vaidehi ^a   Jain, Gaurav K ^a   Talegaonkar, Sushama ^a   Ahmad, Farhan J ^a   Khar, Roop K ^a,b  

^a HAMDARD UNIVERSITY   (India)

^b B S Anangpuria Institute of Pharmacy   (India)

Author keywords

Dorzolamide; Intraocular pressure; Ocular pharmacoscintigraphy; PLGA; Vitamin E TPGS

Indexed keywords

BIOCHEMISTRY; COPOLYMERS; EMULSIFICATION; NANOPARTICLES; OPHTHALMOLOGY;

DORZOLAMIDE; INTRA OCULAR PRESSURE; OCULAR PHARMACOSCINTIGRAPHY; PLGA; VITAMIN E TPGS;

ENCAPSULATION;

DORZOLAMIDE; DORZOLAMIDE LOADED POLYGLACTIN NANOPARTICLE; EMULSIFYING AGENT; NANOPARTICLE; POLYGLACTIN; POLYVINYL ALCOHOL; UNCLASSIFIED DRUG; VITAMIN E TOCOFERSOLAN; ALPHA TOCOPHEROL; ALPHA-TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE; CARBONATE DEHYDRATASE INHIBITOR; LACTIC ACID; MACROGOL DERIVATIVE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; RETINOL; SULFONAMIDE; THIOPHENE DERIVATIVE; TOCOFERSOLAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CONTROLLED STUDY; CORNEA; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG INSTILLATION; DRUG PENETRATION; DRUG SOLUTION; ENCAPSULATION; EX VIVO STUDY; GAMMA CAMERA; GAMMA SCINTIGRAPHY; GLAUCOMA; HISTOLOGY; INTRAOCULAR PRESSURE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG EFFECTS; OCULAR HYPERTENSION; SCANNING ELECTRON MICROSCOPY; SCINTISCANNING; ADULT; ANTIHYPERTENSIVE ACTIVITY; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG SAFETY; DRUG SOLUBILITY; DRUG UPTAKE; IN VIVO STUDY; LACRIMAL DUCT; NANOENCAPSULATION; SUSTAINED DRUG RELEASE;

ANIMALS; CARBONIC ANHYDRASE INHIBITORS; GLAUCOMA; INTRAOCULAR PRESSURE; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; OCULAR HYPERTENSION; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; RABBITS; SULFONAMIDES; THIOPHENES; VITAMIN A; VITAMIN E;

EID: 84907329099     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2014.07.004     Document Type: Article

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